The CENTER-TBI Core dataset is a large dataset containing over 2,500 variables.
The main structure of the e-CRF consists of data related to:

  1. The patient type, injury, and enrollment
  2. The pre-hospital and presentation status
  3. Additional Ward or ICU data (depending on the type of patient)
  4. Additional MRI or HR ICU data (depending on the sub-studies performed)
  5. Transitions of care
  6. Treatment (labs, medication, surgery)
  7. Outcome assessments

Click to access the detailed structure. Within the structure, you can access the corresponding e-CRF forms.

Frequency Tables

We have been developing Frequency Tables for the CENTER-TBI data. These Frequency Tables do not lend themselves to analyses of the CENTER-TBI data, but serve to provide some orientating insight into the availability and distribution of data in the CENTER-TBI dataset. The Frequency Tables are available here.

For further insight into the CENTER-TBI dataset we also refer to the descriptive core paper of our Consortium:

Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study

Ewout W Steyerberg, Eveline Wiegers, Charlie Sewalt, Andras Buki, Giuseppe Citerio, Véronique De Keyser et al.

Lancet Neurol. 2019 Oct; 18 (10): 923-934. Doi: 10.1016/S1474-4422(19)30232-7

CENTER-TBI Variables

The complete list of CENTER-TBI variables available with their corresponding description is available below:

Variable Label Lookup values Description
AIS.InjAIS AIS 5 == 5
6 == 6
3 == 3
4 == 4
2 == 2
1 == 1
0 == 0
In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries. This is the AIS score for body regions as specified by AIS.InjBodyRegion.
AIS.InjBodyRegion Body region 1 == Externa
12 == Pelvic Girdle
11 == Lower Extremities
10 == Upper Extremities
9 == Lumbar Spine
8 == Abdomen/Pelvic Contents
7 == Thoracic Spine
6 == Thorax/Chest
5 == Face
3 == Brain Injury
4 == Cervical Spine
2 == Head and Neck-Other
Injuries and their severity are recorded according to a (modification of) the AIS. The AIS recognizes 6 main body regions. We included a further subdivision for some body regions, resulting in a total of 12 regions. For example, spine is not considered separately in the original AIS classification, but included under neck/chest and abdomen regions. For TBI, however, we considered it important to record spine separately.
AIS.InjDescription Description of injury 55 == Pelvic Girdle: Other
54 == Lower Extremities: Other
53 == Upper Extremities: Other
52 == Thoracic Spine: Other
51 == Externa: Other
50 == Pelvic Girdle: Hip dislocation
49 == Pelvic Girdle: Hip fracture
48 == Pelvic Girdle: Pelvic fracture
47 == Lower Extremities: Fibula fracture
46 == Lower Extremities: Metatarsal/tarsal fracture (toe fracture)
45 == Lower Extremities: Calcaneus fracture
44 == Lower Extremities: Ankle fracture
43 == Lower Extremities: Tibia fracture
42 == Lower Extremities: Tibia plateau fracture
41 == Lower Extremities: Femoral fracture
40 == Upper Extremities: Finger
39 == Upper Extremities: Hand
38 == Upper Extremities: Dislocation
37 == Upper Extremities: Radial and/or ulnar fracture
36 == Upper Extremities: Humerus fracture
35 == Lumbar Spine: Other
34 == Lumbar Spine: Sacral fracture
33 == Lumbar Spine: Dislocation
32 == Lumbar Spine: Fracture
31 == Abdomen/Pelvic Contents: Other
29 == Abdomen/Pelvic Contents: Kidney contusion
30 == Abdomen/Pelvic Contents: Retroperitoneal hematoma
28 == Abdomen/Pelvic Contents: Perforating abdominal injury
27 == Abdomen/Pelvic Contents: Liver rupture
26 == Abdomen/Pelvic Contents: Spleen rupture
25 == Thoracic Spine: Dislocation
24 == Thoracic Spine: Fracture
23 == Thorax/Chest: Other
22 == Thorax/Chest: Hemato-thorax
21 == Thorax/Chest: Pneumo-thorax
20 == Thorax/Chest: Aorta dissection
19 == Thorax/Chest: Cardiac contusion
18 == Thorax/Chest: Lung contusion
17 == Thorax/Chest: Rib fracture
16 == Face: Other
15 == Face: Zygomatic arch fracture
14 == Face: Orbital fracture
13 == Face: Maxillo-facial fracture le Fort III
12 == Face: Maxillo-facial fracture le Fort II
11 == Face: Maxillo-facial fracture le Fort I
10 == Cervical Spine: Other
9 == Cervical Spine: Dislocation
8 == Cervical Spine: Fracture
6 == Brain Injury: Other
5 == Brain Injury: ASDH
4 == Brain Injury: Diffuse Injury
2 == Brain Injury: Contusions
3 == Brain Injury: EDH
7 == Head and Neck-Other: Specify in comments box
1 == Brain Injury: Concussion
List of body regions with 55 subcategories describing the injury.
AIS.InjDesOther Other description of injury (please specify) Free text specifying the injury when AIS.InjDescription is "other"
Biomarkers.AliquotID1 Biomarker Aliquot 1 Biomarker Aliquot 1: Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials.
Biomarkers.AliquotID2 Biomarker Aliquot 2 Biomarker Aliquot 2: Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials.
Biomarkers.AliquotID3 Biomarker Aliquot 3 Biomarker Aliquot 3: Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials.
Biomarkers.AliquotID4 Biomarker Aliquot 4 Biomarker Aliquot 4: Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials.
Biomarkers.AliquotID5 Biomarker Aliquot 5 Biomarker Aliquot 5: Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials.
Biomarkers.AliquotID6 Biomarker Aliquot 6 Biomarker Aliquot 6: Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials.
Biomarkers.AliquotID7 Biomarker Aliquot 7 Biomarker Aliquot 7: Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials.
Biomarkers.AliquotID8 Biomarker Aliquot 8 Biomarker Aliquot 8: Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials.
Biomarkers.CentrifugationDate Centrifugation date of the Biomarker sample Centrifugation Date of the Biomarker sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Biomarkers.CentrifugationTime Centrifugation time of the Biomarker sample Centrifugation Time of the Biomarker sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Biomarkers.CollectionDate Collection date of the Biomarker sample Collection Date of the Biomarker sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Biomarkers.CollectionTime Collection time of the Biomarker sample Collection Time of the Biomarker sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Biomarkers.FreezerMinusEightyDate Date the Biomarker sample was stored in a -80 freezer All processed samples should be stored at -80°C with a needle to freezer time preferably within 2 hours. This variable reflects the date and time that the biomarker sample was stored in a minus 80 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Biomarkers.FreezerMinusEightyTime Time the Biomarker sample was stored in a -80 freezer All processed samples should be stored at -80°C with a needle to freezer time preferably within 2 hours. This variable reflects the date and time that the biomarker sample was stored in a minus 80 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Biomarkers.FreezerMinusTwentyDate Date the Biomarker sample was stored in a -20 freezer All processed samples should be stored at -80°C with a needle to freezer time preferably within 2 hours. However, if a -80°C freezer was not immediately accessible, samples could be temporarily (max 48 hours) stored in a minus 20°C non-frost-free freezer. This variable reflects the date and time that the biomarker sample was stored in a minus 20 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Biomarkers.FreezerMinusTwentyTime Time the Biomarker sample was stored in a -20 freezer All processed samples should be stored at -80°C with a needle to freezer time preferably within 2 hours. However, if a -80°C freezer was not immediately accessible, samples could be temporarily (max 48 hours) stored in a minus 20°C non-frost-free freezer. This variable reflects the date and time that the biomarker sample was stored in a minus 20 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Biomarkers.GFAP Glial fibrillary acidic protein [GFAP] Assay results for Glial fibrillary acidic protein [GFAP] - measured with an ultrasensitive immunoassay using digital array technology (Single Molecule Arrays, SiMoA)-based Human Neurology 4-Plex B assay (N4PB) run on the SR-X benchtop assay platform (Quanterix Corp., Lexington, MA) at the University of Florida (Gainesville, Florida).
Biomarkers.NFL Neurofilament protein-light (NFL) Assay results for Neurofilament protein-light (NFL) - measured with an ultrasensitive immunoassay using digital array technology (Single Molecule Arrays, SiMoA)-based Human Neurology 4-Plex B assay (N4PB) run on the SR-X benchtop assay platform (Quanterix Corp., Lexington, MA) at the University of Florida (Gainesville, Florida).
Biomarkers.NSE Neuron-specific enolase (NSE) Assay results for Neuron-specific enolase (NSE) - measured with a clinical-use automated system, using an electrochemiluminescence immunoassay kit (ECLIA) (Elecsys S100 and Elecsys NSE assays) run on the e 602 module of Cobas 8000 modular analyzer (Roche Diagnostics, Mannheim, Germany) at the University of Pecs (Pecs, Hungary).
Biomarkers.S100B S100 calcium binding protein B (S100B) Assay results for S100 calciumbinding protein B (S100B) - measured with a clinical-use automated system, using an electrochemiluminescence immunoassay kit (ECLIA) (Elecsys S100 and Elecsys NSE assays) run on the e 602 module of Cobas 8000 modular analyzer (Roche Diagnostics, Mannheim, Germany) at the University of Pecs (Pecs, Hungary).
Biomarkers.SampleId Sample identifier for the Biomarker sample Per patient 1x 9ml blood sample was collected in a serum separator tube. After 45 minutes (+/- 15) of coagulation at room temperature, it was centrifuged at 1500g for 10 minutes. 8x0,5ml of serum was then aliquoted into barcoded 1,8ml cryovials (see also Biomarkers.AliquotID)
Biomarkers.Tau T-TAU Assay results for T-TAU - measured with an ultrasensitive immunoassay using digital array technology (Single Molecule Arrays, SiMoA)-based Human Neurology 4-Plex B assay (N4PB) run on the SR-X benchtop assay platform (Quanterix Corp., Lexington, MA) at the University of Florida (Gainesville, Florida).
Biomarkers.UCH-L1 Ubiquitin C-terminal hydrolase ubiquitin C-terminal hydrolase L1 (UCH-L1) Assay results for Ubiquitin C-terminal hydrolase ubiquitin C-terminal hydrolase L1 (UCH-L1) - measured with an ultrasensitive immunoassay using digital array technology (Single Molecule Arrays, SiMoA)-based Human Neurology 4-Plex B assay (N4PB) run on the SR-X benchtop assay platform (Quanterix Corp., Lexington, MA) at the University of Florida (Gainesville, Florida).
Brainmonitoring.DataAvailable Data available (parameters monitored) Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites.
Brainmonitoring.DataCollectionSoftware Software used to collect HR data Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites.
Brainmonitoring.DataEndTime Data processing end time Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites. Contains the time when the high resolution processing ended. This time has been adjusted to the midnight preceding the injury .
Brainmonitoring.DataProcessingSoftware Software used to process data Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites.
Brainmonitoring.DataStartTime Data processing start time Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites. Contains the time when the high resolution processing started. This time has been adjusted to the midnight preceding the injury .
Brainmonitoring.DateTimeFormat Time format for data processing Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites.
Brainmonitoring.Duration Duration of data processing Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites.
Brainmonitoring.FormatVersion Version of data format Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites.
Brainmonitoring.HDF5URL Data URL URL to download high resolution ICU file
Brainmonitoring.InvalidValue Code for invalid value Meta data from the High Resolution ICU data collected in a subcategory of patients in specific HR-ICU sites.
CentralHaemostasis.AnnexinV_single_CD105_Annex_measurement Measurement of CD105- and AnnexinV-positive microparticles Measurement of CD105- and AnnexinV-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (single positive Annexin V+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.AnnexinV_single_CD42b_Annex_measurement Measurement of CD42b- and AnnexinV-positive microparticles Measurement of CD42b- and AnnexinV-positive microparticles for quantification of platelet-derived microparticles (PDMP) - results for platelet-derived microparticles (PDMP) (single positive Annexin V+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine PDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD105_AnnexinV_double_CD105_Annex_measurement Measurement of CD105- and AnnexinV-positive (double) microparticles Measurement of CD105- and AnnexinV-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (double positive CD105+/Annexin V+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD105_CD142_double_CD105_CD142_measurement Measurement of CD105- and CD142-positive (double) microparticles Measurement of CD105- and CD142-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (double positive CD105+/CD142+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD105_CD62E_double_CD105_CD62E_measurement Measurement of CD105- and CD62e-positive (double) microparticles Measurement of CD105- and CD62e-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (double positive CD105+/CD62e+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke..
CentralHaemostasis.CD105_single_CD105_Annex_measurement Measurement of CD105- and AnnexinV-positive microparticles Measurement of CD105- and AnnexinV-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (single positive CD105+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD105_single_CD105_CD142_measurement Measurement of CD105- and CD142-positive microparticles Measurement of CD105- and CD142-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (single positive CD105+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD105_single_CD105_CD62E_measurement Measurement of CD105- and CD62e-positive microparticles Measurement of CD105- and CD62e-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (single positive CD105+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD142_single_CD105_CD142_measurement Measurement of CD105- and CD142-positive microparticles Measurement of CD105- and CD142-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (single positive CD142+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD42b_AnnexinV_double_CD42b_Annex_measurement Measurement of CD42b- and AnnexinV-positive (double) microparticles Measurement of CD42b- and AnnexinV-positive microparticles for quantification of platelet-derived microparticles (PDMP) - results for platelet-derived micro-particles (double positive for CD42b+/Annexin V+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine PDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD42b_CD62p_double_CD42b_CD62p_measurement Measurement of CD42b- and CD62p-positive (double) microparticles Measurement of CD42b- and CD62p-positive microparticles for quantification of platelet-derived microparticles (PDMP) - results for platelet-derived microparticles (PDMP) (double positive CD42b+/CD62p+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine PDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD42b_single_CD42b_AnnexV_measurement Measurement of CD42b and AnnexinV positive microparticles Measurement of CD42b and AnnexinV positive microparticles for quantification of platelet-derived microparticles (PDMP) - results for platelet-derived microparticles (PDMP) (single positive CD42b+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine PDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD42b_single_CD42b_CD62p_measurement Measurement of CD42b- and CD62p-positive microparticles Measurement of CD42b- and CD62p-positive microparticles for quantification of platelet-derived microparticles (PDMP) - results for platelet-derived microparticles (PDMP) (single positive CD42b+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine PDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD62E_single_CD105_CD62E_measurement Measurement of CD105- and CD62e-positive microparticles Measurement of CD105- and CD62e-positive microparticles for quantification of endothelial derived microparticles (EDMP) - results for endothelial derived microparticles (EDMP) (single positive CD62e+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine EDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CD62p_single_CD42b_CD62p_measurement Measurement of CD42b- and CD62p-positive microparticles Measurement of CD42b- and CD62p-positive microparticles for quantification of platelet-derived microparticles (PDMP) - results for platelet-derived microparticles (PDMP) (single positive CD62p+) - using flow cytometry techniques. Citrated plasma sample was centrifuged for 20 min at 2,500 x g at RT. Supernatants were used to determine PDMP. Run on the BD Accuri C6 Plus flow cytometer (BD Biosciences; Heidelberg, Germany) at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.CentrifugationDate Centrifugation date of the Central Haemostasis sample Centrifugation Date and Time of the central haemostatis sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
CentralHaemostasis.CentrifugationTime Centrifugation time of the Central Haemostasis sample Centrifugation Date and Time of the central haemostatis sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
CentralHaemostasis.CitrateAliquotID1 Central Haemostasis citrate aliquot 1 Central Haemostasis citrate aliquot 1: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml and 1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.SampleID)
CentralHaemostasis.CitrateAliquotID2 Central Haemostasis citrate aliquot 2 Central Haemostasis citrate aliquot 2: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml and 1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.SampleID)
CentralHaemostasis.CitrateAliquotID3 Central Haemostasis citrate aliquot 3 Central Haemostasis citrate aliquot 3: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml and 1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.SampleID)
CentralHaemostasis.CitrateAliquotID4 Central Haemostasis citrate aliquot 4 Central Haemostasis citrate aliquot 4: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml and 1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.SampleID)
CentralHaemostasis.CitrateAliquotID5 Central Haemostasis citrate aliquot 5 Central Haemostasis citrate aliquot 5: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml and 1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.SampleID)
CentralHaemostasis.CitrateAliquotID6 Central Haemostasis citrate aliquot 6 Central Haemostasis citrate aliquot 6: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml and 1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.SampleID)
CentralHaemostasis.CitrateAliquotID7 Central Haemostasis citrate aliquot 7 Central Haemostasis citrate aliquot 7: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml and 1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.SampleID)
CentralHaemostasis.CoagulationparameterFibrinogen_mg_dl Assay results for standard coagulation test (Fibrinogen) Assay results for standard coagulation test (Fibrinogen) - using a high sensitivity thromboplastin reagent (RecombiPasTin 2G (HemosIL®), Werfen, Bedford, USA) based on recombinant human tissue factor (RTF) for quantitative determination in citrated plasma of Prothrombin time (PT) and Fibrinogen. Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 276-471 Reference: HemosIL® package insert
CentralHaemostasis.CoagulationparameterINR Assay results for standard coagulation test (INR) Assay results for standard coagulation test (INR) - using a high sensitivity thromboplastin reagent (RecombiPasTin 2G (HemosIL®), Werfen, Bedford, USA) based on recombinant human tissue factor (RTF) for quantitative determination in citrated plasma of Prothrombin time (PT) and Fibrinogen. Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre.
CentralHaemostasis.CoagulationparameterPTT_sec Assay results for standard coagulation test (PTT) Assay results for standard coagulation test (PTT) - using the HemosIL® APTT-SP kit (Werfen, Bedford, USA). Run on the ACL TOP CTS 700 (Werfen; Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 23-36 Reference: HemosIL® package insert
CentralHaemostasis.CoagulationparameterQuick_procent Assay results for standard coagulation test (Quick) Assay results for standard coagulation test (Quick) - using a high sensitivity thromboplastin reagent (RecombiPasTin 2G (HemosIL®), Werfen, Bedford, USA) based on recombinant human tissue factor (RTF) for quantitative determination in citrated plasma of Prothrombin time (PT) and Fibrinogen. Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 70-130 Reference: HemosIL® package insert
CentralHaemostasis.CoagulationparameterThrombintime_sec Assay results for standard coagulation test (Thrombin Time) Assay results for standard coagulation test (Thrombin Time) - using the HemosIL® Thrombin Time kit (Werfen, Bedford, USA). Fibrinogen in the citrated plasma sample is converted to fibrin by the addition of purified bovine thrombin and the time required to form the clot is measured. Run on the ACL TOP CTS 700 (Werfen; Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 10-17 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_Antithrombin_procent Assay results for standard coagulation test (Antithrombin) Assay results for standard coagulation test (Antithrombin) - Antithrombin in human citrated plasma measured with an automated chromogenic assay technology using the HemosIL® aliquid Antithrombin kit (Werfen, Bedford, USA). Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 83-128 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_Ddimers_ug_l Assay results for standard coagulation test (D-Dimers) Assay results for standard coagulation test (D-Dimers) - using the HemosIL® D-Dimer Controls kit (Werfen, Bedford, USA). Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 0-232 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_FactorIX_procent Assay results for standard coagulation test (Factor IX) Assay results for standard coagulation test (Factor IX) - human plasma immunodepleted of factor IX for the quantitaive determination of factor IX activity based on activated partial thromboplastin time (APTT) assay - using factor IX deficient plasma (Werfen, Barcelona, Spain). Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 65-150 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_FactorVIII_procent Assay results for standard coagulation test (Factor VIII) Assay results for standard coagulation test (Factor VIII) - using a Coamatic factor VIII kit (Chromogenix, Bedford, USA) for chromogenic determination of factor VIII activity in human citrated plasma. Run on the ACL TOP CTS 700 (Werfen; Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 50-150 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_FactorV_procent Assay results for standard coagulation test (Factor V) Assay results for standard coagulation test (Factor V) - human plasma immunodepleted of factor V for the quantitaive determination of factor V activity based on the prothrombin time (PT) assay - using factor V deficient plasma (Werfen, Bedford, USA). Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 62-139 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_FactorXIIIAg_procent Assay results for standard coagulation test (Factor XIII) Assay results for standard coagulation test (Factor XIII) - measured with Chromogenix factor XIII Antigen kit (Chromogenix, Bedford, USA) based on an automated latex enhanced immunoassay techniques. Run on the ACL TOP CTS 700 (Werfen; Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 75.2-154.8 Reference: Chromogenix® package insert
CentralHaemostasis.Coagulationparameter_Plasminogen_procent Assay results for standard coagulation test (Plasminogen) Assay results for standard coagulation test (Plasminogen) - Plasminogen in human citrated plasma measured with an automated chromogenic assay technology using the HemosIL® Plasminogen kit (Werfen, Bedford, USA). Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 80-133 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_ProteinC_procent Assay results for standard coagulation test (Protein C) Assay results for standard coagulation test (Protein C) - Protein C in human citrated plasma measured with an automated chromogenic assay technology using the HemosIL® Protein C kit (Werfen, Bedford, USA). Run on the ACL TOP CTS 700 (Werfen; Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 70-140 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_ProteinS_procent Assay results for standard coagulation test (Protein S) Assay results for standard coagulation test (Protein S) - using the HemosIL® Protein S Activity kit (Werfen, Bedford, USA). Determination of the functional acitivty of free Protein S by measuring the degree of prolongation of a prothrombin time in the presence of recombinant human tissue factor, phospholipids, calcium ions and protein C. Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 63.5-149 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_vWFAg_A_B_AB_procent Assay results for standard coagulation test (von Willebrand Factor Antigen) in patients with bloodtype A, B and AB Assay results for standard coagulation test (von Willebrand Factor Antigen) in citrated plasma samples in patients with bloodtype A, B and AB - measured with the HemosIL® von Willebrand Antigen kit (Werfen, Bedford, USA) based on an automated latex enhanced immunoassay technique. Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 66-176 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_vWFAg_BT_0_procent Assay results for standard coagulation test (von Willebrand Factor Antigen) in patients with bloodtype 0 Assay results for standard coagulation test (von Willebrand Factor Antigen) in citrated plasma samples in patients with bloodtype 0 - measured with the HemosIL® von Willebrand Antigen kit (Werfen, Bedford, USA) based on an automated latex enhanced immunoassay technique. Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 42-141 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_vWFA_BT_0_procent Assay results for standard coagulation test (von Willebrand Factor Activity) in patients with bloodtype 0 Assay results for standard coagulation test (von Willebrand Factor Activity) in citrated plasma samples in patients with bloodtype 0 - measured with the HemosIL® von Willebrand Activity kit (Werfen, Bedford, USA) based on an automated latex enhanced immunoassay technique. Run on the ACL TOP CTS 700 (Werfen; Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 40-126 Reference: HemosIL® package insert
CentralHaemostasis.Coagulationparameter_vWFA_BT_A_B_AB_procent Assay results for standard coagulation test (von Willebrand Factor Activity) in patients with bloodtype A, B and AB Assay results for standard coagulation test (von Willebrand Factor Activity) in citrated plasma samples in patients with bloodtype A, B and AB - measured with the HemosIL® von Willebrand Activity kit (Werfen, Bedford, USA) based on an automated latex enhanced immunoassay technique. Run on the ACL TOP CTS 700 (Werfen, Barcelona, Spain). Coagulationparameter were performed by the Institute of Transfusion Medicine (ITM), Cologne-Merheim Medical Centre. Normal range: 49-163 Reference: HemosIL® package insert
CentralHaemostasis.CollectionDate Collection date of the Central Haemostatis sample Collection Date and Time of the central haemostatis sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
CentralHaemostasis.CollectionTime Collection time of the Central Haemostatis sample Collection Date and Time of the central haemostatis sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
CentralHaemostasis.EDTAAliquotID1 Central Haemostasis EDTA aliquot 1 Central Haemostasis EDTA aliquot 1: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml an d1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.CitrateAliquotID)
CentralHaemostasis.EDTAAliquotID2 Central Haemostasis EDTA aliquot 2 Central Haemostasis EDTA aliquot 2: The Haemostasis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood inot 1x 2.7ml potassium EDTA tube and 1x 10ml an d1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostasis.CitrateAliquotID)
CentralHaemostasis.Fibrinolysisregulator_Antiplasmin_Prozent Assay results for Antiplasmin Assay results for Antiplasmin - measured with a colorimetric assay technology (STA-Stachrom®-TAFI-Kit, Stago; France). Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna). Normal range: 80-120 Reference: STA-Stachrom®-TAFI-Kit package insert
CentralHaemostasis.Fibrinolysisregulator_TAFI_procent Assay results for Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Assay results for Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) -measured with a colorimetric assay technology (STA-Stachrom-TAFI-Kit, Stago; France). Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna). Detection limit of Stachrom-TAFI-Kit: 5-195
CentralHaemostasis.Fibrinolysis_FibrinogenMonomer_ug_ml Assay results for fibrin monomers Assay results for fibrin monomers -using an immunoturbidimetric determination technology (STA - Liatest FM-Kit, Stago; France). Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna). Reference interval of Liatest FM-Kit of 6
CentralHaemostasis.FreezerMinusEightyDate Date the Central Haemostasis sample was stored in a -80 freezer All processed haemostatis samples should be stored at -80°C with a needle to freezer time preferably within 2 hours. This variable reflects the date and time that the sample was stored in a minus 80 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
CentralHaemostasis.FreezerMinusEightyTime Time the Central Haemostasis sample was stored in a -80 freezer All processed haemostatis samples should be stored at -80°C with a needle to freezer time preferably within 2 hours. This variable reflects the date and time that the sample was stored in a minus 80 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
CentralHaemostasis.FreezerMinusTwentyDate Date the Central Haemostasis sample was stored in a -20 freezer All processed haemostatis samples should be stored at -80°C with a needle to freezer time preferably within 2 hours. However, if a -80°C freezer was not immediately accessible, samples could be temporarely (max 48 hours) stored in a minus 20°C non-frost-free freezer. This variable reflects the date and time that the sample was stored in a minus 20 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
CentralHaemostasis.FreezerMinusTwentyTime Time the Central Haemostasis sample was stored in a -20 freezer All processed haemostatis samples should be stored at -80°C with a needle to freezer time preferably within 2 hours. However, if a -80°C freezer was not immediately accessible, samples could be temporarely (max 48 hours) stored in a minus 20°C non-frost-free freezer. This variable reflects the date and time that the sample was stored in a minus 20 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
CentralHaemostasis.PAI1_ng_ml Assay results for Plasminogen-activator-inhibitor-1 (PAI-1) Assay results for Plasminogen-activator-inhibitor-1 (PAI-1) - using an ELISA Duo Set Kit from R&D Systems (Minneapolis, USA) based on the sandwich principle according to manufacturer’s instructions. EDTA plasma samples were used. Run on the EPOCH 2 (BioTek; Winooski, USA) microplate reader at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.SampleId Sample identifier for the Central Haemostasis sample The Haemostatis samples are complementary to the routine hospital tests and performed only in a selected number of sites. This involved the collection of blood into 1x 2.7ml potassium EDTA tube and 1x 10ml and 1x 5 ml sodium-citrate tubes (only for a limited number of ADM and ICU patients in selected sites). Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU patients (no potassium EDTA sample at these sampling points). Tubes were centrifuged at 1500g for 10 minutes after collection. 7x 1ml citrate plasma was then aliquoted into 1.8ml cryovials (see also CentralHaemostatis.CitrateAliquotID)
CentralHaemostasis.Syndecan1_pg_ml Assay results for Syndecan-1 Assay results for Syndecan-1 - using an ELISA Duo Set Kit from R&D Systems (Minneapolis, USA) based on the sandwich principle according to manufacturer’s instructions. EDTA plasma samples were used. Run on the EPOCH 2 (BioTek; Winooski, USA) microplate reader at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CentralHaemostasis.Thrombingeneration_ETP_nm_min Assay results for endogenous thrombin potential in citrated plasma (ETP) Assay results for endogenous thrombin potential (ETP) (STG®-BleedScreen, Stago, France) in citrated plasma - using a fluorogenic method (ST Genesia analyzer; Stago, France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_ETP_procent Assay results for endogenous thrombin potential in citrated plasma (ETP) Assay results for endogenous thrombin potential (ETP) (STG®-BleedScreen, Stago, France) in citrated plasma - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_LagTime_min Assay results for quantitative determination of thrombin generation in citrated plasma (Lag Time) Assay results for quantitative determination of thrombin generation (STG®-BleedScreen, Stago, France) in citrated plasma (Lag Time) - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_LagTime_ratio Assay results for quantitative determination of thrombin generation in citrated plasma (Lag Time) Assay results for quantitative determination of thrombin generation (STG®-BleedScreen, Stago, France) in citrated plasma (Lag Time) - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_PeakHeight_nm Assay results for quantitative determination of thrombin generation in citrated plasma (Peak height) Assay results for quantitative determination of thrombin generation (STG®-BleedScreen, Stago, France) in citrated plasma (Peak Height) - using a fluorogenic method (ST Genesia analyzer Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_PeakHeight_procent Assay results for quantitative determination of thrombin generation in citrated plasma (Peak height) Assay results for quantitative determination of thrombin generation (STG®-BleedScreen, Stago, France) in citrated plasma (Peak Height) - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_StartTail_min Assay results for quantitative determination of thrombin generation in citrated plasma (Start Tail) Assay results for quantitative determination of thrombin generation in citrated plasma (Start Tail) - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_StartTail_ratio Assay results for quantitative determination of thrombin generation in citrated plasma (Start Tail) Assay results for quantitative determination of thrombin generation in citrated plasma (Start Tail) - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_TimetoPeak_min Assay results for quantitative determination of thrombin generation in citrated plasma (Time to Peak) Assay results for quantitative determination of thrombin generation in citrated plasma (Time to Peak) - using a fluorogenic method (ST Genesia analyzer; Stago, France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_TimetoPeak_ratio Assay results for quantitative determination of thrombin generation in citrated plasma (Time to Peak) Assay results for quantitative determination of thrombin generation in citrated plasma (Time to Peak) - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_Vel_Index_nm_min Assay results for quantitative determination of thrombin generation in citrated plasma (Velocity Index) Assay results for quantitative determination of thrombin generation in citrated plasma (Velocity Index) - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Thrombingeneration_Vel_Index_procent Assay results for quantitative determination of thrombin generation in in citrated plasma (Velocity index) Assay results for quantitative determination of thrombin generation in in citrated plasma (Velocity index) - using a fluorogenic method (ST Genesia analyzer, Stago; France) - triggered by a low concentration of tissue factor. Measurement were performed at the Ludwig Boltzman Institute (Salzburg, Vienna).
CentralHaemostasis.Timepoints Timepoint
CentralHaemostasis.UsedCitratAliquot1_Microparticles Sample identifier for the used citrat aliquot 1 (Microparticles)
CentralHaemostasis.UsedCitratAliquot1_ThrombinFibrinregu Sample identifier for the used citrat aliquot 1 (Thropmbin/Fibrin)
CentralHaemostasis.UsedCitratAliquot2_Microparticles Sample identifier for the used citrat aliquot 2 (Microparticles)
CentralHaemostasis.UsedCitratAliquot2_ThrombinFibrinregu Sample identifier for the used citrat aliquot 1 (Thropmbin/Fibrin)
CentralHaemostasis.UsedCitrateAliquot_Coagulationparameter Sample identifier for the used citrat aliquot (Coagulation parameter)
CentralHaemostasis.UsedEDTAAliquot1_ELISA Sample identifier for the used EDTA aliquot 1
CentralHaemostasis.UsedEDTAAliquot2_ELISA Sample identifier for the used EDTA aliquot 2
CentralHaemostasis.VECadherin_ng_ml Assay results for VE-Cadherin Assay results for VE-Cadherin - using an ELISA Duo Set Kit from R&D Systems (Minneapolis, USA) based on the sandwich principle according to manufacturer’s instructions. EDTA plasma samples were used. Run on the EPOCH 2 (BioTek; Winooski, USA) microplate reader at Institute for Research in Operative Medicine (IFOM, Cologne, Germany), University Witten/Herdecke.
CTMRI.CTAcuteSubdurHema Intracranial lesions: Acute subdural haematoma 0 == No
1 == Small
2 == Large (mass)
88 == Unknown
Assessment by clinician/investigator whether or not in his/her interpretation an acute subdural hematoma is present. Also, the size (not quantified) is requested to be estimated.
CTMRI.CTAngulation Angulation 1 == No angulation (volume scan)
2 == Orbital-meatal line
99 == Other
This variable describes if a CT scan is performed with or without angulation. There are three options: no angulation (volume scan), orbital-meatal line and other. There is a risk of different interpretation, since there was no definition.
CTMRI.CTBasalCisternsAbsentCompressed Basal cisterns absent compressed 0 == No
1 == Yes
Assessment by clinician/investigator whether or not in his/her interpretation the basal cisterns are compressed.
CTMRI.CTContusion Intracranial lesions: Contusion 0 == No
1 == Small
2 == Large (mass)
88 == Unknown
Assessment by clinician/investigator whether or not in his/her interpretation an intracerebral hematoma/contusion is present. Also, the size (not quantified) is requested to be estimated.
CTMRI.CTDeprSkullFract Depressed skull fracture 0 == No
1 == Closed
2 == Open (compound)
Assessment by clinician/investigator whether or not in his/her interpretation a depressed skull fracture is present. In addition, when present, clinician/investigator has to document whether the fracture is associated with an open wound or not (compound vs closed)
CTMRI.CTDone CT done or not This variable is populated when a CT has been made. Intent to perform a CT was an inclusion criterium for the study. All Images performed have been uploaded to the Imaging repository at Icometrix. Central review of initial and follow-up scans has been done by icometrix. Data of Central review are recorded separately. The variables below capture results of basic scoring by Investigators - these scores inform clinical decision making!
CTMRI.CTERReason Reason for CT (ER only) 1 == GCS <= 14
2 == GCS = 15 + risk factors
3 == Head wound
4 == Exclusion of abnormalities prior to discharge
5 == Suspicion of maxillofacial injury
99 == Other
88 == Unknown
WHY question: reason for performing CT; only applicable to initial scan (presentation).
CTMRI.CTERReasonOther Other reason for CT (ER only) Specification, only applicable if "CTMRI.CTERReason" was "other"
CTMRI.CTExtraduralHema Intracranial lesions: Extradural haematoma 0 == No
1 == Small
2 == Large (mass)
88 == Unknown
Assessment by clinician/investigator whether or not in his/her interpretation an acute extradural/epidural hematoma is present. Also, the size (not quantified) is requested to be estimated.
CTMRI.CTICLesionDAI Intracranial lesions: Small hyper dense lesions (DAI) 0 == No
1 == Yes
88 == Unknown
Assessment by clinician/investigator whether or not in his/her interpretation diffuse axonal injury is present.
CTMRI.CTIschemia Ischemia 1 == Single arterial territory
2 == Multiple territories
3 == Hemisphere
0 == No
Assessment by clinician/investigator whether or not in his/her interpretation ischemia is present. Only applicable for clinical follow-up CT, not applicable to initial CT. In addition, the severity, in terms of how many arterial territories have ischemia, is requested to be answered.
CTMRI.CTManuf CT scanner manufacturer HITA == Hitachi
GE == GE
CARE == Carestream
AGFA == Agfa
KONI == Konica Minolta
PHIL == Philips
SIEM == Siemens
TOSH == Toshiba
99 == Other
This variable describes the CT scans manufacturer.
CTMRI.CTMidlineShift Midline shift present 0 == No
1 == Yes
Assessment by Investigator
CTMRI.CTMidlineShiftMeasure Midline shift Assessment by Investigator
CTMRI.CTMRICompleteStatus CTMRI form complete status NOSTART == Not Started
PRO == In Process
COM == Complete
NOT == Queries Outstanding
INCPT == Incompletable - Pt Factors
INCNOSHOW == Incompletable - No Show
This variable is populated when the CRF status is "complete".
CTMRI.CTMRIDate Date of imaging Date of Imaging captured in CRF
CTMRI.CTMRITime Time of imaging Time of imaging captured in CRF
CTMRI.CTNoOpMotiv Motivation for not scheduling operation 0 == No surgical lesion
1 == Lesion present, but Acceptable/good neurologic condition
2 == Lesion present, but Guideline adherence
3 == Lesion present, but Little/no mass effect
4 == Lesion present, but Not hospital policy
5 == Lesion present, but Extremely poor prognosis
6 == Lesion present, but Brain Death
7 == Lesion present, but Old age
8 == Lesion present, but Wish family, relative or Legal representative
99 == Lesion present, but Other
88 == Unknown
WHY question: documents reason for not having an indication for (intra)cranial surgery.
CTMRI.CTNoOpMotivOther Specify 'other' motivation for not scheduling operation Specification, only applicable if "CTMRI.CTNoOpMotiv" was "other"
CTMRI.CTPatientLocation Patient location at time of CT ED == ER
ADMIS == Ward/Admission
ICU == ICU
This variable describes the in-hospital location of the patient when the CT-scan was performed and was not meant to describe the location of the CT-scanner. Three options: ER, Ward/Admission, ICU
CTMRI.CTReason Main reason for CT scan SFU == Standard follow-up
POC == Post-operative control
CD == Clinical deterioration
IICP == (Suspicion of) Increasing ICP
LOP == Lack of improvement
ICUADM99 == Other
ICUADM88 == Unknown
This variable contains the main reason why a CT-scan, during hospital stay, was performed. One of following options: standard follow-up, post-operative control, clinical deterioration, (suspicion of) increasing ICP, lack of improvement, unknown, other (specified in CTMRI.CTReasonOther) The reason for making an early CT-scan/ER scan can be found in: CTMRI.CTERReason
CTMRI.CTReasonOther Specify 'other' main reason for CT scan This variable contains the main reason why a CT-scan, during hospital stay, was performed. When the "other" option was selected in variable CTMRI.CTReason, investigators could write the reason in this free text variable. The reason for making an early CT-scan/ER scan can be found in: CTMRI.CTERReason
CTMRI.CTRiskFactorsERAgeGreatrThanEqual60 Risk factors: Age >= 60 This variable describes the presence of risk factors (here: age greater than or equal to 60 years) for structural abnormalities on an early CT/MRI. Information for this variable was meant to be only entered for early CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERAlterationOfConsc Risk factors: Alteration of consciousness This variable describes the presence of risk factors (here: alteration of consciousness) for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERAnticoagTx Risk factors: Anticoagulant Tx This variable describes the presence of risk factors (here: use of anticoagulant Tx ) for structural abnormalities on an early CT/MRI. Information for this variable was meant to be only entered for early CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERAnyNeuroDef Risk factors: Any neurological deficit This variable describes the presence of risk factors (here: 'any neurological deficit') for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERClinSignsOfFractSkullBaseVault Risk factors: Clinical signs of fracture skull base or vault This variable describes the presence of risk factors (here: 'clinical signs of fracture skull base or vault') for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15+risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERContusionFace Risk factors: Contusion of the face This variable describes the presence of risk factors (here: 'contusion of the face') for structural abnormalities on an early CT/MRI. Information for this variable was meant to be only entered for early CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERFallFromAnyElev Risk factors: Fall from any elevation This variable describes the presence of risk factors (here: fall from any elevation) for structural abnormalities on an early CT/MRI. Information for this variable was meant to be only entered for early CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERHeadache Risk factors: Headache This variable describes the presence of risk factors (here: headache) for structural abnormalities on an early CT/MRI. Information for this variable was meant to be only entered for early CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERIntoxication Risk factors: Intoxication This variable describes the presence of risk factors (here: intoxication) for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15+risk factors". However due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERLOC Risk factors: Loss of consciousness This variable describes the presence of risk factors (here: loss of consciousness) for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsEROther Risk factors: Other This variable describes the presence of risk factors (other reason, not specified elsewhere) for structural abnormalities on an early CT/MRI. Information for this variable was meant to be only entered for early CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsEROtherTxt Specify other risk factors This variable describes the presence of risk factors (other reason, not specified elsewhere: textfield) for structural abnormalities on an early CT/MRI. Information for this variable was meant to be only entered for early CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERPhysEvidTraumaHeadSkull Risk factors: Physical evidence of trauma to head/skull This variable describes the presence of risk factors (here: physical evidence of trauma to head/skull) for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERPTAGreatrThanEqual4hrs Risk factors: PTA >= 4 hours This variable describes the presence of risk factors (here: PTA >= 4 hours) for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERSeizure Risk factors: Seizure This variable describes the presence of risk factors (here: seizure) for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERSignsFacialFract Risk factors: Signs of facial fracture This variable describes the presence of risk factors (here: signs of facial fracture) for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERVomit Risk factors: Vomiting This variable describes the presence of risk factors (here: vomiting) for structural abnormalities on an initial/ER CT/MRI. Information for this variable was meant to be only entered for initial/ER CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTRiskFactorsERVulnRoadUser Risk factors: Vulnerable road user (pedestrian or cyclist) This variable describes the presence of risk factors (here: vulnerable road users, like pedestrians or cyclists) for structural abnormalities on an early CT/MRI. Information for this variable was meant to be only entered for early CT, when CTMRI.CTERReason = "GCS = 15 + risk factors". However, due to the e-CRF lay-out, it will also be populated for patients with CTMRI.CTERReason is not "GCS = 15 + risk factors" or patients with an MRI.
CTMRI.CTScannerType Type of CT scanner 320 == 320-slice
256 == 256-slice
128 == 128-slice
64 == 64-slice
32 == 32-slice
16 == 16-slice
99 == Other
This variable specifies the type of CT-scanner by the number of slices.
CTMRI.CTSchedForOp Scheduled for operation 0 == No
1 == Yes
Whether or not the patient is scheduled for (intra)cranial surgery. The main aim here is to capture whether the clinical team taking care of the patient sees a neurosurgical indication.
CTMRI.CTSubarachnoidHem Subarachnoid hemorrhage 0 == No
1 == Basal
2 == Cortical
3 == Basal and Cortical
Assessment by clinician/investigator whether or not in his/her interpretation subarachnoid hemorrhage is present. In addition, the location of the hemorrhage is requested to be answered.
CTMRI.CTType Type of CT done (PCT, CTA, CCT, NCCT) NCCT == Non-contrast CT
CCT == Contrast CT
CTA == CT Angiography
PCT == Perfusion CT
This variable describes the type of CT scan that has been made. Multiple options can be selected from: Non-contrast CT, Contrast CT, CT Angiography, Perfusion CT.
CTMRI.CTYesOpMotiv Motivation for scheduling operation 1 == Emergency/life saving
2 == Clinical deterioration
3 == Mass effect on CT
4 == Radiological progression
5 == (Suspicion of) raised ICP
6 == Guideline adherence
7 == To prevent deterioration
8 == Depressed skull fracture
99 == Other
WHY question: documents reason for having an indication for (intra)cranial surgery.
CTMRI.CTYesOpMotivOther Specify 'other' motivation for scheduling operation Free text if "CTMRI.CTYesOpMotiv" was marked as 'Other'. Relates to the WHY question: documents reason for having an indication for (intra)cranial surgery.
CTMRI.IcometrixImageId Icometrix image ID Identifier generated for an imaging experiment when images are uploaded from site It's recommended to use: Imaging.CRFIcometrixImageId
CTMRI.IcometrixPassedQA Passed QA in Icometrix 1 == Yes
0 == No
Reflects if images uploaded from site passed QA of icometix. It's recommended to use: Imaging.CRFIcometrixPassedQA
CTMRI.IcometrixQADateTime Icometrix QA Date/Time Date and time when central QA was done
CTMRI.IcometrixUploadDateTime Date/Time of image upload to Icometrix Date and time when the images were uploaded from site
CTMRI.InitialDataIcometrix Data initially loaded from Icometrix Reflects if the imaging data was initially loaded from Icometrix into the e-CRF (if not, it means the data in the e-CRF was entered manually by the study nurse) It's recommended to use "Imaging.CRFInitialDataIcometrix"
CTMRI.MRIDone MRI done or not This variable is populated when an MRI has been made. MR studies according to study protocol have been performed by selected sites. In addition, results of any MR performed for clinical reasons are captured in the e-CRF. Many of these clinical MR's have also been uploaded to Icometrix.
CTMRI.MRIERReason Reason for MRI (ER only) ER4 == ER only: Suspicion spinal cord lesion
ER2 == ER only: Suspicion non-metal foreign object
ER3 == ER only: Instead of CT (limiting radiation exposure)
ER1 == ER only: Discrepancy between clinical symptomatology and (lack of) CT abnormalities
99 == Other
88 == Unknown
This variable contains the main reason why an MRI, ultra-early MR (within 72 hrs), was performed. Possible options are ER only: Discrepancy between clinical symptomatology and (lack of) CT abnormalities; suspicion non­metal foreign object; instead of CT (limiting radiation exposure); suspicion spinal cord lesion; unknown; other (further specified in text field CTMRI.MRIERReasonOther. Reasons for clinical MRI's can be found in variable CTMRI.MRIReason
CTMRI.MRIERReasonOther Other reason for MRI (ER only) This variable contains the main reason why an MRI, ultra-early MR (within 72 hrs), was performed, when in CTMRI.MRIERReason, the "other" option was chosen. This is a free text field. Reasons for clinical MRI's can be found in variable CTMRI.MRIReason
CTMRI.MRIManuf MRI manufacturer 99 == Other
TOSH == Toshiba
GE == GE
PHIL == Philips
SIEM == Siemens
This variable describes the MRI-scan manufacturer. It's recommended to use "Imaging.CRFMRIManuf"
CTMRI.MRIPatientLocation Patient location at time of MRI ICU == ICU
ED == ER
ADMIS == Ward/Admission
This variable describes the in-hospital location of the patient when the MRI-scan was performed and was not meant to describe the location of the MRI-scanner. Three options: ER, Ward/Admission, ICU
CTMRI.MRIReason Main reason for MRI scan STUDYPROT == Study protocol
88 == Unknown
99 == Other
ICUADM1 == Discrepancy between CT and clinical condition
ICUADM2 == Standard Care
ICUADM3 == Detection of brainstem lesions
This variable contains the main reason why an MRI, during hospital stay, was performed. One of following options must be selected: discrepancy between CT and clinical condition, standard care, detection of brainstem lesions, study protocol, unknown, other (specified in CTMRI.MRIReasonOther). The reason for making an early MRI/ER MRI scan can be found in: CTMRI.MRIERReason It's recommended to use Imaging.CRFMRIReason
CTMRI.MRIReasonOther Specify 'other' main reason for MRI scan This variable contains the main reason why an MRI, during hospital stay, was performed, when in the variable CTMRI.MRIReason, the option "other" was chosen. This is a text field. The reason for making an early MRI/ER MRI scan can be found in: CTMRI.MRIERReason It's recommended to use Imaging.CRFMRIReasonOther
CTMRI.MRIResultPreExistAbnorm Pre-existing abnormalities 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there are pre-existing abnormalities present on MRI scan (yes, no, unknown). Assessment by investigator and or physician. It’s recommended to use Imaging.CRFMRIResultPreExistAbnorm
CTMRI.MRIResultTraumaticAbnorm Traumatic abnormalities 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there are traumatic abnormalities present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRIResultTraumaticAbnorm
CTMRI.MRIScannerStrength Scanner strength This variable describes the MRI scanner strength. This is a text field. It’s recommended to use Imaging.CRFMRIScannerStrength
CTMRI.MRISequences MRI sequences (T1, T2 FLAIR, DWI, GRE, SWI, DTI, MRSI, PWI) T1 == T1
T2 == T2
FLAIR == FLAIR
DWI == DWI
GRE == GRE
SWI == SWI
DTI == DTI
MRSI == MRSI
PWI == PWI
99 == Other
This variable describes the MRI sequence. Options are: T1, T2, FLAIR, DWI, GRE, SWI, DTI, MRSI, PWI, Other. Multiple options can be selected. It’s recommended to use Imaging.CRFMRISequences
CTMRI.MRITraumAbnormASDH ASDH 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there is an acute subdural hematoma present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormASDH
CTMRI.MRITraumAbnormContusion Contusions 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there is a contusion present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormContusion
CTMRI.MRITraumAbnormDAI DAI 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there is DAI (diffuse axonal injury) present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAI
CTMRI.MRITraumAbnormDAILesionLocBrainstem Brainstem 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there is a brain stem lesion present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAILesionLocBrainstem
CTMRI.MRITraumAbnormDAILesionLocCorpusCallosum Corpus Callosum 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there is a corpus callosum lesion present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAILesionLocCorpusCallosum
CTMRI.MRITraumAbnormDAILesionLocDiffuseWhiteMatter Diffuse white matter 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there is a lesion in diffuse white matter present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAILesionLocDiffuseWhiteMatter
CTMRI.MRITraumAbnormDAINumLesions Number of lesions 1 == 1
2 == 2
3 == 3
4 == 4
5 == >= 5
This variable describes how many DAI lesions are present on MRI scan (1,2,3,4,>=5). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAINumLesions
CTMRI.MRITraumAbnormEDH EDH 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there is an epidural hematoma present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormEDH
CTMRI.MRIType Type of MRI done (MRI, MRA) MRA == MRA
MRI == MRI
This variable describes the type of MRI scan that has been made. Options are: MRI, MRA It’s recommended to use Imaging.CRFMRIType
CTMRI.Timepoint Timepoint MR Early == MR Early
CT Post-Op == CT Post-Op
CT Early == CT Early
CT Followup == CT Followup
This variable describes the timepoint of imaging. Options are: CT Early, CT Followup, CT Post­Op, MR Early CT early is considered "first CT". A central review was performed on all CT's. When a Central review is not available this can be due to: - Scan uninterpretable - Scan not available/performed/uploaded Reasons for scan not being available included: o Scan performed in referring hospital and images not available o Pediatric patient and MR performed instead of CT (reducing radiation risk) o Patient too uncooperative to undergo scan, and no indication for sedation.
CTMRI.XRayDone X-ray angiography done This variable is populated when an X-ray angiography has been done.
DailyTIL.TILCCSFDrainageVolume CSF volume drained Specification of volume drained, only applicable if "DailyTIL.TILCSFDrainage" was "yes"
DailyTIL.TILCSFDrainage CSF Drainage 0 == No
1 == Yes
Daily TIL: reflects if CSF drainage occurred yes or no
DailyTIL.TILDailyPhysConcSatisfNotDone Daily physician concerns for 9 aspects Daily physician concerns are documented for 9 aspects rated on a scale of 1 (not concerned) to 10 (very concerned)
DailyTIL.TILDate Date of TIL assessment Interpretation of ICP is not possible without knowledge on the level of therapy intensity employed for ICP control and/or for CPP management. TIL can be recorded in great detail and has commonly been performed on an hourly basis. Such detailed recording however, is resource intensive. Further, ICU practices have changed with most high grade interventions (such as metabolic suppression and temperature manipulation) now being used in a continuous fashion over periods of days or at least a large fraction of a day. Other discrete interventions (such as surgical decompression) happen as a single threshold event rather than as a repeated treatment. Given this context, the use of hourly recording of therapy intensity may be less relevant and there are doubts as to whether the data provided by hourly recording of TIL justifies the investment in time, particularly in the context of an increased (and probably increasing) burden of data collection in other areas (such as imaging and biomarkers). We therefore decided to record the therapy intensity level on a daily basis, under the presumption that this will offer a transparent and useful approach with the benefit of a lower burden than when hourly recording is performed. A novel TIL was developed to this purpose, which requires further validation. Preliminary data have been reported by Zuercher et al: Reliability and Validity of the Therapy Intensity Level Scale: Analysis of Clinimetric Properties of a Novel Approach to Assess Management of Intracranial Pressure in Traumatic Brain Injury; J Neurotrauma. 2016 Oct 1;33(19):1768-1774. Epub 2016 Feb 11. The specified treatment modalities and categories are compatible with the pediatric TIL proposed by Shore et al.: Shore P, Adelson PD, Kochanek P, et al. Reliability and validity of the pediatric intensity level of therapy (pilot) scale: A measure of the use of intracranial pressure-directed therapies. Crit Care Med. 2006;34:1981-1987. Possible chasnges in TIL over a 24 hr period are captured in the reporting of "hourly" values at 4 hr intervals.
DailyTIL.TILDobutamineDose Dobutamine Indicates the total dose of dobutamine administered (in mg.) if applicable. Calculated over a 24-hour period
DailyTIL.TILDopamineDose Dopamine Indicates the total dose of dopamine administered (in mg.) if applicable. Calculated over a 24-hour period
DailyTIL.TILFactorsCaloricIntakeEnteralKcal Enteral caloric intake (please specify) Daily TIL: reflects the caloric intake via Enteral route in Kcal
DailyTIL.TILFactorsCaloricIntakeParenKcal Parenteral caloric intake (please specify) Daily TIL: reflects the caloric intake via Parenteral route in Kcal
DailyTIL.TILFactorsCaloricIntakeRouteEnteral Enteral caloric intake The variables "parenteral" and "enteral route" are used to document if the patient received enteral feeding or not and if so, what the total number of Kcal was given by each route.
DailyTIL.TILFactorsCaloricIntakeRouteParen Parenteral caloric intake The variables "parenteral" and "enteral route" are used to document if the patient received enteral feeding or not and if so, what the total number of Kcal was given by each route.
DailyTIL.TILFactorsCoagHemoglobAfterOtherUnitAmt Level of hemoglobin after transfusion in another unit than the standard g/dL Reflects the level of hemoglobin after transfusion in another unit than the standard g/dL (together with "DailyTIL.TILFactorsCoagHemoglobAfterOtherUnitSpecify")
DailyTIL.TILFactorsCoagHemoglobAfterOtherUnitSpecify Unit used for level of hemoglobin after transfusion (in another unit than the standard g/dL) 1 == mmol/L
99 == Other
Reflects the level of hemoglobin after transfusion in another unit than the standard g/dL (together with "DailyTIL.TILFactorsCoagHemoglobAfterOtherUnitAmt")
DailyTIL.TILFactorsCoagHemoglobBeforeOtherUnitAmt Level of hemoglobin before transfusion in another unit than the standard g/dL Reflects the level of hemoglobin before transfusion in another unit than the standard g/dL (together with "DailyTIL.TILFactorsCoagHemoglobBeforeOtherUnitSpecify")
DailyTIL.TILFactorsCoagHemoglobBeforeOtherUnitSpecify Unit used for level of hemoglobin before transfusion (in another unit than the standard g/dL) 1 == mmol/L
99 == Other
Reflects the level of hemoglobin before transfusion in another unit than the standard g/dL (together with "DailyTIL.TILFactorsCoagHemoglobBeforeOtherUnitAmt")
DailyTIL.TILFactorsCoagulation Coagulation status checked 0 == No
1 == Yes, for clinical reasons
2 == Yes, according to study protocol
88 == Unknown
A maximum of 4 "types" of treatment (drop down box) can be selected and entered under treatment 1-4. Details on volume/dose of the products administered should correspond to treatment 1-4 and be entered in the variable volume 1-4.
DailyTIL.TILFactorsCoagulationHemoglobinAfter Hemoglobin level after transfusion Reflects the level of hemoglobin after transfusion in the standard unit (g/dL)
DailyTIL.TILFactorsCoagulationHemoglobinAfterNotDone Level of hemoglobin after transfusion not recorded Intended to document hemoglobin levels after blood transfusion, this variable would indicate that hemoglobin levels were not documented after transfusion; however, some investigators may have also marked this for patients who did not receive a blood transfusion
DailyTIL.TILFactorsCoagulationHemoglobinBefore Hemoglobin level before transfusion Reflects the level of hemoglobin before transfusion in the standard unit (g/dL)
DailyTIL.TILFactorsCoagulationHemoglobinBeforeNotDone Level of hemoglobin before transfusion not recorded Intended to be only applicable in case the patient received a blood transfusion, however various investigators may have entered "not done", also for patient who did not receive a transfusion
DailyTIL.TILFactorsCoagulationType1 (1) Coagulation product / treatment 1 == Packed red blood cell concentrates (pRBCs)
2 == Fresh whole blood
3 == Fresh frozen plasma (FFP)
4 == Freeze dried plasma / lypholized plasma
5 == Platelet concentrates
6 == PCC (prothrombin complex concentrates)
7 == Fibrinogen concentrate
8 == Albumine
9 == Recombinant factor FVIIa
10 == Tranexamic acid (TXA)
11 == Cryoprecipitate
12 == Desmopression (DDAVP)
13 == Factor XIII
14 == Calcium
Reflects the details on volume/dose of the products administered
DailyTIL.TILFactorsCoagulationType2 (2) Coagulation product / treatment 1 == Packed red blood cell concentrates (pRBCs)
2 == Fresh whole blood
3 == Fresh frozen plasma (FFP)
4 == Freeze dried plasma / lypholized plasma
5 == Platelet concentrates
6 == PCC (prothrombin complex concentrates)
7 == Fibrinogen concentrate
8 == Albumine
9 == Recombinant factor FVIIa
10 == Tranexamic acid (TXA)
11 == Cryoprecipitate
12 == Desmopression (DDAVP)
13 == Factor XIII
14 == Calcium
Reflects the details on volume/dose of the products administered
DailyTIL.TILFactorsCoagulationType3 (3) Coagulation product / treatment 1 == Packed red blood cell concentrates (pRBCs)
2 == Fresh whole blood
3 == Fresh frozen plasma (FFP)
4 == Freeze dried plasma / lypholized plasma
5 == Platelet concentrates
6 == PCC (prothrombin complex concentrates)
7 == Fibrinogen concentrate
8 == Albumine
9 == Recombinant factor FVIIa
10 == Tranexamic acid (TXA)
11 == Cryoprecipitate
12 == Desmopression (DDAVP)
13 == Factor XIII
14 == Calcium
Reflects the details on volume/dose of the products administered
DailyTIL.TILFactorsCoagulationType4 (4) Coagulation product / treatment 1 == Packed red blood cell concentrates (pRBCs)
2 == Fresh whole blood
3 == Fresh frozen plasma (FFP)
4 == Freeze dried plasma / lypholized plasma
5 == Platelet concentrates
6 == PCC (prothrombin complex concentrates)
7 == Fibrinogen concentrate
8 == Albumine
9 == Recombinant factor FVIIa
10 == Tranexamic acid (TXA)
11 == Cryoprecipitate
12 == Desmopression (DDAVP)
13 == Factor XIII
14 == Calcium
Reflects the details on volume/dose of the products administered
DailyTIL.TILFactorsCoagulationVolume1 (1) Coagulation product volume Reflects the details on volume/dose of the products administered
DailyTIL.TILFactorsCoagulationVolume2 (2) Coagulation product volume Reflects the details on volume/dose of the products administered
DailyTIL.TILFactorsCoagulationVolume3 (3) Coagulation product volume Reflects the details on volume/dose of the products administered
DailyTIL.TILFactorsCoagulationVolume4 (4) Coagulation product volume Reflects the details on volume/dose of the products administered
DailyTIL.TILFactorsGenSuppCareDone Blood transfusion, blood products or treatment of coagulopathy received 1 == Yes
0 == No
Reflects whether the patient received any blood transfusion, blood products and treatment of coagulopathy.
DailyTIL.TILFactorsGlucoseManagement Glucose management 0 == No specific therapy
1 == Prophylactic
2 == Insulin administration to correct hyperglycemias
3 == Tight glycemic control (targeting blood glucose levels of 80-110mg/dL [4.4-6.1mmol/L])
Indicates whether glucose management was applied and if so, which therapy used (prophylactic, insulin administration of tight glycemic control).
DailyTIL.TILFever Treatment of fever (temperature > 38 degree Celsius or spontaneous temperature of 34.5 degree Celsius) 0 == No
1 == Yes
Records for the Daily TIL whether there was treatment of fever (temperature <38°C) or spontaneous temperature of 34.5°C
DailyTIL.TILFeverHypothermia Hypothermia below 35 degree Celsius 0 == No
1 == Yes
Records for the Daily TIL whether there was hypothermia below 35°C
DailyTIL.TILFeverMildHypothermia Mild hypothermia for ICP control with a lower limit of 35 degree Celsius 0 == No
1 == Yes
Records for the Daily TIL whether there was mild hypothermia for ICP control with a lower limit of 35°C.
DailyTIL.TILFluidBalanceNotDone Fluid balance not done Indicates that the Fluid Balance was not done.
DailyTIL.TILFluidCalcStartDate Date calculation started Start date Fluid Balance calculation.
DailyTIL.TILFluidCalcStartTime Time calculation started Start Time Fluid Balance calculation.
DailyTIL.TILFluidCalcStopDate Date calculation stopped Stop date Fluid Balance calculation.
DailyTIL.TILFluidCalcStopTime Time calculation stopped Stop Time Fluid Balance calculation.
DailyTIL.TILFluidColloids Were colloids administered? 0 == No
1 == Yes
88 == Unknown
Indicates whether colloids were administered with regard to Fluid Balance.
DailyTIL.TILFluidColloidsTotalVolume Total volume colloids Total volume of colloids administered (in ml)
DailyTIL.TILFluidColloidsType Type of colloid 1 == Albumin 5%
2 == Albumin 20%
3 == Dextran
4 == Gelatin (e.g. gelofusion)
5 == HES (hydroxyethyl starches)
6 == Tetrastarches (e.g. HES 130/04)
Type of colloids administered
DailyTIL.TILFluidIn Fluids in Recorded preferably over 24-hour period, exact details to be derived from start and stop date/time for calculation
DailyTIL.TILFluidLoading Fluid loading for maintenance of cerebral perfusion 0 == No
1 == Yes
Records for the Daily TIL whether there was fluid loading for maintenance of cerebral perfusion.
DailyTIL.TILFluidLoadingVasopressor Vasopressor therapy required for management of cerebral perfusion 0 == No
1 == Yes
Records for the Daily TIL whether there was vasopressor therapy required for management of cerebral perfusion
DailyTIL.TILFluidOutCSFDrain CSF drainage Daily TIL - Number of fluid out: CSF drainage in ml
DailyTIL.TILFluidOutGastric Gastic loss Daily TIL - Number of fluid out: Gastic loss in ml
DailyTIL.TILFluidOutOther Fluid out Daily TIL - Number of fluid out: other fluid (than Urine, Gastic loss or CSF drainage) in ml
DailyTIL.TILFluidOutUrine Urine Daily TIL - Number of fluid out: Urine in ml
DailyTIL.TILFluidsRenalReplacement Need for renal replacement therapy 0 == No
1 == Yes
Indicates for the fluid balance whether there was a need for renal replacement therapy.
DailyTIL.TILHyperosmolarThearpy Hyperosmolar therapy with mannitol up to 2 g/kg/24 hours 0 == No
1 == Yes
Records for the Daily TIL whether there was Hyperosmolar therapy with mannitol up to 2 g/kg/24 hours
DailyTIL.TILHyperosomolarTherapyHigher Hyperosmolar therapy with hypertonic saline > 0.3 g/kg/24 hours 0 == No
1 == Yes
Records for the Daily TIL whether there was Hyperosmolar therapy with hypertonic saline > 0.3 g/kg/24 hours
DailyTIL.TILHyperosomolarTherapyHypertonicLow Hyperosmolar therapy with hypertonic saline up to 0.3 g/kg/24 hours 0 == No
1 == Yes
Records for the Daily TIL whether there was Hyperosmolar therapy with hypertonic saline up to 0.3 g/kg/24 hours
DailyTIL.TILHyperosomolarTherapyMannitolGreater2g Hyperosmolar therapy with mannitol > 2 g/kg/24 hours 0 == No
1 == Yes
Records for the Daily TIL whether there was Hyperosmolar therapy with mannitol > 2 g/kg/24 hours
DailyTIL.TILHypertonicSalineDose Hypertonic saline Indicates the total dose of hypertonic saline administered (in g.) if applicable. Calculated over a 24-hour period.
DailyTIL.TILHyperventilation Mild hypocapnia for ICP control [PaCO2 4.6 - 5.3 kPa (35 - 40 mmHg)] 0 == No
1 == Yes
Records for the Daily TIL whether there was Mild hypocapnia for ICP control [PaCO2 4.6 - 5.3 kPa (35 - 40 mmHg)]
DailyTIL.TILHyperventilationIntensive Intensive hypocapnia for ICP control [PaCO2 < 4.0 kPa (30 mmHg)] 0 == No
1 == Yes
Records for the Daily TIL whether there was Intensive hypocapnia for ICP control [PaCO2 < 4.0 kPa (30 mmHg)]
DailyTIL.TILHyperventilationModerate Moderate hypocapnia for ICP control [PaCO2 4.0 - 4.5 kPa (30 - 35 mmHg)] 0 == No
1 == Yes
Records for the Daily TIL whether there was Moderate hypocapnia for ICP control [PaCO2 4.0 - 4.5 kPa (30 - 35 mmHg)]
DailyTIL.TILICPSurgery Intracranial operation for progressive mass lesion, not scheduled on admission 1 == Yes
0 == No
Records for the Daily TIL whether there was an intracranial operation for progressive mass lesion, not scheduled on admission
DailyTIL.TILICPSurgeryDecomCranectomy Decompressive craniectomy 0 == No
1 == Yes
Records for the Daily TIL whether there was a Decompressive Craniectomy
DailyTIL.TILMannitolDose Mannitol Indicates the total dose of Mannitol administered (in g.) if applicable. Calculated over a 24-hour period
DailyTIL.TILNoradrenalineDose Noradrenaline Indicates the total dose of Noradrenaline administered (in mg.) if applicable. Calculated over a 24-hour period
DailyTIL.TILOtherDose Other vasopressor's dosage (please specify) Indicates the dose (in mg.) of other vasopressors drugs administered (if applicable)
DailyTIL.TILOtherTxt Other vasopressor (please specify) Indicates which other vasopressors drugs was administered (if applicable)
DailyTIL.TILOtherVaso Were there other vasopressors used? 0 == No
1 == Yes
Indicates whether any other Vasopressor drug was administered (other than Dobutamine, Dopamine, Noradrenaline or Phenylephrine)
DailyTIL.TILPhenylephrineDose Phenylephrine Indicates the total dose of phenylephrine administered (in mg.) if applicable. Calculated over a 24-hour period
DailyTIL.TILPhysicianConcernsContusionpregression To what extent does contusion progression concern the treating physician regarding this specific patient's current condition? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to contusion progression. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianConcernsCPP To what extent does CPP concern the treating physician regarding this specific patient's current condition? 2 == 2
1 == 1
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to CPP. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianConcernsEpilepsy To what extent does epilepsy concern the treating physician regarding this specific patient's current condition? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to epilepsy. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianConcernsFocalSwelling To what extent does focal swelling concern the treating physician regarding this specific patient's current condition? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to focal swelling. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianConcernsHematomaProgression To what extent does hematoma progression concern the treating physician regarding this specific patient's current condition? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to hematoma progression. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianConcernsHypoperfusion To what extent does suspected hypoperfusion concern the treating physician regarding this specific patient's current condition? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to suspected hypoperfusion. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianConcernsICP To what extent does ICP concern the treating physician regarding this specific patient's current condition? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to ICP. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianConcernsIntracranialInfection To what extent does intracranial infection concern the treating physician regarding this specific patient's current condition? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to intracranial infections. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianConcernsVasospasm To what extent does vasospasm concern the treating physician regarding this specific patient's current condition? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Reflects daily the physician concern and satisfaction with regard to vasospasm. Scales from 1 (not concerned) to 10 (very concerned)
DailyTIL.TILPhysicianOverallSatisfaction Overall, how satisfied is the physician with the clinical course of this patient? 0 == Not at all
1 == Slightly
2 == Moderately
3 == Quite
4 == Very
This variable aims to capture the overall satisfaction of the physician with the clinical course of this patient; "not at all satisfied" would indicate that the patient did much more poorly than expected; "very satisfied" would indicate that the patient did much better than expected. Physician satisfaction should be assessed on a daily basis,
DailyTIL.TILPhysicianOverallSatisfactionSurvival Overall, what are the short term survival chances of the patient as per the physician? 1 == Much worse
2 == A little worse
3 == Unchanged
4 == A little better
5 == Much better
This variable aims to capture the opinion of the treating physician as to whether the short time survival change have chnged in comparision to the previous assessment
DailyTIL.TILPhysicianSatICP How satisfied are you with the ICP control obtained? 77 == N/A (no ICP monitoring)
1 == Not at all
2 == Slightly
3 == Moderate
4 == Quite
5 == Very
Documents physician satisfaction with ICP control
DailyTIL.TILPosition Head elevation for ICP control 0 == No
1 == Yes
Records for the Daily TIL whether there was head elevation for ICP control
DailyTIL.TILPositionNursedFlat Nursed flat (180 degree) for CPP management 0 == No
1 == Yes
Records for the Daily TIL whether there was a patient position of Nursed flat (180°C) for CPP management
DailyTIL.TILReasonForChange Reason for change in treatment over this day 0 == No change
1 == Intensified: Clinical deterioration
2 == Intensified:Suspicion of increased of ICP (not measured)
3 == Intensified:Increased ICP (documented)
4 == Intensified:Clinical decision to target other mechanism
5 == Intensified:Change of doctor (different shift)
6 == Decreasing:Clinical improvement
7 == Decreasing:Adequate control over ICP
8 == Decreasing:Upper treatment limit reached/past
9 == Decreasing:Further treatment considered futile
10 == Decreasing:Change of doctor (different shift)
Reflects the reason for change in TIL therapy over the day.
DailyTIL.TILSedation Sedation (low dose as required for mechanical ventilation) 1 == Yes
0 == No
Records for the Daily TIL whether there was sedation (low dose as required for mechanical ventilation)
DailyTIL.TILSedationHigher Higher dose sedation for ICP control (not aiming for burst supression) 0 == No
1 == Yes
Records for the Daily TIL whether there was a higher dose sedation for ICP control (not aiming for burst supression)
DailyTIL.TILSedationMetabolic Metabolic suppression for ICP control with high dose barbiturates or propofol 0 == No
1 == Yes
Records for the Daily TIL whether there was metabolic suppression for ICP control with high dose barbiturates or propofol
DailyTIL.TILSedationNeuromuscular Neuromuscular blockade (paralysis) 0 == No
1 == Yes
Records for the Daily TIL whether there was neuromuscular blockade (paralysis)
DailyTIL.TILSedationScaleUsed Was a sedation scale used to adjust sedatives (SAS, RASS, MASS, Ramsay, etc)? 1 == Yes
0 == No
77 == N/A
Reflects with regard to sedation management whether a sedation scale (SAS, RASS, MASS, Ramsay, etc) was used to adjust sedatives?
DailyTIL.TILSedativesInterrupted If the patient is receiving infusions of sedatives (opioids), were they interrupted today? 1 == Yes
0 == No
77 == N/A
Reflects with regard to sedation management whether infusions of sedatives (opioids) were interrupted during the day if the patient was receiving any.
DailyTIL.TILTherapyIntensityNotDone Daily TIL not done Marked if Daily TIL was not done for a patient
DailyTIL.TILTime Time of TIL assessment Time of Daily TIL records. See also "DailyTIL.TILDate"
DailyTIL.TotalTIL Daily TIL total Calculated centrally - 24 hour TILS as the worst sum TILs for each day for the ICU timepoints (day 1-7, 10, 14, 21 and 28)
FollowUp.CTAngulation CT with or without angulation 99 == Other
2 == Orbital-meatal line
1 == No angulation (volume scan)
Reflects the angulation of the Follow up CT.
FollowUp.CTAtrophy Atrophy 88 == Unknown
F == Focal
D == Diffuse
0 == No
CT parameters scored by the investigator: reflects the Atrophy of the Follow up CT.
FollowUp.CTHydrocephalus Hydrocephalus 1 == Yes
88 == Unknown
0 == No
CT parameters scored by the investigator: reflects if there was hydrocephalus or not on the Follow up CT.
FollowUp.CTManuf CT scan manufacturer 99 == Other
TOSH == Toshiba
SIEM == Siemens
PHIL == Philips
KONI == Konica Minolta
HITA == Hitachi
GE == GE
CARE == Carestream
AGFA == Agfa
Manufacturer of the CT scanner used
FollowUp.CTMidlineShift CT midline shift assessed by investigator 0 == No
1 == Yes
CT parameters scored by the investigator: reflects if there was midline shift on the Follow up CT.
FollowUp.CTMidlineShiftMeasure CT midline shift in mm (assessed by investigator) CT parameters scored by the investigator: reflects the volume in mm if there was a midline shift on the Follow up CT Check also "FollowUp.CTMidlineShift"
FollowUp.CTMRIDate Date of follow up imaging captured in CRF Imaging date captured in the CRF for followup images
FollowUp.CTMRITime Time of follow up imaging captured in CRF Imaging time captured in CRF for followup images
FollowUp.CTReason Reason for Follow up CT CD == Clinical deterioration
LOP == Absence of or slow improvement
RFU == Routine follow-up
Reason for follow up CT could be: Clinical deterioration, Absence of or slow improvement, Routine follow­up
FollowUp.CTScannerType Type of scanner for follow up CT 99 == Other
16 == 16-slice
32 == 32-slice
64 == 64-slice
128 == 128-slice
256 == 256-slice
320 == 320-slice
Type of scanner used for follow up CT
FollowUp.CTSubduralHaematomaHygroma Subdural haematoma / hygroma B == Bilateral
L == Left
88 == Unknown
R == Right
0 == No
CT parameters scored by the investigator: reflects if there was subdural haematoma/hygroma on the Follow up CT and if yes, on which side.
FollowUp.CTType Type of Follow up CT done (PCT, CTA, CCT, NCCT) PCT == Perfusion CT
CTA == CT Angiography
CCT == Contrast CT
NCCT == Non-contrast CT
Type of CT scan for followup imaging
FollowUp.FUAttendance In attendance 0 == No attendance
1 == Subject
2 == Proxy (please specify)
3 == Health care professional taking care of patient
4 == N/A (death)
Documents who was present at the follow-up assessment. In case of postal Questionnaire, there would be "no attendance"
FollowUp.FUAttendanceProxyChild Attendance by proxy: Child When a proxy was attending the Follow up visit, specification was needed whether this was: child, parent, partner, sibling or other caretaker. This variable reflects who often the proxy attending the follow up visit was the child of the patient.
FollowUp.FUAttendanceProxyOtherCaretaker Attendance by proxy: Other caretaker When a proxy was attending the Follow up visit, specification was needed whether this was: child, parent, partner, sibling or other caretaker. This variable reflects who often the proxy attending the follow up visit was an other caretaker.
FollowUp.FUAttendanceProxyParent Attendance by proxy: Parent When a proxy was attending the Follow up visit, specification was needed whether this was: child, parent, partner, sibling or other caretaker. This variable reflects who often the proxy attending the follow up visit was a parent of the patient.
FollowUp.FUAttendanceProxyPartner Attendance by proxy: Partner When a proxy was attending the Follow up visit, specification was needed whether this was: child, parent, partner, sibling or other caretaker. This variable reflects who often the proxy attending the follow up visit was the partner of the patient.
FollowUp.FUAttendanceProxySibling Attendance by proxy: Sibling When a proxy was attending the Follow up visit, specification was needed whether this was: child, parent, partner, sibling or other caretaker. This variable reflects who often the proxy attending the follow up visit was a sibling of the patient.
FollowUp.FUDisabilityDueToExtracranialInj Disability due to extracranial injuries 0 == No
1 == Mild/moderate
2 == Severe (requiring institutional care)
The variable is only valid when "FollowUp.FUVitStatus" is "alive". It reflects if the patient suffers from any disability due to an extracranial injury
FollowUp.FUImagingModality Follow up lmaging modality XRay == X-Ray Angiography
MRI == MRI
CT == CT
The variables concerning imaging modality, largely overlap with those with the in-hospital phase, however details of recording abnormalities and reasons for performing the imaging studies differ
FollowUp.FUIntracranialSurg Intracranial surgery 0 == No
1 == Yes
88 == Unknown
Reflects at the follow up visit if any intracranial surgery was performed after discharge
FollowUp.FUIntracranialSurgDate Date of intracranial surgery Date of the Intracranial surgery (after discharge) if performed Check also "FollowUp.FUIntracranialSurg".
FollowUp.FUIntracranialSurgOther Other type of intracranial surgery (please specify) If any form of intracranial surgery was performed after discharge (re-admission likely), this reflects if the type was other (than hydrocephalus, chronic subdural hematoma or cranioplasty)
FollowUp.FUIntracranialSurgSpecifyType Type of intracranial surgery 1 == Hydrocephalus
2 == Chronic subdural hematoma
3 == Cranioplasty
99 == Other
This variable aims to capture any form of intracranial surgery performed after discharge (re-admission likely)
FollowUp.FUIntracranialSurgTime Time of intracranial surgery Time of the Intracranial surgery (after discharge) if performed Check also "FollowUp.FUIntracranialSurg" and "FollowUp.FUIntracranialSurgDate"
FollowUp.FUMartlPartnerStatus Marital status 1 == Never been married
2 == Married
3 == Living together/common law
4 == Divorced
5 == Separated
6 == Widowed
99 == Other
88 == Unknown
Only recorded if change in SES; This variable needs to be related to the pre-injury situation: Subject.MartlPartnerStatus
FollowUp.FUMedAmantidine Amantadine Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAmantidineReason Reason for amantadine 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAntibiotics Antibiotics Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAntibioticsReason Reason for antibiotics 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAntiConv Anticonvulsants Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAntiConvReason Reason for anticonvulsants 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAntidep Antidepressants Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAntidepReason Reason for antidepressants 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAntipsycho Antipsychotic agents Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAntipsychoReason Reason for anti-psychotic agents 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAnxiolytics Anxiolytics Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedAnxiolyticsReason Reason for anxiolytics 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedCholinergic Cholinergic agents Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedCholinergicReason Reason for cholinergic agents 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedClonidine Clonidine Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedClonidineReason Reason for clonidine 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedComplAutonomicInstability Paroxysmal sympathetic hyperactivity (autonomic instability) 1 == Yes
0 == No
88 == Unknown
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects whether there has been Paroxysmal sympathetic hyperactivity (autonomic instability).
FollowUp.FUMedComplAutonomicInstabilityTreatment Treatment of paroxysmal sympathetic hyperactivity (autonomic instability) DRUGS == Drugs
BPUMP == Baclofen pump
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects the treatment given in case there has been Paroxysmal sympathetic hyperactivity (autonomic instability.) See also "FollowUp.FUMedComplAutonomicInstability"
FollowUp.FUMedComplDVT DVT 1 == Yes
0 == No
88 == Unknown
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects whether there has been DVT (Deep venous thrombosis). Intent is to record here only DVT occurring post-discharge. DVT that occurred before/at presentation or during hospital stay is recorded elsewhere: Hospital.HospComplDVT
FollowUp.FUMedComplHeteroOss Heterotopic ossification 1 == Yes
0 == No
88 == Unknown
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects whether there has been Heterotopic ossification.
FollowUp.FUMedComplHeteroOssTreatment Treatment of heterotopic ossification PERF == Performed
PLAN == Planned
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects the treatment given in case there has been Heterotopic ossification. See also "FollowUp.FUMedComplHeteroOss".
FollowUp.FUMedComplPressureSores Pressure sores 1 == Yes
0 == No
88 == Unknown
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects whether there has been Pressure sores.
FollowUp.FUMedComplPulmonaryEmbolus Pulmonary embolus 1 == Yes
0 == No
88 == Unknown
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects whether there has been Pulmonary embolism (PE) post-discharge. PE that occurred before/at presentation or during hospital stay is recorded elsewhere: Hospital.HospComplPumlEmb
FollowUp.FUMedComplSeizurePostDischarge Seizures 1 == Yes
0 == No
88 == Unknown
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects whether there has been seizures occurring post-discharge. Seizures that occurred before/at presentation or during hospital stay are recorded elsewhere: InjuryHx.EDComplEventSeizures; Vitals.HosComplEventSeizures; Hospital.HospComplSeizures; Vitals.HosComplEventSeizures; Hospital.ICUDisComplSeizure; Outcomes.GOSEEpilepsyFits; Subjective reporting also in: Outcomes.PartQuestACurHltSeiz
FollowUp.FUMedComplSpasticity Spasticity 1 == Yes
0 == No
88 == Unknown
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects whether there has been spasticity.
FollowUp.FUMedComplSpasticityTreatment Treatment for spasticity BENZ == Benzodiazepines
OBAC == Oral baclofen
IBAC == Intrathecal baclofen pump
PHYS == Physiotherapy
On follow-up assessment, information is captured on medical complications and sequelae post-hospitalization. This reflects the treatment given in case there has been spasticity.
FollowUp.FUMedication Medication 0 == No
1 == Yes
88 == Unknown
On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this. No specific info on agent or dose is captured.
FollowUp.FUMedNarc Narcotics Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedNarcReason Reason for narcotics 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedOther Other medication Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedOtherPain Other pain medication Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedOtherPainReason Reason for other pain medication 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedOtherReason Reason for other medication 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this. Only applicable if "FollowUp.FUMedication = Yes" and "FollowUp.FUMedOther" marked as valid.
FollowUp.FUMedOtherText Other medication (please specify) Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedPsycho Psycho-stimulants Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedPsychoReason Reason for psycho-stimulants 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedSteroids Steroids Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUMedSteroidsReason Reason for steroids 1 == Agitation
2 == Attentional problems
3 == Behavioral disturbance
4 == Depression
5 == Memory difficulties
6 == Disorder of consciousness
7 == Fatigue
8 == Infection
9 == Pain - somatic
10 == Pain - neurogenic
11 == Pain - headache/migraine
12 == Paroxysmal sympathetic hyperactivity (PSH)
13 == Seizure - prophylaxis
14 == Seizure - treatment
15 == Spasticity
Only applicable if FollowUp.FUMedication = Yes. On Follow-up assessment, general information is captured on classes of medication taken and the reason for taking this.
FollowUp.FUPrincipalDeathCause Principle cause of death 1 == Head injury/initial injury
2 == Head injury/secondary intracranial damage
3 == Systemic trauma
4 == Medical complications
88 == Unknown
99 == Other
On Follow-up assessment, information is captured whether the patience is still alive or not. This reflects the (post-hospitalization) death cause if the patient died post-discharge. Only applicable if FollowUp.FUVitStatus = Dead.
FollowUp.FUPrincipalDeathCauseOther Other principal cause of death (please specify) On Follow-up assessment, information is captured whether the patience is still alive or not. This reflects the (post-hospitalization) death cause if the patient died post-discharge (if the cause was "other" than listed). Only applicable if FollowUp.FUVitStatus = Dead. See also "FollowUp.FUPrincipalDeathCause"
FollowUp.FUPtStillInICU Is the patient still in ICU? This variable reflects if the patient was still in ICU at the time of a scheduled follow up visit.
FollowUp.FUReasonNoAttendance Reason for no attendance 99 == Other
3 == Refused
1 == Not contactable
2 == Forgotten
Documents reason if subject did not undergo Follow up assessment.
FollowUp.FURehabGenLongTermAcuteCUInPat Type of in-patient rehabilitation unit: General long term acute care Reflects the type of in-patient rehab care received: General long term acute care
FollowUp.FURehabGenRehabUnitInPat Type of in-patient rehabilitation unit: General Reflects the type of in-patient rehab care received: General
FollowUp.FURehabGeriatricRehabUnitInPat Type of in-patient rehabilitation unit: Geriatric Reflects the type of in-patient rehab care received: Geriatric
FollowUp.FURehabInPat In rehabilitation Documents that patient received in-patient rehab care at the time of this assessment.
FollowUp.FURehabInPatAdmisDate Date of admission to in-patient rehabilitation Date of admission for the in-patient rehab care.
FollowUp.FURehabInPatDischDate Date of discharge from in-patient rehabilitation Date of discharge for the in-patient rehab care.
FollowUp.FURehabInPatOngoingRehab Is in-patient rehabilitation ongoing? 1 == Yes
0 == No
Reflects if the in-patient rehab was still ongoing at the time of the follow up assessment.
FollowUp.FURehabInPatShortTermInterrup1EndDate First short-term rehabilitation interruption end date Only applicable in case the inpatient rehab was interrupted for specific reasons
FollowUp.FURehabInPatShortTermInterrup1StartDate First short-term rehabilitation interruption start date Only applicable in case the inpatient rehab was interrupted for specific reasons
FollowUp.FURehabInPatShortTermInterrup2EndDate Second short-term rehabilitation interruption end date Only applicable in case the inpatient rehab was interrupted for specific reasons
FollowUp.FURehabInPatShortTermInterrup2StartDate Second short-term rehabilitation interruption start date Only applicable in case the inpatient rehab was interrupted for specific reasons
FollowUp.FURehabInPatShortTermInterrup3EndDate Third short-term rehabilitation interruption end date Only applicable in case the inpatient rehab was interrupted for specific reasons
FollowUp.FURehabInPatShortTermInterrup3StartDate Third short-term rehabilitation interruption start date Only applicable in case the inpatient rehab was interrupted for specific reasons
FollowUp.FURehabNo No rehabilitation Documents that patient received no rehab at the time of this assessment.
FollowUp.FURehabOutPat Out-patient rehabilitation Documents that patient received out-patient rehab care at the time of this assessment.
FollowUp.FURehabOutPatAdmisDate Date of admission to out-patient rehabilitation Start Date of the out-patient rehab care.
FollowUp.FURehabOutPatTherpyCog Cognitive remediation therapy Reflects the type of out-patient rehab care received: Cognitive remediation
FollowUp.FURehabOutPatTherpyCogFreq Frequency of cognitive remediation as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of Cognitive remediation received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyCog".
FollowUp.FURehabOutPatTherpyCompDayTreatmnt Comprehensive day treatment as out-patient therapy Reflects the type of out-patient rehab care received: Comprehensive day treatment
FollowUp.FURehabOutPatTherpyCompDayTreatmntFreq Frequency of comprehensive day treatment as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of Comprehensive day treatment received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyCompDayTreatmnt"
FollowUp.FURehabOutPatTherpyHomeHealth Home health as out-patient therapy Reflects the type of out-patient rehab care received: Home health
FollowUp.FURehabOutPatTherpyHomeHealthFreq Frequency of home-health as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Home health' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyHomeHealth"
FollowUp.FURehabOutPatTherpyIndLivngTrainng Independent living training as out-patient therapy Reflects the type of out-patient rehab care received: Independent living training
FollowUp.FURehabOutPatTherpyIndLivngTrainngFreq Frequency of independent living training as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Independent living training' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyIndLivngTrainng"
FollowUp.FURehabOutPatTherpyNursServ Nursing services as out-patient therapy Reflects the type of out-patient rehab care received: Nursing services
FollowUp.FURehabOutPatTherpyNursServFreq Frequency of nursing services as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Nursing services' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyNursServ"
FollowUp.FURehabOutPatTherpyOcc Occupational therapy as out-patient therapy Reflects the type of out-patient rehab care received: Occupational therapy
FollowUp.FURehabOutPatTherpyOccFreq Frequency of occupational therapy as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Occupational therapy' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyOcc"
FollowUp.FURehabOutPatTherpyOther Other out-patient therapy Reflects the type of out-patient rehab care received: "Other" than the listed types Check also "FollowUp.FURehabOutPatTherpyOtherText" for the specification on the type of "other".
FollowUp.FURehabOutPatTherpyOtherFreq Frequency of other out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of "Other" therapy received as out-patient rehab care.
FollowUp.FURehabOutPatTherpyOtherText Other out-patient therapy (please specify) Specifies the type of "other" out-patient rehab care received. Check also "FollowUp.FURehabOutPatTherpyOther"
FollowUp.FURehabOutPatTherpyPeerMentor Peer mentoring as out-patient therapy Reflects the type of out-patient rehab care received: Peer mentoring
FollowUp.FURehabOutPatTherpyPeerMentorFreq Frequency of peer mentoring as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Peer mentoring' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyPeerMentor"
FollowUp.FURehabOutPatTherpyPhysicianInvolved Rehab physician involved 1 == Yes
0 == No
88 == Unknown
Reflects if a Rehab physician was involved, in case the patient received out-patient rehab care.
FollowUp.FURehabOutPatTherpyPsychSer Psychological services as out-patient therapy Reflects the type of out-patient rehab care received: Psychological services
FollowUp.FURehabOutPatTherpyPsychSerFreq Frequency of psychological services as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Psychological services' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyPsychSer"
FollowUp.FURehabOutPatTherpyPT Physical therapy as out-patient therapy Reflects the type of out-patient rehab care received: Physical therapy
FollowUp.FURehabOutPatTherpyPTFreq Frequency of physical therapy as out-patient therapy 4 == 4 - Weekly
3 == 3 - < Once a week
2 == 2 - Only follow-up, no active treatment
1 == 1 - None
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Physical therapy' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyPT"
FollowUp.FURehabOutPatTherpyRec Therapeutic recreation as out-patient therapy Reflects the type of out-patient rehab care received: Therapeutic recreaction
FollowUp.FURehabOutPatTherpyRecFreq Frequency of therapeutic recreation as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of "Therapeutic recreaction" received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyRec"
FollowUp.FURehabOutPatTherpySocWrkCaseMgmt Social work/case management as out-patient therapy Reflects the type of out-patient rehab care received: Social work/Case management
FollowUp.FURehabOutPatTherpySocWrkCaseMgmtFreq Frequency of social work/case management as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Social work/Case management' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpySocWrkCaseMgmt"
FollowUp.FURehabOutPatTherpySpeech Speech therapy as out-patient therapy Reflects the type of out-patient rehab care received: Speech therapy
FollowUp.FURehabOutPatTherpySpeechFreq Frequency of speech therapy as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of 'Speech therapy' received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpySpeech"
FollowUp.FURehabOutPatTherpyStructure Structure of out-patient therapy 1 == Mono-disciplinary (little/nocollaboration between care providers
2 == Multi-disciplinary
Reflects the structure of the out-patient rehab care received.
FollowUp.FURehabOutPatTherpyUnknown Out-patient rehab care unknown Reflects if out-patient rehab care was received but the type was "Unknown"
FollowUp.FURehabOutPatTherpyUnknownFreq Frequency of unknown out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of "Unknown" therapy received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyUnknown"
FollowUp.FURehabOutPatTherpyVocServ Vocational services as out-patient therapy Reflects the type of out-patient rehab care received: Vocational services
FollowUp.FURehabOutPatTherpyVocServFreq Frequency of vocational services as out-patient therapy 1 == 1 - None
2 == 2 - Only follow-up, no active treatment
3 == 3 - < Once a week
4 == 4 - Weekly
5 == 5 - 2-3 times/week
6 == 6 - Daily
7 == 7 - Unknown
Reflects the frequency of "Vocational services" received as out-patient rehab care. Check also "FollowUp.FURehabOutPatTherpyVocServ"
FollowUp.FURehabTBIRehabUnitInPat Type of in-patient rehabilitation unit: TBI Reflects the type of in-patient rehab care received: TBI
FollowUp.FURehabTherpyEndDate Date of discharge from out-patient rehabilitation End date of the out-patient rehab care.
FollowUp.FURehabTherpyOngoingInd Is out-patient rehab ongoing? 0 == No
1 == Yes
Reflects if the out-patient rehab care was still ongoing at the time of the follow up assessment.
FollowUp.FURehabUnknown Rehab care unknown Reflects if it was "unknown" whether rehab treatment had occurred at the time of this assessment.
FollowUp.FUResdncType Living situation/patient's residence 1 == Living at home independently
2 == Living at home supported by family/carers
11 == Living in shelteed + housing/community care
7 == Rehabilitation centre
10 == Living in nursing home
6 == Living in a long-stay patient ward(hospital)
99 == Other
Only recorded if change in SES. Reflects the Living situation/patient's residence at the time of follow up assessment, if there was a change in SES.
FollowUp.FUResdncTypeOther Other living situation/patient's residence (please specify) Only recorded if change in SES Specifies the "Other" Living situation/patient's residence at the time of follow up assessment, if there was a change in SES.
FollowUp.FURtrnToOtherAct Returned to other activities 1 == Full return to previous level
2 == Reduced level
0 == No
88 == Unknown
Prefects if at the time of follow up assessment the patient returned to other activities than work/school and at what level.
FollowUp.FURtrnWrkSchlStatus Returned to work/school 1 == Returned to previous job / school at same level and hours
8 == Returned to previous job / school at increased levels or hours from pre-injury
2 == Unable to work / go to school
9 == Returned to previous job / school at reduced level or hours
10 == Change of job / different work or school
11 == Special employment / sheltered employment
5 == Looking for work / go to school
7 == Retired
NA == N/A
88 == Unknown
Prefects if at the time of follow up assessment the patient returned to work/school and at what level.
FollowUp.FUSESChange Any change to the socio-economic status from the previous visit? 0 == No
1 == Yes
88 == Unknown
This variable aims to document any change in socio-economic status following the TBI
FollowUp.FUSESPeopleLivingWith Number of people living with Only recorded if change in SES Reflects the "Number of people living with" at the time of follow up assessment, if there was a change in SES.
FollowUp.FUSESPrimAdultAlone Persons living with: Alone Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Alone
FollowUp.FUSESPrimAdultCarerUnrelated Persons living with: Carers unrelated to patient Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Carers unrelated to patient
FollowUp.FUSESPrimAdultChildren Persons living with: Child/children Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Child/children
FollowUp.FUSESPrimAdultOther Persons living with: Other (incl) correctional facility inmates) Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Other (incl. correctional facility inmates)
FollowUp.FUSESPrimAdultParents Persons living with: Parents Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Parents
FollowUp.FUSESPrimAdultSiblings Persons living with: Siblings Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Siblings
FollowUp.FUSESPrimAdultSignOther Persons living with: Significant other partner Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Significant other partner
FollowUp.FUSESPrimAdultSpousePartner Persons living with: Spouse (including common law partner) Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Spouse (including common law partner)
FollowUp.FUSESPrimAdultUnknown Change in Socio-economic Status unknown Only recorded if change in SES Reflects the "Persons living with" at the time of follow up assessment, if there was a change in SES: Unknown
FollowUp.FUSurgCranioplastyPerformed Cranioplasty performed 1 == Yes
2 == No, but scheduled
0 == No
On Follow-up assessment, general information is captured on Medical and Surgical Therapies. This reflects if Cranioplasty was performed. Only applicable in case a decompressive craniectomy was performed during the in-hospital period
FollowUp.FUSurgExtracranialSurg Extracranial surgery 88 == Unknown
0 == No
1 == Yes
On Follow-up assessment, general information is captured on Medical and Surgical Therapies. This variable aims to capture any form of extracranial surgery performed after discharge
FollowUp.FUSurgExtracranialSurgDate Date of extracranial surgery On Follow-up assessment, general information is captured on Medical and Surgical Therapies. This variable reflects the date, in case any form of extracranial surgery was performed.
FollowUp.FUSurgExtracranialSurgSpecify Type of extracranial surgery (please specify) On Follow-up assessment, general information is captured on Medical and Surgical Therapies. This variable specifies the type, in case any form of extracranial surgery was performed.
FollowUp.FUSurgExtracranialSurgTime Time of extracranial surgery On Follow-up assessment, general information is captured on Medical and Surgical Therapies. This variable reflects the date, in case any form of extracranial surgery was performed.
FollowUp.FUVisitDate Date of follow-up assessment Date of follow up visit
FollowUp.FUVisitTime Time of follow-up assessment Time of follow up visit. Check also "FollowUp.FUVisitDate" for the date.
FollowUp.FUVisitType Follow up visit type (scheduled or unscheduled) UNSCHED == Unscheduled follow-up
SCHED == Scheduled study follow-up
All Follow-up assessments used questionnaire assessments, and at selected pre-specified time points, neuropsychological testing was done during out-patient follow-up. The schedule for assessments was differentiated by stratum. Cross-sectional assessments, including questionnaires and neuropsych, was performed at 6 mnths post injury. Further Questionnaire assessments were schduled as follows: ER stratum: 2-3 weeks and 3 months; Adm stratum: 3 mnths and 12 mnths; ICU stratum: 3 months and 12 months.
FollowUp.FUVitStatus Is the patient dead or alive? 0 == Dead
1 == Alive
88 == Unknown
This variable reflects the status of the patient at the time of a scheduled follow up visit. The status could be Dead, Alive, Unknown
FollowUp.IcometrixImageId Icometrix image ID for follow up imaging Identifier generated for an imaging experiment when images are uploaded from site It's recommended to use: Imaging.CRFIcometrixImageId
FollowUp.IcometrixPassedQA Follow up images passed QA of icometrix 1 == Yes
0 == No
Reflects if images uploaded from site passed QA of icometix. It's recommended to use: Imaging.CRFIcometrixPassedQA
FollowUp.IcometrixQADateTime Date and time of QA icometrix for follow up images Date and time when central QA was done for followup images It's recommended to use: Imaging.CRFIcometrixQADateTime
FollowUp.IcometrixUploadDateTime Date and time of upload to icometrix for follow up images Date/Time of image upload to Icometrix
FollowUp.InitialDataIcometrix Imaging data in CRF loaded from icometrix (not by study nurse) Reflects if the imaging data was not entered by the site in the e-CRF but directly from the images at icometrix (if not, it means the data in the e-CRF was entered manually by the study nurse) It's recommended to use "Imaging.CRFInitialDataIcometrix"
FollowUp.MRIManuf MRI scan manufacturer for follow up MRI 99 == Other
TOSH == Toshiba
GE == GE
PHIL == Philips
SIEM == Siemens
This variable reflects the manufacturer of the follow up MRI scanner used. It's recommended to use "Imaging.CRFMRIManuf"
FollowUp.MRIReason Reason of MRI for follow up MRI SP == Study protocol
88 == Unknown
99 == Other
CD == Clinical deterioration
LOP == Lack of improvement
SBL == Suspicious brainstem lesions
ISC == Ischemia
CR == Clinical routine
This variable contains the main reason why an MRI at follow up was performed. It's recommended to use Imaging.CRFMRIReason
FollowUp.MRIReasonOther Other Reason of MRI for follow up MRI Specifies the type of "other" reason for MRI at follow up It's recommended to use Imaging.CRFMRIReasonOther
FollowUp.MRIResultPreExistAbnorm Pre-existing abnormalities on follow up MRI 88 == Unknown
0 == No
1 == Yes
Scored by investigator Reflects if there are pre-existing abnormalities on the follow up MRI. It’s recommended to use Imaging.CRFMRIResultPreExistAbnorm
FollowUp.MRIResultTraumaticAbnorm Traumatic abnormalities on follow up MRI 88 == Unknown
1 == Yes
0 == No
Scored by investigator Reflects if there are Traumatic abnormalities on the follow up MRI. It’s recommended to use Imaging.CRFMRIResultTraumaticAbnorm
FollowUp.MRIScannerStrength MRI scanner strength for follow up MRI This variable describes the follow up MRI scanner strength. This is a text field. It’s recommended to use Imaging.CRFMRIScannerStrength
FollowUp.MRISequences MRI sequences for follow MRI 99 == Other
PWI == PWI
MRSI == MRSI
SWI == SWI
DTI == DTI
GRE == GRE
FLAIR == FLAIR
DWI == DWI
T2 == T2
T1 == T1
This variable describes the follow up MRI sequence. Options are: T1, T2, FLAIR, DWI, GRE, SWI, DTI, MRSI, PWI, Other. Multiple options can be selected. It’s recommended to use Imaging.CRFMRISequences
FollowUp.MRITraumAbnormASDH ASDH present on follow up MRI 88 == Unknown
1 == Yes
0 == No
This variable describes whether or not there is an acute subdural hematoma present on follow up MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormASDH
FollowUp.MRITraumAbnormContusion Contusion present on follow up MRI 88 == Unknown
1 == Yes
0 == No
This variable describes whether or not there is a contusion present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormContusion
FollowUp.MRITraumAbnormDAI DAI present on follow up MRI 0 == No
1 == Yes
88 == Unknown
This variable describes whether or not there is DAI (diffuse axonal injury) present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAI
FollowUp.MRITraumAbnormDAILesionLocBrainstem Brain stem lesion present on follow up MRI 1 == Yes
88 == Unknown
0 == No
This variable describes whether or not there is a brain stem lesion present on follow up MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAILesionLocBrainstem
FollowUp.MRITraumAbnormDAILesionLocCorpusCallosum Corpus callosum lesion present on follow up MRI 88 == Unknown
0 == No
1 == Yes
This variable describes whether or not there is a corpus callosum lesion present on follow up MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAILesionLocCorpusCallosum
FollowUp.MRITraumAbnormDAILesionLocDiffuseWhiteMatter Lesion in diffuse white matter present on follow up MRI 88 == Unknown
1 == Yes
0 == No
This variable describes whether or not there is a lesion in diffuse white matter present on follow up MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAILesionLocDiffuseWhiteMatter
FollowUp.MRITraumAbnormDAINumLesions Number of DAI lesions present on follow up MRI 1 == 1
2 == 2
3 == 3
4 == 4
5 == >= 5
This variable describes how many DAI lesions are present on follow up MRI scan (1,2,3,4,>=5). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormDAINumLesions
FollowUp.MRITraumAbnormEDH Epidural hematoma present on follow up MRI 1 == Yes
88 == Unknown
0 == No
This variable describes whether or not there is an epidural hematoma present on follow up MRI scan (yes, no, unknown). Assessment by investigator and/or physician. It’s recommended to use Imaging.CRFMRITraumAbnormEDH
FollowUp.MRIType Type of MRI done (MRI, MRA) for follow up MRI MRA == MRA
MRI == MRI
This variable describes the type of follow up MRI scan that has been made. Options are: MRI, MRA It’s recommended to use Imaging.CRFMRIType
FollowUp.TimePoint Follow-up assessment timepoint 3mo == 3 months
2wk == 2 weeks
6mo == 6 months
12mo == 12 months
24mo == 24 months
Follow up timepoints are 2-3 weeks, 3 months, 6 months, 12 months and 24 months. Depending on the stratum and sub-studies of a patient, follow up was performed at some of these time points or at all timepoints. For an overview, please check the SOP Manual.
Genetics.CollectionDate Collection time of the Genetic sample Collection Date and Time of the Genetic sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Genetics.CollectionTime Collection date of the Genetic sample Collection Date and Time of the Genetic sample. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Genetics.FreezerMinusEightyDate Date the Genetic sample was stored in a -80 freezer The 4.9ml whole blood sample for genetic assays should be stored at -80°C with a needle to freezer time preferably within 6 hours. This variable reflects the date and time that the sample was stored in a minus 80 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Genetics.FreezerMinusEightyTime Time the Genetic sample was stored in a -80 freezer The 4.9ml whole blood sample for genetic assays should be stored at -80°C with a needle to freezer time preferably within 6 hours. This variable reflects the date and time that the sample was stored in a minus 80 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Genetics.FreezerMinusTwentyDate Date the Genetic sample was stored in a -20 freezer The 4.9ml whole blood sample for genetic assays should be stored at -80°C with a needle to freezer time preferably within 6 hours. However, if a -80°C freezer was not immediately accessible, samples could be temporarely (max 48 hours) stored in a minus 20°C non-frost-free freezer. This variable reflects the date and time that the sample was stored in a minus 20 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Genetics.FreezerMinusTwentyTime Time the Genetic sample was stored in a -20 freezer The 4.9ml whole blood sample for genetic assays should be stored at -80°C with a needle to freezer time preferably within 6 hours. However, if a -80°C freezer was not immediately accessible, samples could be temporarely (max 48 hours) stored in a minus 20°C non-frost-free freezer. This variable reflects the date and time that the sample was stored in a minus 20 freezer. These date/time values were provided by the sites on the “sample collection and processing forms” enclosed to the samples.
Genetics.SampleId Sample identifier for the Genetic sample Per patient 1x 4.9 ml blood samples was collected into 1x 4.9 ml potassium EDTA tubes for genetic assays.
Hospital.AdditionalStudiesCoag Are coagulation studies performed? 0 == No
1 == Yes
Intended to provide documentation if the patient was enrolled in the Coagulation sub-study or not.
Hospital.AdditionalStudiesECoG Is Electrocorticography (ECoG) performed? 0 == No
1 == Yes
Intended to provide documentation if the patient was enrolled in the ECoG sub-study or not.
Hospital.AdditionalStudiesEEG Is continuous EEG performed? 0 == No
1 == Yes
Intended to provide documentation if the patient was enrolled in the EEG sub-study or not.
Hospital.AdditionalStudiesTEGRotem Are TEG/ROTEM studies performed? 0 == No
1 == Yes
Intended to provide documentation if the patient was enrolled in the TEG/ROTEM sub-study or not.
Hospital.BrainDeathDate Date of brain death Reflects the date of Brain death in case of Withdrawal of life-sustaining measures
Hospital.BrainDeathTime Time of brain death Reflects the Time of Brain death in case of Withdrawal of life-sustaining measures Check also "Hospital.BrainDeathDate" for the date.
Hospital.ComplCRBSIDateDiagnosis Date of diagnosis of Catheter Related Bloodstream Infection (CRBSI) at ICU discharge At discharge, complications and adverse events were summarized. This variable reflects the date of diagnosis of CRBSI in case of systemic complication.
Hospital.DeadAge Withdraw of life sustaining measures: For reason of age 0 == No
1 == Yes
88 == Unknown
Reflects if the reason for Withdrawal of life-sustaining measures was age.
Hospital.DeadCoMorbidities Withdraw of life sustaining measures: For reason of co-morbidities 0 == No
1 == Yes
88 == Unknown
Reflects if the reason for Withdrawal of life-sustaining measures was co-morbidities.
Hospital.DeadDeterminationOfBrainDeath Withdraw of life sustaining measures: Determination of brain death (according to national law) 0 == No
1 == Yes
88 == Unknown
Reflects if the reason for Withdrawal of life-sustaining measures was Determination of brain death (according to national law).
Hospital.DeadOrganDonation Is determination of brain death followed by organ donation? 0 == No
1 == Yes
88 == Unknown
Reflects if Withdrawal of life-sustaining measures was followed by organ donation.
Hospital.DeadPatWill Withdraw of life sustaining measures: Following living will of patient 0 == No
1 == Yes
88 == Unknown
Reflects if the reason for Withdrawal of life-sustaining measures was Following living will of patient.
Hospital.DeadRequestRelatives Withdraw of life sustaining measures: On request of relatives 0 == No
1 == Yes
88 == Unknown
Reflects if the reason for Withdrawal of life-sustaining measures was On request of relatives.
Hospital.DeadSeverityofTBI Withdraw of life sustaining measures: For severity of TBI 0 == No
1 == Yes
88 == Unknown
Reflects if the reason for Withdrawal of life-sustaining measures was Severity of TBI.
Hospital.DeathAutopsy Was autopsy performed? 0 == No
1 == Yes, forensic
2 == Yes, clinical
88 == Unknown
Reflects if an autopsy was performed after the death of the patient.
Hospital.DeathCause Principal cause of death 4 == Medical complications
3 == Systemic trauma
2 == Head injury/secondary intracranial damage
1 == Head injury/initial injury
99 == Other
Reflects the principal cause of death of a patient in-hospital.
Hospital.DeathCauseOther Other principal cause of death (please specify) Reflects if the cause of in-hospital death was "other" than the listed causes.
Hospital.DischargeStatus Is patient alive or dead at ward discharge? 1 == Alive
0 == Dead
88 == Unknown
Assessment by investigator Reflects if the patient was dead or alive at discharge.
Hospital.DispHosp Destination from Hospital 3 == Nursing home
2 == Rehab unit
1 == Other hospital
99 == Other
5 == Home
88 == Unknown
Documents destination upon hospital discharge
Hospital.DispHospOther Other destination from Hospital (please specify) Specifies if the reason for hospital discharge was "other" than the listed discharge reasons.
Hospital.GCSHospDischargeEyes Eye opening (E) response at Hospital discharge O == Untestable (other)
4 == 4-Spontaneously
S == Untestable (swollen)
2 == 2-To pain
1 == 1-None
3 == 3-To speech
UN == Unknown
Eye opening score for GCS at hospital discharge.
Hospital.GCSHospDischargeMotor Motor (M) response at Hospital discharge P == Untestable (Deep sedation/paralyzed)
6 == 6-Obeys command
4 == 4-Normal flexion/withdrawal
5 == 5-Localizes to pain
3 == 3-Abnormal flexion
2 == 2-Abnormal extension
1 == 1-None
O == Untestable (Other)
UN == Unknown
Motor score for GCS at hospital discharge.
Hospital.GCSHospDischargeScore GCS score at Hospital discharge GCS score at hospital discharge.
Hospital.GCSHospDischargeVerbal Verbal (V) response at Hospital discharge O == Untestable (Other)
T == Untestable (tracheotomy/endotracheal tube)
5 == 5-Oriented
4 == 4-Confused
1 == 1-None
3 == 3-Inappropriate words
2 == 2-Incomprehensible sound
UN == Unknown
Verbal score for GCS at hospital discharge.
Hospital.HospComplCardio Cardiovascular complication at Hospital discharge 1 == Yes
0 == No
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Cardiovascular as systemic complications.
Hospital.HospComplCRBSI Catheter Related Bloodstream Infection (CRBSI) at Hospital discharge 0 == No
1 == Yes
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of CRBSI (catheter related blood stream infection) as systemic complications.
Hospital.HospComplDelayedHaema Delayed haematoma at Hospital discharge 1 == Yes
0 == No
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Delayed haematoma as Intracranial complications (requiring treatment).
Hospital.HospComplDVT Deep Vein Thrombosis (DVT) at Hospital discharge 1 == Yes
0 == No
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of DVT (deep venous thrombosis) as systemic complications.
Hospital.HospComplIntraCranOther Other Intracranial complication at Hospital discharge 0 == No
1 == Yes
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of "Other" Intracranial complications (requiring treatment) than listed.
Hospital.HospComplIntraCranOtherTxt Other Intracranial complication at Hospital discharge (please specify) At discharge, complications and adverse events were summarized. This variable reflects the type of "Other" Intracranial complications (requiring treatment).
Hospital.HospComplMeningitis Meningitis/Ventriculitis at Hospital discharge 1 == Yes
0 == No
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Meningitis/Ventriculitis as Intracranial complications (requiring treatment).
Hospital.HospComplMetabolic Metabolic complication at Hospital discharge 0 == No
1 == Yes
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Metabolic as systemic complications.
Hospital.HospComplPressureSore Pressures sores (decubitus) at Hospital discharge 0 == No
1 == Yes
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Pressures sores (decubitus) as systemic complications.
Hospital.HospComplPumlEmb Pulmonary embolus at Hospital discharge 1 == Yes
0 == No
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Pulmonary embolus as systemic complications.
Hospital.HospComplRasiedICP Raised/increased ICP at Hospital discharge 0 == No
1 == Yes
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Raised ICP as Intracranial complications (requiring treatment).
Hospital.HospComplResp Respiratory complication at Hospital discharge 1 == Yes
0 == No
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Respiratory as systemic complications.
Hospital.HospComplSeizures Seizures at Hospital discharge 1 == Yes
0 == No
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Seizures as Intracranial complications (requiring treatment).
Hospital.HospComplSystemOther Other Systemic complication at Hospital discharge 0 == No
1 == Yes
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of "Other" systemic complications than listed.
Hospital.HospComplSystemOtherTxt Other Systemic complication at Hospital discharge (please specify) At discharge, complications and adverse events were summarized. This variable reflects the type of "Other" systemic complications.
Hospital.HospComplUTI Urinary tract infection at Hospital discharge 1 == Yes
0 == No
At discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Urinary tract infection as systemic complications.
Hospital.HospDischargeBodyWeightkg Body weight reported at Hospital discharge Body weight on discharge in Kgs
Hospital.HospDischargeBodyWeightlbs Body weight on discharge in Lbs Body weight on discharge in Lbs
Hospital.HospDischargeBodyWeightMeasure Reliability of body weight reported at Hospital discharge 1 == Estimated
2 == Measured
Reflects if Body weight was measured at discharge
Hospital.HospDischargeBodyWeightUnit Unit used for body weight at discharge (kg or lbs) 1 == kgs
2 == lbs
Reflects the unit used for body weight at discharge (kgs or lbs).
Hospital.HospDischargeCTProgression CT progression 0 == No
1 == Yes
Pre-defined early endpoints recorded at ICU or hospital discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, number of CTs performed and CT progression.
Hospital.HospDischargeCTProgressionYes CT progression (please specify) 1 == Increase in initial lesion
2 == Development of new lesion
Pre-defined early endpoints recorded at ICU discharge or hospital discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, number of CTs performed and CT progression. If CT progression was "yes", this reflects if there was Increase in initial lesion or Development of new lesion.
Hospital.HospDischargeNumberCT Number of CT's performed 0 == No
1 == Yes
Pre-defined early endpoints recorded at ICU or hospital discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, number of CTs performed and CT progression.
Hospital.HospDischargeReason Reason for Hospital discharge 0 == No institutional care necessary
3 == Waiting list for rehab
2 == Clinical rehab required but not approved
1 == No institutional care in trauma center necessary
99 == Other
4 == Clinical rehab required and approved
5 == No benefit of clinical rehab anticipated
WHY question: documents reason for choice of (hospital) discharge destination.
Hospital.HospDischargeReasonOther Other reason for Hospital discharge (please specify) Specifies if the reason for (hospital) discharge destination was "other".
Hospital.HospDischargeTimeToObeyCommands Time to obey commands Pre-defined early endpoints recorded at ICU or hospital discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, number of CTs performed and CT progression.
Hospital.HospDischargeTimeToObeyCommandsNotApplic No improvement in obeying commands at discharge Intended for use in patients who did not improve to obeying commands at the time of discharge. However, some sites may have used this to mark also patients who never had a depression of consciousness, to the extend that they did not obey commands.
Hospital.HospDischDate Date of Hospital discharge Hospital discharge:this variable was included also in the ICU form, in particular to record discharge dates for patients discharged directly from the ICU either dead or alive.
Hospital.HospDischPTADays PTA on discharge This variable aims to facilitate collection of more information on PTA for subjects who were still in PTA at the time of admission to hospital. For study-broad interpretation of PTA,, the PTA as recorded on discharge from ER should also be taken into consideration: InjuryHx.LOCPTADuration
Hospital.HospDischPTADaysNA Patient had no PTA or did not recover from PTA at discharge This variable could have been interpreted as either patients never having had PTA or alternatively, a patient who did not recover out of PTA by the time of discharge.
Hospital.HospDischPTAOngoing PTA ongoing at hospital discharge Intended to designate patients who are still in PTA at the moment of discharge of hospital
Hospital.HospDischTime Time of Hospital discharge Hospital discharge:this variable was included also in the ICU form, in particular to record discharge dates for patients discharged directly from the ICU either dead or alive.
Hospital.HospNeuroworseEpisode Any episode of Neuroworsening until Hospital discharge 0 == No
1 == Yes
Pre-defined early endpoints recorded at ICU or hospital discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, number of CTs performed and CT progression.
Hospital.ICDCode1 (1) ICD code at Hospital discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode10 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode11 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode12 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode13 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode14 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode15 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode16 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode2 (2) ICD code at Hospital discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode3 (3) ICD code at Hospital discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode4 (4) ICD code at Hospital discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode5 (5) ICD code at Hospital discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode6 (6) ICD code at Hospital discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode7 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode8 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCode9 Up to 16 fields to enter ICD codes (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients admitted/discharged from hospital. For patients discharged directly from the ER, ICD codes are documented in: InjuryHx.ERDestICDCodes1
Hospital.ICDCodeVersion Version of ICD code used at Hospital discharge 9 == ICD-9
10 == ICD-10
This variable reflects if the ICD code version 9 or version 10 was used. Up to 16 fields are available to enter diagnosis as recorded by hospital administration according to ICD codes.
Hospital.ICPDevice Type of ICP monitor 1 == Ventricular
2 == Ventricular +inbuilt sensor
3 == Parenchymal
99 == Other
Type of ICP monitoring device used.
Hospital.ICPDeviceOther Other type of ICP monitor (please specify) Free text field with description of which ICP monitoring device was used, in case the device was not listed in the pre-specified list of the CRF. Some patients have had more than one ICP monitoring device, which are listed here.
Hospital.ICPInsDate Date ICP monitoring started Start date of ICP monitoring.
Hospital.ICPInsTime Time ICP monitoring started Start time of ICP monitoring Check also "Hospital.ICPInsDate" for the start date.
Hospital.ICPMonitorNo ICP not monitored Indicates if a patient does not have intracranial pressure (ICP) monitoring. If Hospital.ICPMonitorNo=1, see Hospital.ICUReasonNoICP.
Hospital.ICPMonitorStop ICP monitoring stopped 1 == Yes
0 == No
If ICP monitoring has stopped or not. Time and date is found in Hospital.ICPRemTime and Hospital.ICPRemDate. Reason for stopping ICP monitoring is found in Hospital.ICPStopReason.
Hospital.ICPMonitorStopReasonOther Other reason for stopping ICP monitoring (please specify) Specifies the "other" reason if the reason for stopping ICP was not on the pre-defined list. Check also "Hospital.ICPStopReason"
Hospital.ICPMonitorYes ICP monitored 0 == No
1 == Yes
Indicates if a patient has intracranial pressure (ICP) monitoring. If yes, see Hospital.ICUReasonICP and Hospital.ICPDevice.
Hospital.ICPMontDuration Duration of ICP monitoring The duration of ICP monitoring. Calculated variable: Hospital.ICPRemDateTime-Hospital.ICPInsDateTime.
Hospital.ICPRemDate Date ICP monitoring stopped Date for stopping ICP monitoring.
Hospital.ICPRemTime Time ICP monitoring stopped Time of stopping ICP monitoring.
Hospital.ICPStopReason Reason for stopping ICP monitoring 1 == Clinically improved
2 == ICP stable and < 20 mmHg
3 == Monitor/catheter failure
4 == Patient considered unsalvagable
5 == Patient died
99 == Other
Reason for stopping ICP. Also check Hospital.ICPMonitorStop.
Hospital.ICPUnit Origin of patient when transfered to ICU 1 == ER
2 == OR
3 == Ward
4 == High dependency unit
99 == Other hospital
The type of department the patient was transferred from to the ICU.
Hospital.ICUAdmDate Date of admission to ICU Date of Admission to the ICU. In principle the date of injury; date of enrollment and Date of Admission to ICU will match, but in some cases there can be a difference of 1 or 2 days. For example when a patient was injured late at night, it is possible that the consent was only obtained in the morning, hence the date of Study Enrollment will be 1 day later than the date of injury. Or in some hospitals a patient is kept for 24 hours in observation at the ER in a specific unit before being transferred to ICU or Ward. Hence the Date of Admission to ICU or Ward can be 1 or 2 days later. Or if there is no bed available on ICU or Ward for a patient being injured late at night, there can be a delay in admitting the patient.
Hospital.ICUAdmisStatusHaemoStable Was patient Haemodynamically stable at ICU arrival? 0 == No
1 == Yes
88 == Unknown
Reflects the status of the patient on admission to the ICU: Haemodynamically stable
Hospital.ICUAdmisStatusIntubated Was patient intubated at ICU arrival? 0 == No
1 == Yes
88 == Unknown
Reflects the status of the patient on admission to the ICU: Intubated
Hospital.ICUAdmisStatusMechVent Was patient mechanically ventilated at ICU arrival? 0 == No
1 == Yes
88 == Unknown
Reflects the status of the patient on admission to the ICU: Mechanically ventilated
Hospital.ICUAdmReason Reason for admission to ICU 6 == Clinical deterioration
5 == Neurological operation
4 == Extracranial injuries
3 == Haemodynamic invasive monitoring
2 == Frequent neurological observations
1 == Mechanical ventilation
99 == Other
Main reason for admission to ICU
Hospital.ICUAdmReasonOther Other reason for admission to ICU Specifies the "other" if the main reason for admission to the ICU was other than the pre-defined list.
Hospital.ICUAdmTime Time of admission to ICU Time of admission to the ICU. Check also "Hospital.ICUAdmDate" for the date of admission.
Hospital.ICUCardiacOutput Cardiac output 0 == No
1 == Yes
Reflects the type, in case of systemic monitoring on ICU: Cardiac output
Hospital.ICUCatheterICP ICP catheter revised 0 == No
1 == Yes
Reflects if the ICP catheter has been revised in case of ICP monitoring
Hospital.ICUCatheterICPDate Date of revision of ICP catheter Reflects the date on which ICP catheter has been revised in case of ICP monitoring Check also "Hospital.ICUCatheterICP"
Hospital.ICUCatheterICPTime Time of revision of ICP catheter Reflects the time on which ICP catheter has been revised in case of ICP monitoring Check also "Hospital.ICUCatheterICP" and "Hospital.ICUCatheterICPDate"
Hospital.ICUCentralVenousPress Central venous pressure 0 == No
1 == Yes
Reflects the type, in case of systemic monitoring on ICU: Central venous pressure
Hospital.ICUComplUTI Urinary tract infection (UTI) at ICU discharge 0 == No
1 == Yes
At discharge, complications and adverse events were summarized. This variable reflects the date of diagnosis of Urinary tract infection in case of systemic complication.
Hospital.ICUDisAdditionalStudiesCoag Are coagulation studies performed? 0 == No
1 == Yes
Intended to provide documentation if the patient was enrolled in the Coagulation sub-study or not.
Hospital.ICUDisAdditionalStudiesTEGRotem Are TEG/ROTEM studies performed? 0 == No
1 == Yes
Intended to provide documentation if the patient was enrolled in the TEG/ROTEM sub-study or not.
Hospital.ICUDischargeICDCode1 (1) ICD code at ICU discharge The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode10 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode11 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode12 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode13 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode14 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode15 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode16 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode2 (2) ICD code at ICU discharge The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode3 (3) ICD code at ICU discharge The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode4 (4) ICD code at ICU discharge The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode5 (5) ICD code at ICU discharge The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode6 (6) ICD code at ICU discharge The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode7 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode8 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCode9 Up to 16 fields to enter ICD codes at ICU discharge (of hospital administration) The intent here is to register ICD code as recorded in hospital administrative files for patients directly discharged from the ICU. Up to 16 codes can be entered, ICD codes are further captured at ER discharge and at hospital discharge.
Hospital.ICUDischargeICDCodeVersion Version of ICD code used at ICU discharge 9 == 9
10 == 10
This variable reflects if the ICD code version 9 or version 10 was used. Up to 16 fields are available to enter diagnosis as recorded by hospital administration according to ICD codes.
Hospital.ICUDischargeStatus Is the patient alive or dead at ICU discharge? 1 == Alive
2 == Dead
88 == Unknown
Reflects if patient was alive or dead on discharge from ICU
Hospital.ICUDischargeTo Destination from ICU discharge 1 == General ward
2 == Other ICU
3 == Other hospital
4 == Rehab unit
5 == Home
6 == Nursing home
7 == Step down/high care unit
99 == Other
88 == Unknown
Reflects location to which the patient was discharged from ICU
Hospital.ICUDischargeToOther Other destination from ICU discharge (please specify) Specifies the "other" location to which the patient was discharged from ICU Check also "Hospital.ICUDischargeTo"
Hospital.ICUDischDate Date of ICU discharge Reflects the ICU Discharge Date
Hospital.ICUDischPTADays PTA on discharge Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression.
Hospital.ICUDischPTADaysNA PTA on discharge Not applicable Reflects if PTA was not applicable. Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression.
Hospital.ICUDischPTAOngoing PTA ongoing at ICU discharge Reflects of PTA was ongoing on ICU discharge. Pre-defined early endpoints recorded at ICU or hospital discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, number of CTs performed and CT progression.
Hospital.ICUDischTime Time of ICU discharge ICU Discharge Time Check also "Hospital.ICUDischDate" for the ICU discharge Date
Hospital.ICUDisComplCardiacArrest Cardiovascular complication at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Cardiovascular systemic complication.
Hospital.ICUDisComplCRBSI Catheter Related Bloodstream Infection (CRBSI) 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of CRBSI (catheter-related bloodstream infection) as systemic complication.
Hospital.ICUDisComplDVT Deep Vein Thrombosis (DVT) at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of DVT (Deep venous thrombosis) as systemic complication.
Hospital.ICUDisComplIntraCranOther Other intracranial complication at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of "Other" Intracranial complication (requiring treatment).
Hospital.ICUDisComplIntraCranOtherTxt Other Intracranial complication at ICU discharge (please specify) At ICU discharge, complications and adverse events were summarized. This variable specifies the type of "Other" Intracranial complication (requiring treatment).
Hospital.ICUDisComplMeningitis Meningitis/Ventriculitis at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of "Meningitis/Ventriculitis" as Intracranial complication (requiring treatment).
Hospital.ICUDisComplMetabolic Metabolic complication at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Metabolic systemic complication.
Hospital.ICUDisComplPE Pulmonary embolus at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Pulmonary embolus as systemic complication.
Hospital.ICUDisComplPressureSores Pressures sores (decubitus) at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Pressures sores (decubitus) as systemic complication.
Hospital.ICUDisComplRaisedICP Raised or increased ICP at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of "Raised ICP" as Intracranial complication (requiring treatment).
Hospital.ICUDisComplRespiratoryFailure Respiratory complication at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of Respiratory systemic complication.
Hospital.ICUDisComplSeizure Seizures at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of "Seizures" Intracranial complication (requiring treatment).
Hospital.ICUDisComplSeromaHematoma Delayed haematoma at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of "Delayed haematoma" Intracranial complication (requiring treatment).
Hospital.ICUDisComplSystemOther Other systemic complication at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of "Other" systemic complication.
Hospital.ICUDisComplSystemOtherTxt Other systemic complication at ICU discharge (please specify) At ICU discharge, complications and adverse events were summarized. This variable specifies the type of "Other" systemic complication.
Hospital.ICUDisComplVAP Ventilator Associated Pneumonia (VAP) at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. This variable reflects the presence or absence of VAP (Ventilator associated pneumonia) as systemic complication.
Hospital.ICUDisCTProg CT progression 0 == No
1 == Yes
Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression.
Hospital.ICUDisCTProgYes CT progression (please specify) 1 == Increase in initial lesion
2 == Development of new lesion
Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression. If CT progression was "yes", this reflects if there was Increase in initial lesion or Development of new lesion.
Hospital.ICUDishDurVent Duration ventilation Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression.
Hospital.ICUDishDurVentNA Duration of ventilation on discharge Not applicable Reflects if Duration of ventilation was not applicable. Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression.
Hospital.ICUDisNeuroworseEpisode Any episode of Neuroworsening until ICU dischage 0 == No
1 == Yes
Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression.
Hospital.ICUDisNososcomialPneumNum Nosocomial pneumonia number At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This variable reflects the Nosocomial pneumonia number.
Hospital.ICUDisNumCT Number of CT's performed Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression.
Hospital.ICUDisPatDeadAtICU Has patient died in the ICU? 0 == No
1 == Yes
Reflects if the patient was declared dead on the ICU. Intended as an introductory question for the details on withdrawal of treatment, brain death and organ donation
Hospital.ICUDisPneumAntibiotic1StartDate Date of the beginning of first Antibiotic treatment At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the start date of antibiotic treatment if given.
Hospital.ICUDisPneumAntibiotic2StartDate Date of the beginning second Antibiotic treatment At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the start date of antibiotic treatment if given.
Hospital.ICUDisPneumAntibiotic3StartDate Date of the beginning third Antibiotic treatment At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the start date of antibiotic treatment if given.
Hospital.ICUDisPneumAntibiotic4StartDate Date of the beginning fourth Antibiotic treatment At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the start date of antibiotic treatment if given.
Hospital.ICUDisPneumAntibioticTreat Antibiotic treatment started at ICU discharge 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the antibiotic treatment was given for VAP.
Hospital.ICUDisPneumBacteriaSmpl Bacteriological sample 1 == BAL
2 == Tracheal suction
3 == PDP
4 == Brush
At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the type of Bacteriological sample taken.
Hospital.ICUDisPneumBloodFiO2pc FiO2 at ICU discharge At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects the details of blood gas.
Hospital.ICUDisPneumBloodPaCO2mmHg PaCO2 at ICU discharge At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the details on blood gas.
Hospital.ICUDisPneumBloodPaO2mmHg PaO2 at ICU discharge At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the details on blood gas.
Hospital.ICUDisPneumBloodPEPcmH2O Positive End-Expiratory Pressure (PEEP) at ICU discharge At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the details on blood gas.
Hospital.ICUDisPneumBloodPF PaO2/FiO2 at ICU discharge At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects if the details on blood gas.
Hospital.ICUDisPneumChestX Chest X-ray 1 == New pneumonia
2 == Modification of an old one
3 == No infiltrate
4 == Diffuse (or patchy) infiltrate
5 == Localized infiltrate
At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects the details on the Chest X-ray.
Hospital.ICUDisPneumClinical Clinical 1 == Fever >=38degC or hypothermia <=36degC
2 == Purulent trachea aspirations
3 == Leukocytes >=12000/ml or <=4000/ml
At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects the clinical details on VAP.
Hospital.ICUDisPneumDate Date of occurrence of Ventilator Associated Pneumonia (VAP) At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects the date of occurrence of the VAP.
Hospital.ICUDisPneumPathogen1 (1) Name of pathogen At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects details on the responsible pathogens for the VAP.
Hospital.ICUDisPneumPathogen1QuantUCFml (1) Quantity of pathogen At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects details on the responsible pathogens for the VAP.
Hospital.ICUDisPneumPathogen2 (2) Name of pathogen At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects details on the responsible pathogens for the VAP.
Hospital.ICUDisPneumPathogen2QuantUCFml (2) Quantity of pathogen At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects details on the responsible pathogens for the VAP.
Hospital.ICUDisPneumPathogen3 (3) Name of pathogen At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects details on the responsible pathogens for the VAP.
Hospital.ICUDisPneumPathogen3QuantUCFml (3) Quantity of pathogen At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects details on the responsible pathogens for the VAP.
Hospital.ICUDisPneumPathogen4 (4) Name of pathogen At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects details on the responsible pathogens for the VAP.
Hospital.ICUDisPneumPathogen4QuantUCFml (4) Quantity of pathogen At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes, details on the VAP were recorded. This reflects details on the responsible pathogens for the VAP.
Hospital.ICUDisPneumSepsis Sepsis or septic shock associated 0 == No
1 == Yes
At ICU discharge, complications and adverse events were summarized. Presence or absence of VAP (Ventilator associated pneumonia) as systemic complication was recorded. In case presence of VAP was "yes", details on the VAP were recorded. This reflects details on the sepsis or if septic chock associated.
Hospital.ICUDisSixMonthOutcomeDate Date of prognostic estimate of 6 month outcome At ICU discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ICU". This reflects the date of the prognostic estimate.
Hospital.ICUDisSixMonthOutcomeGOS Expected GOS (Glasgow Outcome Scale) at 6 months D == Death
V == Vegetative state
SD == Severe Disability
MD == Moderate Disability
GR == Good Recovery
At ICU discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ICU". This reflects the Expected outcome (GOS).
Hospital.ICUDisSixMonthOutcomeQualification Qualification of the physician estimating the six month outcome 1 == Resident
2 == Junior staff (< 5 years)
3 == Senior staff ( >5 years)
4 == Head of department
At ICU discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ICU". This reflects the qualification of the physician who provided prognostic estimate on discharge from ICU
Hospital.ICUDisSixMonthOutcomeType Type of the physician estimating the six month outcome 99 == Other
1 == ER physician
2 == Intensive care physician
3 == Neurology
4 == Neurosurgery
5 == Traumatology
88 == Unknown
At ICU discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ICU". The reflects the specialty of the physician who provided prognostic estimate on discharge from ICU
Hospital.ICUDisSixMonthOutcomeUnfavourable Expected risk of unfavourable outcome (D, VS, SD) at 6 months At ICU discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ICU". This reflects the risk of unfavorable outcome (D,VS,SD) in %
Hospital.ICUDisSupportWithdrawnDate Date of withdrawal of support This variable documents date and time at which life prolonging therapy was withdrawn (together with "Hospital.ICUDisSupportWithdrawnTime")
Hospital.ICUDisSupportWithdrawnTime Time of withdrawal of support This variable documents date and time at which life prolonging therapy was withdrawn (together with "Hospital.ICUDisSupportWithdrawnDate")
Hospital.ICUDisTimeToObeyCommands Time to obey commands Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression.
Hospital.ICUDisTimeToObeyCommandsNA Time to obey commands at discharge Not applicable Pre-defined early endpoints recorded at ICU discharge include: neuroworsening (any episode), time to obeying commands, duration of PTA, duration of ventilation, number of CTs performed and CT progression. This reflects if 'Time to obey commands' was Not applicable.
Hospital.ICUDisWithdrawalTreatmentDecisionDate Date of decision to withdraw active treatment Investigators were requested to record the details of Withdrawal of Treatment or Life support if applicable.
Hospital.ICUDisWithdrawalTreatmentDecisionTime Time of decision to withdraw active treatment Investigators were requested to record the details of Withdrawal of Treatment or Life support if applicable.
Hospital.ICUDisWithdrawlTreatmentDecision Decision to withdraw active treatment 1 == Multi disciplinary
2 == By a single physician
3 == With relatives
Investigators were requested to record the details of Withdrawal of Treatment or Life support if applicable.
Hospital.ICUEndTidalCO2 End Tidal CO2 0 == No
1 == Yes
Reflects the type, in case of systemic monitoring on ICU: End Tidal CO2
Hospital.ICUGCSDischargeEyes Eye opening (E) response at ICU discharge 1 == 1-None
2 == 2-To pain
3 == 3-To speech
S == Untestable (swollen)
88 == Unknown
4 == 4-Spontaneously
O == Untestable (other)
Eye opening score for GCS at ICU discharge.
Hospital.ICUGCSDischargeMotor Motor (M) response at ICU discharge O == Untestable (Other)
1 == 1-None
2 == 2-Abnormal extension
3 == 3-Abnormal flexion
4 == 4-Normal flexion/withdrawal
5 == 5-Localizes to pain
P == Untestable (Deep sedation/paralyzed)
6 == 6-Obeys command
UN == Unknown
Motor score for GCS at ICU discharge.
Hospital.ICUGCSDischargeScore GCS score at ICU discharge GCS score at ICU discharge.
Hospital.ICUGCSDischargeVerbal Verbal (V) response at ICU discharge 5 == 5-Oriented
1 == 1-None
2 == 2-Incomprehensible sound
3 == 3-Inappropriate words
4 == 4-Confused
T == Untestable (tracheotomy/endotracheal tube)
P == Untestable (tracheotomy/endotracheal tube)
O == Untestable (Other)
UN == Unknown
Verbal score for GCS at ICU discharge.
Hospital.ICUInvasiveBP Invasive BP monitoring 0 == No
1 == Yes
Reflects the type, in case of systemic monitoring on ICU: Invasive BP monitoring
Hospital.ICUProblemsICP Any there any problems in ICP monitoring? 0 == No
1 == Yes
In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable reflects Problems in ICP monitoring.
Hospital.ICUProblemsICPYes Explain ICP problems 1 == Accidental catheter removal
2 == Catheter obstruction/failure
3 == Suspicion of inaccurate measurement
In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable explains the Problems in ICP monitoring if applicable.
Hospital.ICUPulseOximetry Pulse oximetry 0 == No
1 == Yes
Reflects the type, in case of systemic monitoring on ICU: Pulse oximetry
Hospital.ICURaisedICP Raised ICP (sustained) 0 == No
1 == Yes, controlled
2 == Yes, refractory
In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable reflects if there was Raised ICP (sustained).
Hospital.ICUReasonForTypeICPMont Reason for the choice of ventricular/ventricular and sensor monitoring 1 == Routine in our department
2 == Not routine, but enlarged ventricles
3 == No parenchymal device available
99 == Other
In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable reflects WHY Question: reason for choosing ventricular monitor
Hospital.ICUReasonForTypeICPMontPare Reason for choice of parenchymal sensor 1 == Routine in our department
2 == Not routine, but small ventricles
3 == Mainly motivated by time of day
4 == No OR available for placement ventr. catheter
5 == Failed implantation ventricular catheter
99 == Other
In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable reflects WHY Question: reason for choosing parenchymal monitor.
Hospital.ICUReasonForTypeICUMontOther Other reason for the choice of ventricular/ventricular sensor monitoring (please specify) In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable reflects "Other Reason of choice for ventricular/ventricular+sensor monitoring"
Hospital.ICUReasonForTypeICUMontParOther Other reason for the choice of parenchymal sensor (please specify) In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable reflects 'Other Reason of choice for parenchymal sensor'.
Hospital.ICUReasonICP Reasons for monitoring ICP 1 == Guideline criteria
2 == Radiological signs raised ICP
3 == Clinical suspicion raised ICP
4 == Anaesthesia or mechanical ventilation required for extracranial injuries
5 == To inform surgical indication for mass lesion
99 == Other
In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable reflects WHY Question: documents reason for monitoring ICP in patient admitted to ICU
Hospital.ICUReasonICPOther Other reason for ICP monitoring (please specify) In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable is a free text field for description of why the patient has ICP monitoring if there is another reason than pre-specified in Hospital.ICUReasonICP.
Hospital.ICUReasonNoICP Reason for NOT monitoring ICP 1 == GCS >8
2 == No radiological signs of raised ICP
3 == Risk of raised ICP considered low
4 == Patient considered unsalvageable
5 == Coagulopathy
6 == Use of anticoagulants or platelet aggregation inhibitors
7 == No device available
8 == Not local policy to monitor ICP
9 == Too costly
99 == Other
In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable reflects WHY Question: documents reason for not monitoring ICP in patient admitted to ICU
Hospital.ICUReasonNoICPOther Other reason for NOT monitoring ICP (please specify) In case of brain specific monitoring in the ICU, all details on the ICP monitoring were recorded. This variable is a free text field for description of the reason why ICP has not been monitored in ICU patient if there is another reason than pre-specified in Hospital.ICUReasonNoICP.
Hospital.MonContEGG Continuous EEG 0 == No
1 == Yes
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects if there was continuous EEG monitoring.
Hospital.MonContEGGDuration Duration of Continuous EEG Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects the duration if there was continuous EEG monitoring.
Hospital.MonECoG ECoG (Electrocorticography) 0 == No
1 == Yes
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects if there was continuous ECoG monitoring.
Hospital.MonECoGDuration Duration of ECoG (Electrocorticography) Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects the duration if there was continuous EEG monitoring.
Hospital.MonJugularDesatEpisodes Jugular desaturation episodes (<50%) 0 == No
1 == Yes
77 == N/A
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects if there were Jugular desaturation episodes (<50%).
Hospital.MonJugularSatDuration Duration of Jugular oximetry Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects the duration if there was Jugular oximetry.
Hospital.MonJugularSatStopReason Reason for stopping Jugular oximetry 4 == Clinically no longer required
3 == Patient died
2 == Patient considered unsalvageable
1 == Monitor/catheter failure
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects the reason for stopping if there was Jugular oximetry.
Hospital.MonJugularSatUsed Jugular oximetry 1 == Yes
0 == No
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects if there was Jugular oximetry.
Hospital.MonLicoxDuration Duration of Brain tissue PO2 Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects the duration if there was Brain tissue PO2 monitoring.
Hospital.MonLicoxPO2 Brain tissue PO2 < 15 mmHg 0 == No
1 == Yes
77 == N/A
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects if there was Brain tissue PO2 <15mmHg monitoring.
Hospital.MonLicoxStopReason Reason for stopping Brain tissue PO2 4 == Clinically no longer required
3 == Patient died
2 == Patient considered unsalvageable
1 == Monitor/catheter failure
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects the reason for stopping if there was Brain tissue PO2 monitoring.
Hospital.MonLicoxUsed Brain tissue PO2 0 == No
1 == Yes
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects if there was Brain tissue PO2 monitoring.
Hospital.MonMicrodialysisDuration Duration of Microdialysis Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects the duration if there was Microdialysis.
Hospital.MonMicrodialysisStopReason Reason for stopping Microdialysis 1 == Monitor/catheter failure
2 == Patient considered unsalvageable
3 == Patient died
4 == Clinically no longer required
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects the reason for stopping if there was Microdialysis.
Hospital.MonMicrodialysisUsed Microdialysis 0 == No
1 == Yes
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects if there was Microdialysis.
Hospital.MonTranscranDoppler Transcranial Doppler 0 == No
1 == Yes
Beside brain specific ICP monitoring in the ICU, details were recorded on other types of monitoring in the ICU. This variable reflects if there was Transcranial Doppler monitoring.
Hospital.OrganDonationDate Date of organ donation Reflects the date of organ donation in case of Withdrawal of life-sustaining measures, if applicable.
Hospital.OrganDonationTime Time of organ donation Reflects the time of organ donation in case of Withdrawal of life-sustaining measures, if applicable.
Hospital.SixMonthOutcomeDate Date of prognostic estimate of 6 month outcome At hospital discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge from hospital". This same information was also recorded for discharge specifically from ICU. This reflects the Date of prognostic estimate.
Hospital.SixMonthOutcomeGOS Expected GOS (Glasgow Outcome Scale) at 6 months D == Death
V == Vegetative state
SD == Severe Disability
MD == Moderate Disability
GR == Good Recovery
At hospital discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge from hospital". This same information was also recorded for discharge specifically from ICU. This reflects the Expected outcome (GOS).
Hospital.SixMonthOutcomeQualification Qualification of the physician estimating the six month outcome 1 == Resident
2 == Junior staff (< 5 years)
3 == Senior staff ( >5 years)
4 == Head of department
At hospital discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge from hospital". This same information was also recorded for discharge specifically from ICU. This reflects the qualification of the physician who provided prognostic estimate on hospital discharge
Hospital.SixMonthOutcomeType Type of the physician estimating the six month outcome 1 == ER physician
2 == Intensive care physician
3 == Neurology
4 == Neurosurgery
5 == Traumatology
88 == Unknown
99 == Other
At hospital discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge from hospital". This same information was also recorded for discharge specifically from ICU. This reflects the type of the physician who provided prognostic estimate on hospital discharge.
Hospital.SixMonthOutcomeUnfavourable Expected risk of unfavourable outcome (D, VS, SD) at 6 months At hospital discharge, physician estimate of six month outcome was recorded: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge from hospital". This same information was also recorded for discharge specifically from ICU. This reflects the Risk of unfavorable outcome (D,VS,SD) in %
Hospital.SupportWithdrawnDate Date of withdrawal of support Investigators were requested to record the details of Withdrawal of Treatment or Life support if applicable.
Hospital.SupportWithdrawnTime Time of withdrawal of support Investigators were requested to record the details of Withdrawal of Treatment or Life support if applicable.
Hospital.TimeSinceICUAdmisDeath Time between admission in the ICU and death Investigators were requested to record the details of Withdrawal of Treatment or Life support if applicable. This reflects the time between admission in the ICU and death
Hospital.WardAdmDate Date of admission to Ward Date of admission to the ward In principle the date of injury; date of enrollment and Date of Admission to Ward will match, but in some cases there can be a difference of 1 or 2 days. For example when a patient was injured late at night, it is possible that the consent was only obtained in the morning, hence the date of Study Enrollment will be 1 day later than the date of injury. Or in some hospitals a patient is kept for 24 hours in observation at the ER in a specific unit before being transferred to ICU or Ward. Hence the Date of Admission to ICU or Ward can be 1 or 2 days later. Or if there is no bed available on ICU or Ward for a patient being injured late at night, there can be a delay in admitting the patient.
Hospital.WardAdmReason Reason for admission to Ward 10 == Could be discharged home, but no adequate supervision
9 == No ICU bed available
8 == Clinical observation for TBI
4 == Extracranial injuries
7 == CT abnormalities
99 == Other
WHY question: documents main reason for admission to ward (and not to ICU or discharge home)
Hospital.WardAdmReasonOther Other reason for admission to Ward If the variable WardAdmReason was set to Other the reason for admission to the ward is filled in here.
Hospital.WardAdmTime Time of admission to Ward Time of admission to the ward
Hospital.WithdrawalTreatmentDecision Decision to withdraw active treatment 1 == Multi disciplinary
2 == By a single physician
3 == With relatives
Intended only to be scored if a medical decision was made to withdraw active treatment because of anticipated poor prognosis. However, some investigators may have scored this when patients had recovered to an extent that active treatment was no longer necessary.
Hospital.WithdrawalTreatmentDecisionDate Date of decision to withdraw active treatment Investigators were requested to record the details of Withdrawal of Treatment or Life support if applicable. Intended only to be scored if a medical decision was made to withdraw active treatment because of anticipated poor prognosis. However, some investigators may have scored this when patients had recovered to an extent that active treatment was no longer necessary.
Hospital.WithdrawalTreatmentDecisionTime Time of decision to withdraw active treatment Investigators were requested to record the details of Withdrawal of Treatment or Life support if applicable. Intended only to be scored if a medical decision was made to withdraw active treatment because of anticipated poor prognosis. However, some investigators may have scored this when patients had recovered to an extent that active treatment was no longer necessary.
HourlyMeasurements.DaySinceInjury Calculated day since injury for hourly measurements Calculated from HourlyValues.HVDate and Subject.DateInj
HourlyMeasurements.HVCPP Normalized datay for HVCPP2, HVCPP4, ect (calculated) Normalized data for HVCPP2, HVCPP 4 etc. Calculated from MAP-ICP (HVSBP+2*HVDBP)/3-HVICP.
HourlyMeasurements.HVDateTime Calulated date and time for hourly value measurements The date and time manually entered for the measurements in HourlyValues at time 2,4,6... are combined into this variable to match the entries in the HourlyMeasurements variables for HVSBP, HVDBP, HVICP.
HourlyMeasurements.HVDBP All diastolic blood pressures combined All diastolic blood pressures combined into one variable, measured twice hourly. To get intended measurement time, see HourlyMeasurements.HVMeasurementDateTime.
HourlyMeasurements.HVICP All intracranial pressures combined All intracranial pressures combined into one variable, measured twice hourly. To get intended measurement time, see HourlyMeasurements.HVMeasurementDateTime.
HourlyMeasurements.HVMeasurementDateTime Derived intended date and time for all hourly values measurements The intended date and time for all hourly values measurements (HVSBP, HVDBP, HVICP, HVCPP) derived from HVDate+HVTimeX where HVTimeX is HVTime2->02.00, HVTime4->04.00,..., HVTime24->23.59.
HourlyMeasurements.HVSBP All systolic blood pressures combined All systolic blood pressures combined into one variable, measured twice hourly. To get intended measurement time, see HourlyMeasurements.HVMeasurementDateTime.
HourlyMeasurements.HVTIL Combination of all hourly TIL values in a long format Investigators were requested to document any change in TIL at 4 hour intervals (6 times per day), in a way that corresponds with the documentation of hourly values (04:00-08:00-12:00-16:00-20:00-24:00). This variable combines the hourly TIL values and represents in a long format these hourly measurements. See also HourlyValues.HVTIL4, HourlyValues.HVTIL8, HourlyValues.HVTIL12, HourlyValues.HVTIL16, HourlyValues.HVTIL20, HourlyValues.HVTIL24
HourlyValues.HourlyValueAccurate Are measured values for ICP over this day considered accurate? 0 == No
2 == Doubtful
1 == Yes
Are the measured values for ICP over this day considered to be accurate? An explanation can be found in HourlyValues.HourlyValueNotAccurateProblems. Associated with the date in HourlyValues.HVDate.
HourlyValues.HourlyValueICPDiscontinued Was active ICP treatment discontinued (poor prognosis)? 0 == No
1 == Yes
Answer to the question: "Was active ICP treatment discontinued (due to poor prognosis)?"
HourlyValues.HourlyValueLevelABP Level for zeroing ABP 1 == Right atrium
2 == Level of arterial catheter
99 == Other
Differences in level of zeroing the arterial blood pressure transducer may affect calculations of CPP and comparisons between centres.
HourlyValues.HourlyValueLevelABPOther Other level for zeroing ABP (please specify) A free text description of the level of ABP transducer if HourlyValues.HourlyValueLevelABP is "other".
HourlyValues.HourlyValueLevelICP Level for zeroing ICP 1 == Foramen of Monro
2 == Same level as ABP
3 == Meatus externus (ear)
Only applicable in case ICP monitored; Differences in level of zeroing ICP may affect calculation of CPP and comparisons between centres.
HourlyValues.HourlyValueNotAccurateProblems Why the measured values for ICP over this day are not considered accurate? Explanation in free text of the variable HourlyValues.HourlyValueAccurate. Associated with the date in HourlyValues.HVDate.
HourlyValues.HVCPP10 CPP associated with the Hourly value DateTime10 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime10. Calculated by the equation HVCPP10 = (HVSBP10+ 2*HVDBP10)/3-HVICP10. It is set to NA if any of the values in the equation is missing or HVICP10 is 0.
HourlyValues.HVCPP12 CPP associated with the Hourly value DateTime12 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime12. Calculated by the equation HVCPP12 = (HVSBP12+ 2*HVDBP12)/3-HVICP12. It is set to NA if any of the values in the equation is missing or HVICP12 is 0.
HourlyValues.HVCPP14 CPP associated with the Hourly value DateTime14 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime14. Calculated by the equation HVCPP14 = (HVSBP14+ 2*HVDBP14)/3-HVICP14. It is set to NA if any of the values in the equation is missing or HVICP14 is 0.
HourlyValues.HVCPP16 CPP associated with the Hourly value DateTime16 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime16. Calculated by the equation HVCPP16 = (HVSBP16+ 2*HVDBP16)/3-HVICP16. It is set to NA if any of the values in the equation is missing or HVICP16 is 0.
HourlyValues.HVCPP18 CPP associated with the Hourly value DateTime18 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime18. Calculated by the equation HVCPP18 = (HVSBP18+ 2*HVDBP18)/3-HVICP18. It is set to NA if any of the values in the equation is missing or HVICP18 is 0.
HourlyValues.HVCPP2 CPP associated with the Hourly value DateTime2 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime2. This variable is calculated by HVCPP2 = (HVSBP2+2*HVDBP2)/3 - HVICP2. It is set to NA if any of the values in the equation is missing or HVICP2 is 0.
HourlyValues.HVCPP20 CPP associated with the Hourly value DateTime20 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime20. Calculated by the equation HVCPP20 = (HVSBP20+ 2*HVDBP20)/3-HVICP20. It is set to NA if any of the values in the equation is missing or HVICP20 is 0.
HourlyValues.HVCPP22 CPP associated with the Hourly value DateTime22 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime22. Calculated by the equation HVCPP22 = (HVSBP22+ 2*HVDBP22)/3-HVICP22. It is set to NA if any of the values in the equation is missing or HVICP22 is 0.
HourlyValues.HVCPP24 CPP associated with the Hourly value DateTime24 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime24. Calculated by the equation HVCPP24 = (HVSBP24+ 2*HVDBP24)/3-HVICP24. It is set to NA if any of the values in the equation is missing or HVICP24 is 0.
HourlyValues.HVCPP4 CPP associated with the Hourly value DateTime4 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime4. This variable is calculated by the equation HVCPP4 = (HVSBP4+ 2*HVDBP4)/3-HVICP4. It is set to NA if any of the values in the equation is missing or HVICP2 is 0.
HourlyValues.HVCPP6 CPP associated with the Hourly value DateTime6 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime6. Calculated by the equation HVCPP6 = (HVSBP6+ 2*HVDBP6)/3-HVICP6. It is set to NA if any of the values in the equation is missing or HVICP6 is 0.
HourlyValues.HVCPP8 CPP associated with the Hourly value DateTime8 The cerebral perfusion pressure, CPP, associated with the HourlyValues.HVDateTime8. Calculated by the equation HVCPP8 = (HVSBP8+ 2*HVDBP8)/3-HVICP8. It is set to NA if any of the values in the equation is missing or HVICP8 is 0.
HourlyValues.HVDate Date value is recorded The date the hourly values are measured.
HourlyValues.HVDBP10 Diastolic BP associated with the Hourly value DateTime10 The diastolic blood pressure associated with HourlyValues.HVDateTime10.
HourlyValues.HVDBP12 Diastolic BP associated with the Hourly value DateTime12 The diastolic blood pressure associated with HourlyValues.HVDateTime12.
HourlyValues.HVDBP14 Diastolic BP associated with the Hourly value DateTime14 The diastolic blood pressure associated with HourlyValues.HVDateTime14.
HourlyValues.HVDBP16 Diastolic BP associated with the Hourly value DateTime16 The diastolic blood pressure associated with HourlyValues.HVDateTime16.
HourlyValues.HVDBP18 Diastolic BP associated with the Hourly value DateTime18 The diastolic blood pressure associated with HourlyValues.HVDateTime18.
HourlyValues.HVDBP2 Diastolic BP associated with the Hourly value DateTime2 The diastolic blood pressure associated with HourlyValues.HVDateTime2.
HourlyValues.HVDBP20 Diastolic BP associated with the Hourly value DateTime20 The diastolic blood pressure associated with HourlyValues.HVDateTime20.
HourlyValues.HVDBP22 Diastolic BP associated with the Hourly value DateTime22 The diastolic blood pressure associated with HourlyValues.HVDateTime22.
HourlyValues.HVDBP24 Diastolic BP associated with the Hourly value DateTime24 The diastolic blood pressure associated with HourlyValues.HVDateTime24.
HourlyValues.HVDBP4 Diastolic BP associated with the Hourly value DateTime4 The diastolic blood pressure associated with HourlyValues.HVDateTime4.
HourlyValues.HVDBP6 Diastolic BP associated with the Hourly value DateTime6 The diastolic blood pressure associated with HourlyValues.HVDateTime6.
HourlyValues.HVDBP8 Diastolic BP associated with the Hourly value DateTime8 The diastolic blood pressure associated with HourlyValues.HVDateTime8.
HourlyValues.HVICP10 ICP associated with the Hourly value DateTime10 The intracranial pressure associated with HourlyValues.HVDateTime10.
HourlyValues.HVICP12 ICP associated with the Hourly value DateTime12 The intracranial pressure associated with HourlyValues.HVDateTime12.
HourlyValues.HVICP14 ICP associated with the Hourly value DateTime14 The intracranial pressure associated with HourlyValues.HVDateTime14.
HourlyValues.HVICP16 ICP associated with the Hourly value DateTime16 The intracranial pressure associated with HourlyValues.HVDateTime16.
HourlyValues.HVICP18 ICP associated with the Hourly value DateTime18 The intracranial pressure associated with HourlyValues.HVDateTime18.
HourlyValues.HVICP2 ICP associated with the Hourly value DateTime2 The intracranial pressure associated with HourlyValues.HVDateTime2.
HourlyValues.HVICP20 ICP associated with the Hourly value DateTime20 The intracranial pressure associated with HourlyValues.HVDateTime20.
HourlyValues.HVICP22 ICP associated with the Hourly value DateTime22 The intracranial pressure associated with HourlyValues.HVDateTime22.
HourlyValues.HVICP24 ICP associated with the Hourly value DateTime24 The intracranial pressure associated with HourlyValues.HVDateTime24.
HourlyValues.HVICP4 ICP associated with the Hourly value DateTime4 The intracranial pressure associated with HourlyValues.HVDateTime4.
HourlyValues.HVICP6 ICP associated with the Hourly value DateTime6 The intracranial pressure associated with HourlyValues.HVDateTime6.
HourlyValues.HVICP8 ICP associated with the Hourly value DateTime8 The intracranial pressure associated with HourlyValues.HVDateTime8.
HourlyValues.HVSBP10 Systolic BP associated with the Hourly value DateTime10 The systolic blood pressure associated with HourlyValues.HVDateTime10.
HourlyValues.HVSBP12 Systolic BP associated with the Hourly value DateTime12 The systolic blood pressure associated with HourlyValues.HVDateTime12.
HourlyValues.HVSBP14 Systolic BP associated with the Hourly value DateTime14 The systolic blood pressure associated with HourlyValues.HVDateTime14.
HourlyValues.HVSBP16 Systolic BP associated with the Hourly value DateTime16 The systolic blood pressure associated with HourlyValues.HVDateTime16.
HourlyValues.HVSBP18 Systolic BP associated with the Hourly value DateTime18 The systolic blood pressure associated with HourlyValues.HVDateTime18.
HourlyValues.HVSBP2 Systolic BP associated with the Hourly value DateTime2 The systolic blood pressure associated with HourlyValues.HVDateTime2.
HourlyValues.HVSBP20 Systolic BP associated with the Hourly value DateTime20 The systolic blood pressure associated with HourlyValues.HVDateTime20.
HourlyValues.HVSBP22 Systolic BP associated with the Hourly value DateTime22 The systolic blood pressure associated with HourlyValues.HVDateTime22.
HourlyValues.HVSBP24 Systolic BP associated with the Hourly value DateTime24 The systolic blood pressure associated with HourlyValues.HVDateTime24.
HourlyValues.HVSBP4 Systolic BP associated with the Hourly value DateTime4 The systolic blood pressure associated with HourlyValues.HVDateTime4.
HourlyValues.HVSBP6 Systolic BP associated with the Hourly value DateTime6 The systolic blood pressure associated with HourlyValues.HVDateTime6.
HourlyValues.HVSBP8 Systolic BP associated with the Hourly value DateTime8 The systolic blood pressure associated with HourlyValues.HVDateTime8.
HourlyValues.HVTIL12 Change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 0 == No change
1 == Increasing intensity
2 == Decreasing intensity
Investigators were requested to document any change in TIL at 4 hour intervals (6 times per day), in a way that corresponds with the documentation of hourly values (04:00-08:00-12:00-16:00-20:00-24:00)
HourlyValues.HVTIL16 Change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 0 == No change
1 == Increasing intensity
2 == Decreasing intensity
Investigators were requested to document any change in TIL at 4 hour intervals (6 times per day), in a way that corresponds with the documentation of hourly values (04:00-08:00-12:00-16:00-20:00-24:00)
HourlyValues.HVTIL20 Change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 0 == No change
1 == Increasing intensity
2 == Decreasing intensity
Investigators were requested to document any change in TIL at 4 hour intervals (6 times per day), in a way that corresponds with the documentation of hourly values (04:00-08:00-12:00-16:00-20:00-24:00)
HourlyValues.HVTIL24 Change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 0 == No change
1 == Increasing intensity
2 == Decreasing intensity
Investigators were requested to document any change in TIL at 4 hour intervals (6 times per day), in a way that corresponds with the documentation of hourly values (04:00-08:00-12:00-16:00-20:00-24:00)
HourlyValues.HVTIL4 Change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 0 == No change
1 == Increasing intensity
2 == Decreasing intensity
Investigators were requested to document any change in TIL at 4 hour intervals (6 times per day), in a way that corresponds with the documentation of hourly values (04:00-08:00-12:00-16:00-20:00-24:00)
HourlyValues.HVTIL8 Change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 0 == No change
1 == Increasing intensity
2 == Decreasing intensity
Investigators were requested to document any change in TIL at 4 hour intervals (6 times per day), in a way that corresponds with the documentation of hourly values (04:00-08:00-12:00-16:00-20:00-24:00)
HourlyValues.HVTILChangeReason12 Reason for change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 1 == Intensified: Clinical deterioration
2 == Intensified: Suspicion of increased of ICP (not measured)
3 == Intensified: Increased ICP (documented)
4 == Intensified:Clinical decision to target other mechanism
5 == Intensified:Change of doctor (different shift)
6 == Decreasing:Clinical improvement
7 == Decreasing:Adequate control over ICP
8 == Decreasing:Upper treatment limit reached/past
9 == Decreasing: Further treatment considered futile
10 == Decreasing: Change of doctor (different shift)
WHY question: Differentiated for: - Intensified: Clinical deterioration - Intensified: Suspicion of increased of ICP - Intensified: increased ICP (documented) - Intensified:Clinical decision to target other mechanism - Intensified:Change of doctor (different shift) - Decreasing:Clinical improvement - Decreasing:Adequate control over ICP - Decreasing:Upper treatment limit reached/past - Decreasing: Further treatment considered futile - Decreasing: Change of doctor (different shift). The hours at which the reasons for change are documented should correspond to the hours for documentation of any change in TIL; documentation of reason is only required in case of a change in TIL
HourlyValues.HVTILChangeReason16 Reason for change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 1 == Intensified: Clinical deterioration
2 == Intensified: Suspicion of increased of ICP (not measured)
3 == Intensified: Increased ICP (documented)
4 == Intensified:Clinical decision to target other mechanism
5 == Intensified:Change of doctor (different shift)
6 == Decreasing:Clinical improvement
7 == Decreasing:Adequate control over ICP
8 == Decreasing:Upper treatment limit reached/past
9 == Decreasing: Further treatment considered futile
10 == Decreasing: Change of doctor (different shift)
WHY question: Differentiated for: - Intensified: Clinical deterioration - Intensified: Suspicion of increased of ICP - Intensified: increased ICP (documented) - Intensified:Clinical decision to target other mechanism - Intensified:Change of doctor (different shift) - Decreasing:Clinical improvement - Decreasing:Adequate control over ICP - Decreasing:Upper treatment limit reached/past - Decreasing: Further treatment considered futile - Decreasing: Change of doctor (different shift). The hours at which the reasons for change are documented should correspond to the hours for documentation of any change in TIL; documentation of reason is only required in case of a change in TIL
HourlyValues.HVTILChangeReason20 Reason for change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 1 == Intensified: Clinical deterioration
2 == Intensified: Suspicion of increased of ICP (not measured)
3 == Intensified: Increased ICP (documented)
4 == Intensified:Clinical decision to target other mechanism
5 == Intensified:Change of doctor (different shift)
6 == Decreasing:Clinical improvement
7 == Decreasing:Adequate control over ICP
8 == Decreasing:Upper treatment limit reached/past
9 == Decreasing: Further treatment considered futile
10 == Decreasing: Change of doctor (different shift)
WHY question: Differentiated for: - Intensified: Clinical deterioration - Intensified: Suspicion of increased of ICP - Intensified: increased ICP (documented) - Intensified:Clinical decision to target other mechanism - Intensified:Change of doctor (different shift) - Decreasing:Clinical improvement - Decreasing:Adequate control over ICP - Decreasing:Upper treatment limit reached/past - Decreasing: Further treatment considered futile - Decreasing: Change of doctor (different shift). The hours at which the reasons for change are documented should correspond to the hours for documentation of any change in TIL; documentation of reason is only required in case of a change in TIL
HourlyValues.HVTILChangeReason24 Reason for change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 1 == Intensified: Clinical deterioration
2 == Intensified: Suspicion of increased of ICP (not measured)
3 == Intensified: Increased ICP (documented)
4 == Intensified:Clinical decision to target other mechanism
5 == Intensified:Change of doctor (different shift)
6 == Decreasing:Clinical improvement
7 == Decreasing:Adequate control over ICP
8 == Decreasing:Upper treatment limit reached/past
9 == Decreasing: Further treatment considered futile
10 == Decreasing: Change of doctor (different shift)
WHY question: Differentiated for: - Intensified: Clinical deterioration - Intensified: Suspicion of increased of ICP - Intensified: increased ICP (documented) - Intensified:Clinical decision to target other mechanism - Intensified:Change of doctor (different shift) - Decreasing:Clinical improvement - Decreasing:Adequate control over ICP - Decreasing:Upper treatment limit reached/past - Decreasing: Further treatment considered futile - Decreasing: Change of doctor (different shift). The hours at which the reasons for change are documented should correspond to the hours for documentation of any change in TIL; documentation of reason is only required in case of a change in TIL
HourlyValues.HVTILChangeReason4 Reason for change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 1 == Intensified: Clinical deterioration
2 == Intensified: Suspicion of increased of ICP (not measured)
3 == Intensified: Increased ICP (documented)
4 == Intensified:Clinical decision to target other mechanism
5 == Intensified:Change of doctor (different shift)
6 == Decreasing:Clinical improvement
7 == Decreasing:Adequate control over ICP
8 == Decreasing:Upper treatment limit reached/past
9 == Decreasing: Further treatment considered futile
10 == Decreasing: Change of doctor (different shift)
WHY question: Differentiated for: - Intensified: Clinical deterioration - Intensified: Suspicion of increased of ICP - Intensified: increased ICP (documented) - Intensified:Clinical decision to target other mechanism - Intensified:Change of doctor (different shift) - Decreasing:Clinical improvement - Decreasing:Adequate control over ICP - Decreasing:Upper treatment limit reached/past - Decreasing: Further treatment considered futile - Decreasing: Change of doctor (different shift). The hours at which the reasons for change are documented should correspond to the hours for documentation of any change in TIL; documentation of reason is only required in case of a change in TIL
HourlyValues.HVTILChangeReason8 Reason for change in TIL at 4 hours interval (4, 8, 12 ,16, 20, 24) 1 == Intensified: Clinical deterioration
2 == Intensified: Suspicion of increased of ICP (not measured)
3 == Intensified: Increased ICP (documented)
4 == Intensified:Clinical decision to target other mechanism
5 == Intensified:Change of doctor (different shift)
6 == Decreasing:Clinical improvement
7 == Decreasing:Adequate control over ICP
8 == Decreasing:Upper treatment limit reached/past
9 == Decreasing: Further treatment considered futile
10 == Decreasing: Change of doctor (different shift)
WHY question: Differentiated for: - Intensified: Clinical deterioration - Intensified: Suspicion of increased of ICP - Intensified: increased ICP (documented) - Intensified:Clinical decision to target other mechanism - Intensified:Change of doctor (different shift) - Decreasing:Clinical improvement - Decreasing:Adequate control over ICP - Decreasing:Upper treatment limit reached/past - Decreasing: Further treatment considered futile - Decreasing: Change of doctor (different shift). The hours at which the reasons for change are documented should correspond to the hours for documentation of any change in TIL; documentation of reason is only required in case of a change in TIL
HourlyValues.HVTime10 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime12 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime14 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime16 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime18 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime2 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators were allowed to enter another timepoint in this field.
HourlyValues.HVTime20 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime22 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime24 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime4 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime6 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
HourlyValues.HVTime8 Hourly values at 2h interval 12 times a day (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24) Investigators were requested to document hourly values every 2 hours (12 times per day) for all patients receiving ICP monitoring. The timeperiods were pre-specified (02:00-24:00); however, investigators may have entered values at different times and have then entered the time of obtaining hourly values; a possible confusion may exist if investigators entered the time of documenting the hourly values rather than the time at which they were obtained.
Imaging.AcquisitionDate Date of acquisition Acquisition date and time for each scan of an entire session - retrieved from the DICOM header
Imaging.AcquisitionTime Time of acquisition Acquisition date and time for each scan of an entire session - retrieved from the DICOM header
Imaging.AnyIntracranTraumaticAbnormality Any intracranial traumatic abnormality? This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether any of the 12 following CDEs is present (Mass lesion, ExtraaxialHematoma, EpiduralHematoma, SubduralHematomaAcute, SubduralHematomaSubacuteChronic, SubduralCollectionMixedDensity, Contusion, TAI, traumaticSubarachnoidHemorrhage, IntraventricularHemorrhage, MidlineShift or CisternalCompression.
Imaging.BvalURL Bval URL This variable is an URL towards the generated Bval file.
Imaging.BvecURL Bvec URL This variable is an URL towards the generated Bvec file.
Imaging.CisternalCompression Cisternal Compression This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether there is compression of one or more the basal cisterns (i.e. suprasellar, quadrigeminal, prepontine, ambient, cisterna magna). More descriptive information (location, compression vs. absence) can be found in the JSON files.
Imaging.Contusion Contusion (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether one or more contusions are present. More descriptive information (location, volume, number) and advanced information (e.g. hemorrhagic, non-hemorrhagic, intracerebral hemorrhage, etc.) can be found in the JSON files. Volume was estimated using the AxBxC/2 method. Edema was included in the measurements.
Imaging.CRFCTAngulation CT Angulation This variable describes if a CT scan is performed with or without angulation. There are three options: no angulation (volume scan), orbital-meatal line and other. There is a risk of different interpretation, since there was no definition.
Imaging.CRFCTManuf CT scanner manufacturer This variable describes the CT scans manufacturer.
Imaging.CRFCTMidlineShift Midline shift CT parameters scored by the investigator: reflects if there was midline shift on the CT.
Imaging.CRFCTMidlineShiftMeasure Midline shift (please specify) CT parameters scored by the investigator: reflects the volume in mm if there was a midline shift on the CT Check also "Imaging.CRFCTMidlineShift"
Imaging.CRFCTMRIDate Date of imaging captured in CRF Date of Imaging captured in CRF
Imaging.CRFCTMRITime Time of imaging captured in CRF Time of imaging captured in CRF
Imaging.CRFCTReason Reason for CT scan This variable contains the main reason why a CT-scan, during hospital stay, was performed. One of following options: standard follow-up, post-operative control, clinical deterioration, (suspicion of) increasing ICP, lack of improvement, unknown, other (specified in CTMRI.CTReasonOther) The reason for making an early CT-scan/ER scan can be found in: CTMRI.CTERReason
Imaging.CRFCTScannerType Type of CT scanner This variable specifies the type of CT-scanner by the number of slices.
Imaging.CRFCTType CT type This variable describes the type of CT scan that has been made. Multiple options can be selected from: Non-contrast CT, Contrast CT, CT Angiography, Perfusion CT.
Imaging.CRFForm CRF used at the time of scan Acute or follow up form in the e-CRF.
Imaging.CRFIcometrixImageId Icometrix image ID This variable combines data from CTMRI.IcometrixImageId and FollowUp.IcometrixImageId. Identifier generated for an imaging experiment when images are uploaded from site.
Imaging.CRFIcometrixPassedQA Images passed QA of icometrix Reflects if images uploaded from site passed QA of icometix. This variable combines data from CTMRI.IcometrixPassedQA and FollowUp.IcometrixPassedQA.
Imaging.CRFInitialDataIcometrix Imaging data in CRF loaded from icometrix (not by study nurse) Reflects if the imaging data was initially loaded from Icometrix into the e-CRF (if not, it means the data in the e-CRF was entered manually by the study nurse) This variable combines data from CTMRI.InitialDataIcometrix and FollowUp.InitialDataIcometrix.
Imaging.CRFMRIManuf MRI scanner manufacturer This variable describes the MRI-scan manufacturer. This variable combines data from CTMRI.MRIManuf and FollowUp.MRIManuf
Imaging.CRFMRIReason Reason for MRI scan This variable contains the main reason why an MRI was performed. This variable combines data from CTMRI.MRIReason and FollowUp.MRIReason
Imaging.CRFMRIReasonOther Other reason for MRI scan (please specify) This variable contains the main reason why an MRI was performed, when in the variable "MRIReason", the option "other" was chosen. This is a text field. This variable combines data from CTMRI.MRIReasonOther and FollowUp.MRIReasonOther
Imaging.CRFMRIResultPreExistAbnorm MRI scan results: Pre-existing abnormalities This variable describes whether or not there are pre-existing abnormalities present on MRI scan (yes, no, unknown). Assessment by investigator and or physician. This variable combines data from CTMRI.MRIResultPreExistAbnorm and FollowUp.MRIResultPreExistAbnorm
Imaging.CRFMRIResultTraumaticAbnorm MRI scan results: Traumatic abnormalities This variable describes whether or not there are traumatic abnormalities present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRIResultTraumaticAbnorm and FollowUp.MRIResultTraumaticAbnorm
Imaging.CRFMRIScannerStrength MRI scanner strength This variable describes the MRI scanner strength. This is a text field. This variable combines data from CTMRI.MRIScannerStrength and FollowUp.MRIScannerStrength
Imaging.CRFMRISequences MRI sequence(s) This variable describes the MRI sequence. Options are: T1, T2, FLAIR, DWI, GRE, SWI, DTI, MRSI, PWI, Other. Multiple options can be selected. This variable combines data from CTMRI.MRISequences and FollowUp.MRISequences
Imaging.CRFMRITraumAbnormASDH Location: ASDH This variable describes whether or not there is an acute subdural hematoma present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRITraumAbnormASDH and FollowUp.MRITraumAbnormASDH
Imaging.CRFMRITraumAbnormContusion Location: Contusions This variable describes whether or not there is a contusion present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRITraumAbnormContusion and FollowUp.MRITraumAbnormContusion
Imaging.CRFMRITraumAbnormDAI MRI scan results: DAI This variable describes whether or not there is DAI (diffuse axonal injury) present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRITraumAbnormDAI and FollowUp.MRITraumAbnormDAI
Imaging.CRFMRITraumAbnormDAILesionLocBrainstem Location: Brainstem This variable describes whether or not there is a brain stem lesion present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRITraumAbnormDAILesionLocBrainstem and FollowUp.MRITraumAbnormDAILesionLocBrainstem
Imaging.CRFMRITraumAbnormDAILesionLocCorpusCallosum Location: Corpus Callosum This variable describes whether or not there is a corpus callosum lesion present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRITraumAbnormDAILesionLocCorpusCallosum and FollowUp.MRITraumAbnormDAILesionLocCorpusCallosum
Imaging.CRFMRITraumAbnormDAILesionLocDiffuseWhiteMatter Location: Diffuse white matter This variable describes whether or not there is a lesion in diffuse white matter present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRITraumAbnormDAILesionLocDiffuseWhiteMatter and FollowUp.MRITraumAbnormDAILesionLocDiffuseWhiteMatter
Imaging.CRFMRITraumAbnormDAINumLesions Number of lesions This variable describes how many DAI lesions are present on MRI scan (1,2,3,4,>=5). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRITraumAbnormDAINumLesions and FollowUp.MRITraumAbnormDAINumLesions
Imaging.CRFMRITraumAbnormEDH Location: EDH This variable describes whether or not there is an epidural hematoma present on MRI scan (yes, no, unknown). Assessment by investigator and/or physician. This variable combines data from CTMRI.MRITraumAbnormEDH and FollowUp.MRITraumAbnormEDH
Imaging.CRFMRIType MRI type This variable describes the type of MRI scan that has been made. Options are: MRI, MRA This variable combines data from CTMRI.MRIType and FollowUp.MRIType
Imaging.CRFTimePoint Imaging timepoint Imaging.CRFTimepoint = CTMRI.Timepoint + FollowUp.Timepoint Imaging related data from CTMRI table and Followup is combined under Imaging table so that all data is available in a single place. We only combine the ones with a valid IcometrixImageId
Imaging.DicomHeaderURL NIfTI URL DICOM header can add more information to the Nifti image files. The DICOM header is the meta-data part of a DICOM file and is organized as a constant and standardized series of tags. This variable is a URL towards the header file.
Imaging.EpiduralHematoma Epipidural hematoma (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether an epidural hematoma or multiple epidural hematomas are present. More descriptive information (location, volume, number) and advanced information (e.g. arterial versus venous) can be found in the JSON files. Note: Volume was estimated using the AxBxC/2 method. In the JSON files, "descriptive_volume" is the estimated volume of the lesion and can be used for analysis, "descriptive_length", "descriptive_width", "descriptive_max_thickness" are measurements that should not be used in any analysis.
Imaging.ExperimentDate Date of Imaging experiment Experiment Date and time for the entire scan session - retrieved from the DICOM header
Imaging.ExperimentId Scanning Experiment ID S: Experiment id which is generated by the imaging repository (XNAT). B: Is a unique identifier. XNAT is the imaging platform used to collect the data. A: Format of this identifier looks like CTBI_E00000. R: ExperimentId is equal to all the scans within the same experiment: projects/PROJECT_ID/subjects/SUBJECT_ID/experiments/EXPT_ID/scans/SCAN_ID/files/file1.img
Imaging.ExperimentLabel Experiment label S: Experiment label created by the imaging repository. B: Usually looks like: "GUPI_CTx" or "GUPI_MRx" with x specifying the rank of the upload. This label is not a unique identifier. A: Label of the experiment. R: Users are allowed to edit. Label is only unique within one center.
Imaging.ExperimentTime Time of Imaging experiment Experiment Date and time for the entire scan session - retrieved from the DICOM header
Imaging.ExtraaxialHematoma Extraaxial Hematoma This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether an extra-axial hematoma or multiple extra-axial hematomas are present. This term was mostly used for bleedings that were difficult to classify or for bleedings that were evacuated (i.e. after craniectomy). More descriptive information (location, volume, number) and advanced information (e.g. arterial versus venous) can be found in the JSON files. Note: Volume was estimated using the AxBxC/2 method. In the JSON files, "descriptive_volume" is the estimated volume of the lesion and can be used for analysis, "descriptive_length", "descriptive_width", "descriptive_max_thickness" are measurements that should not be used in any analysis.
Imaging.FisherClassification Modified Fisher scale S: A CT grading scale for traumatic Subarachnoid Hemorrhage B: Useful in predicting the occurrence and severity of cerebral vasospasm. Ranges from 1-4 (No tSAH, no IVH (1), no IVH, trace or moderate tSAH (can be in multiple locations) (2), No IVH, full tSAH (3), IVH (4) R: Only available for CT scans. For each patient, the FisherClassification can be found in the Imaging.LesionData variable. For CENTER-TBI, only the older version of Fisher was scored, not the newer "modified" version.
Imaging.Frames Frames B: Scan are acquired in dicom format. A: Number of dicom files that compose the scan.
Imaging.GreenCTGrade Computed tomogrophy grade A CT grading scale for traumatic Subarachnoid Hemorrhage (tSAH). Useful for outcome prediction. Ranges from 1-4, with a subdivision of 3 into "31", "32" and 4 into "41" and "42". (thin tSAH (1), thick tSAH (2), thin tSAH with mass lesion and no MLS (31), thin tSAH with mass lesion and MLS (32), thick tSAH with mass lesion and no MLS (41), thick tSAH with mass lesion and MLS (42). Only available for CT scans. For each patient, the GreenCTgrade can be found in the Imaging.LesionData variable. Could only be filled out when tSAH was present.
Imaging.HelsinkiCTScore Helsinki CT score S: A general CT grading scale B: Useful for outcome prediction. Ranges from -3 to 14. Scoring is done as follows: subdural (+2), intracerebral hematoma (+2), epidural hematoma (-3), mass lesion size >25 cc (+2), IVH (+3), compressed cisterns (+1), obliterated cisterns (+5) R: Only available for CT scans. For each patient, the HelsinkiCTscore can be found in the Imaging.LesionData variable. Empty values for the HelsinkiCTscore stand for a normal CT scan! A score of 0 does not necessarily mean the patient had a normal CT. (e.g. epidural hematoma -3, + IVH = 3 = 0).
Imaging.IntraventricularHemorrhage Intraventricular Hemorrhage (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether intraventricular blood is present. More descriptive information (location) can be found in the JSON files.
Imaging.LesionData Information on lesion(s) as per icometrix (JSON format) This variable contains ALL lesion information as assessed by central review. There are 23 CDEs that have been evaluated for each patient and 6 classifications that have been filled out. For 13 CDEs and all 6 classifications separate variables have been made available. (see "imaging." variables: SkullFracture, Mass lesion, ExtraaxialHematoma, EpiduralHematoma, SubduralHematomaAcute, SubduralHematomaSubacuteChronic, SubduralCollectionMixedDensity, Contusion, TAI, traumaticSubarachnoidHemorrhage, IntraventricularHemorrhage, MidlineShift, CisternalCompression. A derived variable was also created with AnyIntracranTraumaticAbnormality). These 13 CDEs only contain basic information (i.e. lesion is present, absent, indeterminate, uninterpretable, not interpreted).
Imaging.Manufacturer Imaging manufacturer S: Imaging scanner manufacturer. R: Tag (0008,0070) from dicom header available in Imaging.DicomHeaderURL
Imaging.MarshallCTClassification Marshall CT classification A general CT grading scale. Useful for outcome prediction. Ranges from 1 to 6 in our dataset. (No visible pathology on CT (1), Cisterns present, MLS < 5 mm (2), Cisterns compressed or absent, MLS < 5 mm (3), MLS > 5 mm, no mass lesion > 25 cc (4), Evacuated mass lesion (5), Non-evacuated mass lesion (6)) Only available for CT scans. For each patient, the MarshallCTClassification can be found in a Imaging.LesionData variable. For the Marshall CT classification the admission scan was scored. (which is not necessarily the "worst").
Imaging.MassLesion Mass lesion (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether a mass lesion is present. "Mass Lesion" in this case was defined as a total brain lesion volume > 25 cc. Note that this can mean that there is at least one large lesion or multiple co-existing lesions (contusions, subdural hematomas, etc.) that add up to > 25 cc. More information can be found in the JSON files.
Imaging.MidlineShift Midline shift (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether a midline shift of > 5 mm is present. More descriptive information (direction) can be found in the JSON files.
Imaging.MorrisMarshallClassification Morris-Marshall classification S: A CT grading scale for traumatic Subarachnoid Hemorrhage (tSAH) B: Useful for outcome prediction. Ranges from 0-4. (no tSAH (0), trace or moderate tSAH in one location (basal, cortical or tentorial) (1), one location full, or 2 not full (2), two locations full (3), 3 locations or more (4)) R: Only available for CT scans. For each patient, the MorrisMarshallClassification can be found in a Imaging.LesionData variable.
Imaging.NiftiURL NIFTI URL S: Nifti files are converted from original dicom files. B: Nifti is an imaging format.(Neuroimaging Informatics Technology Initiative file format) A: This variable is an URL towards the generated nifti file. R: Open source tool to convert dicom to nifti https://github.com/icometrix/dicom2nifti
Imaging.QCResultsURL QC results URL S: A json file containing MR quality measures. B: All different quality measures that have been applied are being collected in one json file. The comprises at least a protocol check, snr, cnr, head coverage, GM/WM, FA/MD, tensor residuals, ... A: Url to the .json file
Imaging.ReportStatus Report status S: Visual inspection remark B: All MR images have been visually inspected and labeled as approved, rejected or approved with remark. The remark can be found in Imaging.ReportStatusComments R: Imaging.QCResultsURL is being used during this visual inspection. This is the prefered status of the quality of the images.
Imaging.ReportStatusComments Report status (comments, if any) S: Comment on the report status B: All MR images have been visually inspected and labeled as approved, rejected or approved with remark. This variable contains the motivation if the status is rejected or approved with remark.
Imaging.RotterdamCTScore Rotterdam CT score S: A general CT grading scale B: Useful for outcome prediction. Ranges from 1 to 6 in our dataset. Scoring was as follows: IVH or tSAH (+1), Epidural Mass not present (+1), MLS > 5 mm (+1), cisterns compressed (+1), cisterns absent (+1), SUM SCORE = +1 R: Only available for CT scans. For each patient, the RotterdamCTscore can be found in the Imaging.LesionData variable.
Imaging.ScanDetection Detection quality S: Triaging variable for the usablity of a CT scan B: Since all clinical CT scans (head, neck, spine, ...) are uploaded, it is not always clear which scans are usable an which not. In order to know what scans are usable, a variable is defined. This variable gives as an output: UNUSABLE SCANS / USABLE SCANS / DOUBTFULL. R: This triaging is done by computer algorithms and is not 100% water tight.
Imaging.ScanLabel Scan label S: Scan label is a specific identifier for a scan. A: Scan label contains 3 parts: Imaging.ExperimentID Imaging.ExperimentLabel (0020,0011) Series Number (from dicom header) Format: Imaging.ExperimentID_Imaging.ExperimentLabel_SeriesNumber "
Imaging.Scanner Imaging type of scanner used Imaging scanner This information is available from the Imaging.DicomHeaderURL
Imaging.ScanNotes Notes S: Free text remarks from dcm2nii conversion B: This free text variable is used for internal purpose A: R: opensource dcm2nii converter available https://github.com/icometrix/dicom2nifti
Imaging.ScanQuality Scan quality S: This variable is specified by the one who uploaded the images to the imaging repository B: Possible values are usable, questionable, unusable A: Quality of the scan R: Might be very arbitrary and therefor preferable use Imaging.QCResultsURL data and Imaging.ReportStatus as quality reference.
Imaging.ScanType Scan type S: MR Mapping for series description B: Since all centers use different series description, a mapping for T2, T1, FLAIR, T2*, DTI and rs-fMRI is provided. R: For CT, ScanType and Series Description should be the same.
Imaging.SeriesDescription Series description S: Scan Series description retrieved from DICOM header A: Serie Name Given by the image acquisition center. R: DICOM Tag (0008,103E) Series Description
Imaging.SkullFracture Skull fracture (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether a skull fracture or multiple skull fractures are present. More descriptive information (location, number) and advanced information (morphology: e.g. depressed, compound, etc.) can be found in the JSON files.
Imaging.SnapshotURL Imaging mid-slice snapshot in 3 planes S: Mid-slice snapshot from three planes: axial, sagittal and coronal. B: In order to have a quick view on the data, a snapshot of the mid-slice in 3 planes is provided. A: Url to .png screenshot of generated nifti images. R: Screenshot are defaced.
Imaging.SubduralCollectionMixedDensity Subdural Collection Mixed Density (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether one or multiple subdural collections/mixed density hematomas are present. More descriptive information (location, volume, number) and advanced information (e.g. isodensity, hypodensity, acute on chronic, chronic recurrent etc.) can be found in the JSON files. Volume was estimated using the AxBxC/2 method. Note: cfr. epidural and subdural hematoms regarding volumes. Note: In the JSON files length, width and depth of lesions can not be used as metrics in any analysis! Only "descriptive volume" is a valid metric (in cc)
Imaging.SubduralHematomaAcute Subdural Hematoma Acute (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether an acute subdural hematoma or multiple acute subdural hematomas are present. More descriptive information (location, volume, number) and advanced information (homogeneous versus heterogeneous) can be found in the JSON files.Volume was estimated using the AxBxC/2 method, however, small traces of acute subdural blood on the tentorium or interhemispheric were not measured. Note: cfr. epidural: only "descriptive_volume" can be used for analysis. Note: In the JSON files length, width and depth of lesions can not be used as metrics in any analysis! Only "descriptive volume" is a valid metric (in cc)
Imaging.SubduralHematomaSubacuteChronic Subdural Hematoma subacute chronic (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether one or multiple subacute/chronic subdural hematoma(s) are present. More descriptive information (location, volume, number) can be found in the JSON files.Note: Volume was estimated using the AxBxC/2 method. Note: this variable is best considered together with the "SubduralCollectionMixedDensity" variable, as the central reviewer did not have information to time of injury. Many subacute/chronic subdurals were therefore categorised as "mixed density". Note: cfr. epidural and acute subdural hematoma regarding volumes. Note: In the JSON files length, width and depth of lesions can not be used as metrics in any analysis! Only "descriptive volume" is a valid metric (in cc)
Imaging.SubjectGroup Subject stratum (ER, ADM, ICU) S: Subject stratum B: Possible options are: ER, ADMISSION, ICU
Imaging.TAI TAI (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether axonal injury is present. More descriptive information (location, TAI versus DAI) can be found in the JSON files. Note: be aware of the modality you are interested in (i.e. CT or MRI).
Imaging.ThumbnailURL Thumbnail URL S: Screenshot are automatically generated. B: Thumbnails are reduced-size versions of pictures. A: Url to .png screenshot of generated nifti images. R: You can find higher resolution image at the URL provided by Imaging.SnaphshotURL. Screenshot are defaced.
Imaging.Timepoint Timepoint (Imaging) S: Timepoint of the scan acquisition B: For CT scans, possible options are: CT Early, CT Followup, CT Post-op For MR scans, possible options are: MR Early, MR 2 weeks, MR 3 months, MR 6 months, MR 12 months, MR 24 months A: Timepoint of the scan acquisition. R: Date and Time of the experiment is available in Imaging.ExperimentDateTime In order to have the intitial CT reports, download this variable in Neurobot, together with Subject.GUPI, Imaging.ExperimentId and your variables of interest. See steps Imaging.ExperimentId variable.
Imaging.TraumaticSubarachnoidHemorrhage Traumatic Subarachnoid Hemorrhage (present/absent) This variable was assessed by a central review panel, according the TBI-Common Data Elements. This variable indicates whether traumatic subarachnoid blood is present. More descriptive information (location and amount (e.g. trace, moderate, severe)) can be found in the JSON files. * Location can be: cortical, basal, interhemispheric or tentorial.
Imaging.WindowDetectionComment Window detection (comments, if any) Available in case Imaging.WindowDetectionQuality = Window Uncertainty. Imaging.WindowDetection specify if the images are Bone Window, Brain Window or if there is Window Uncertainty. Only available for CT scans.
Imaging.WindowDetectionQuality Window detection quality S: Automated Detection for bone versus brain. B: Possible options: Bone Window, Brain Window, Window Uncertainty R: Only available for CT scans. No brain window scans should be classified as bone window.
Imaging.XsiType Xsi type S: Type of imaging (CT/MR) A: Assess if the scan is CT or MR R: Possible values 'xnat:mrSessionData' and 'xnat:ctSessionData'
InjuryHx.AbdomenPelvicContentsAIS Abdomen/Pelvic Contents AIS AIS score for the Abdomen/Pelvic Contents In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.AbdomenPelvicContentsDesc Abdomen/Pelvic Contents injury description 99 == Other
5 == Retroperitoneal hematoma
4 == Kidney contusion
3 == Perforating abdominal injury
2 == Liver rupture
1 == Spleen rupture
Injury description related to the AIS/ISS score for the Abdomen/Pelvic Contents
InjuryHx.AbdomenPelvicContentsISS ISS score for the abdomen/pelvic content ISS score for the Abdomen/Pelvic Contents
InjuryHx.AbdomenPelvicLumbarRegionAIS AIS score for the abdomen/pelvic lumbar region AIS score for the Abdomen/Pelvic Lumbar region In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.ACEFocalNeuroDeficit Focal neurological deficit (e.g. paresis or dysphasia) 0 == No
1 == Yes
88 == Unknown
On the neurological assessment at presentation overall rating was recorded on Focal neurological deficit (eg paresis or dysphasia)
InjuryHx.ACEFocalNeuroDeficitDysphasia Dysphasia 88 == Unknown
1 == Yes
0 == No
On the neurological assessment at presentation overall rating was recorded on Focal neurological deficit (eg paresis or dysphasia). If this was rate as "yes", details were recorded on whether it was paresis or dysphasia.
InjuryHx.ACEFocalNeuroDeficitOther Other focal neurological deficit On the neurological assessment at presentation overall rating was recorded on Focal neurological deficit (eg paresis or dysphasia) If this was rate as "yes", details were recorded on whether it was paresis or dysphasia or other.
InjuryHx.ACEFocalNeuroDeficitOtherTxt Other focal neurological deficit (please specify) On the neurological assessment at presentation overall rating was recorded on Focal neurological deficit (eg paresis or dysphasia) If this was rate as "yes", details were recorded on whether it was paresis or dysphasia or other, and for other it was specified which one.
InjuryHx.ACEFocalNeuroDeficitParesis Paresis 88 == Unknown
1 == Yes
0 == No
On the neurological assessment at presentation overall rating was recorded on Focal neurological deficit (eg paresis or dysphasia) If this was rate as "yes", details were recorded on whether it was paresis or dysphasia.
InjuryHx.ACEOverallRating How different is the person acting compared to his/her usual self? 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
On the neurological assessment at presentation overall rating was recorded on "How different the person is acting compared to his/her usual self" The rating was on a scale from 1 (normal) to 6 (very different).
InjuryHx.ACEOverallRatingUnknown Overall rating of neurological assessment unknown On the neurological assessment at presentation overall rating was recorded on "How different the person is acting compared to his/her usual self" This variable reflects if the rating was "unknown".
InjuryHx.ACERatedBy Rating performed by 1 == Proxy
2 == Subject
3 == Both proxy and subject
4 == Not done
On the neurological assessment at presentation overall rating was recorded on "How different the person is acting compared to his/her usual self" This variable reflects by whom the rating was performed.
InjuryHx.AlcPriorUseInd Past use: Alcoholic beverages (beer, wine, spirits) (>2/day) 0 == No
1 == Yes
88 == Unknown
On presentation the behavioral history of the patient was recorded. This reflects his past use of alcoholic beverages (beer, wine, spirits).
InjuryHx.AlcUseDur Past use: No. of years of use of alcoholic beverages (beer, wine, spirits) (>2/day) On presentation the behavioral history of the patient was recorded. This reflects the number of years of alcohol use, if past use of alcoholic beverages (beer, wine, spirits) was 'yes'.
InjuryHx.AlcUseLstMoDaysDrankNum Use in the past three months: Alcoholic beverages (beer, wine, spirits> (>2/day) 88 == Unknown
0 == No
1 == Yes
On presentation the behavioral history of the patient was recorded. This reflects his use in the past three months of alcoholic beverages (beer, wine, spirits) (>2/day)
InjuryHx.AUDITCAlcDrnkTypclDayNumScore Average number of alcoholic drinks on a drinking day 1 == 1-2
2 == 3-4
3 == 5-6
4 == 7-9
5 == 10 or more
88 == Unknown
On presentation the behavioral history of the patient was recorded. In case of past use of alcoholic beverages (beer, wine, spirits), this reflects the alcohol frequency: average number of drinks on a "drinking" day
InjuryHx.AUDITCDrnkContainAlcFreqScore Frequency of having a drink containing alcohol 0 == Never
1 == Monthly or less
2 == 2-4 times a month
3 == 2-3 times a week
4 == 4 or more times a week
88 == Unknown
Detailed questions on the use of alcohol are derived from the first 3 questions of the "AUDIT" questionnaire, a screening tool developed by the World Health Organization (WHO) to assess alcohol consumption, drinking behaviors, and alcohol-related problems. The same questions are asked post-injury during full follow-up assessments (including cognitive testing.) This reflects the frequency of having a drink containing alcohol.
InjuryHx.AUDITCMoreThan6AlcDrnkFreqScore Frequency of having six or more alcoholic drinks on one occasion 7 == Weekly
5 == Less than monthly
6 == Monthly
8 == Daily or almost daily
0 == Never
1 == Monthly or less (incorrect please correct)
2 == 2-4 times a month (incorrect please correct)
3 == 2-3 times a week (incorrect please correct)
4 == 4 or more times a week (incorrect please correct)
88 == Unknown
Detailed questions on the use of alcohol are derived from the first 3 questions of the "AUDIT" questionnaire, a screening tool developed by the World Health Organization (WHO) to assess alcohol consumption, drinking behaviors, and alcohol-related problems. The same questions are asked post-injury during full follow-up assessments (including cognitive testing.) This reflects the frequency of having six or more drinks on one occasion.
InjuryHx.BaselineGCSMostReliableAssessmentCondition Conditions of baseline risk assessment 1 == Under sedation
3 == After stopping sedation
0 == No sedation/paralysis
4 == After pharmacological reversal
A baseline risk assessment was performed at the hospital (ER). This reflects the Conditions of assessment for the Most reliable Motor Score for risk assessment.
InjuryHx.BaselineGCSMostReliableAssessmentTime Time of baseline risk assessment 1 == Admission
2 == Post-stabilization
3 == First hospital
4 == Scene of accident
5 == Other
A baseline risk assessment was performed at the hospital (ER). This reflects the Time of assessment for the Most reliable Motor Score for risk assessment.
InjuryHx.BaselineGCSMostReliableMotorScore Most reliable Motor score for baseline risk assessment A baseline risk assessment was performed at the hospital (ER). This reflects the Most reliable baseline Motor score of the GCS as given by sites - for use in prognostic models.
InjuryHx.BaselineGOS6MoDateOfPrognosticEstimate Date of prognostic estimate of 6 month outcome At ER discharge, physician estimate of six month outcome was recorded as a baseline risk assessment: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ER or admission to hospital/ICU". This reflects the Date of prognostic estimate
InjuryHx.BaselineGOS6MoExpectedDeathRisk Expected risk of death at 6 months At ER discharge, physician estimate of six month outcome was recorded as a baseline risk assessment: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ER or admission to hospital/ICU". This reflects the Risk of death in %
InjuryHx.BaselineGOS6MoExpectedOutcome Expected GOS (Glasgow Outcome Scale) at 6 months D == D - Death
V == V - Vegetative State
SD == SD - Severe Disability
MD == MD - Moderate Disability
GR == GR - Good Recovery
At ER discharge, physician estimate of six month outcome was recorded as a baseline risk assessment: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ER or admission to hospital/ICU". This reflects the Expected outcome (GOS)
InjuryHx.BaselineGOS6MoUnfavourableOutcomeRisk Expected risk of unfavourable outcome (D, VS, SD) at 6 months At ER discharge, physician estimate of six month outcome was recorded as a baseline risk assessment: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ER or admission to hospital/ICU". This reflects the Risk of unfavorable outcome (D, VS, SD) in %
InjuryHx.BaselinePhysEstOf6MoOutcomePhysicianQual Qualification of the physician estimating the 6 month outcome 1 == Resident
2 == Junior staff (< 5 years)
3 == Senior staff (>= 5 years)
4 == Head of department
At ER discharge, physician estimate of six month outcome was recorded as a baseline risk assessment: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ER or admission to hospital/ICU". This reflects the qualification of the physician who provided prognostic estimate on ER discharge/admission to hospital/ICU
InjuryHx.BaselinePhysEstOf6MoOutcomePhysicianType Type of the physician estimating the 6 month outcome 1 == ER Physician
2 == Intensive Care
3 == Neurology
4 == Neurosurgery
5 == Traumatology
88 == Unknown
At ER discharge, physician estimate of six month outcome was recorded as a baseline risk assessment: "Given all current available information, what is, in your subjective opinion, the most likely 6-month outcome of this patient? To be based upon information on discharge ER or admission to hospital/ICU". This reflects the type of the physician who provided prognostic estimate on ER discharge/admission to hospital/ICU
InjuryHx.BestOfAbdomenPelvicLumbarISS Abdomen/Pelvic contents, Lumbar Spine ISS AbdomenPelvicLumbar region (Highest AIS of the region)^2 compare AbdomenPelvicContentsAIS, LumbarSpineAIS. This score is taken forward for ISS calculation
InjuryHx.BestOfChestSpineISS Thorax/chest, Thoracic Spine ISS (highest AIS of the region)^2 Compare ThoraxChestAIS, ThoracicSpineAIS and select the highest for ISS calculation
InjuryHx.BestOfExternaISS Externa (Skin) ISS External region (ExternaAIS)^2 select the highest external AIS severity code for ISS calculation.
InjuryHx.BestOfExtremitiesISS Extremities and Pelvic Girdle ISS Extremities region (Highest AIS of the region)^2 compare UpperExtremitiesAIS, LowerExtremitiesAIS, PelvicGirdleAIS select the highest for ISS calculation
InjuryHx.BestOfFaceISS Face ISS Face region (FaceAIS)^2 select the highest facial injury for ISS calculation
InjuryHx.BestOfHeadBrainCervicalISS Head and Neck, Brain and Cervical spine ISS HeadBrainCervical region (Highest AIS of the region)^2 Compare HeadNeckAIS, InjuryHx.BrainInjuryAIS, CervicalSpineAIS select the highest scoring injury in any of these 3 areas for ISS calculation
InjuryHx.BrainInjuryAIS Brain injury AIS AIS score for the Brain Injury In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.BrainInjuryDesc Brain injury description 5 == ASDH
99 == Other
4 == Diffuse Injury
3 == EDH
2 == Contusions
1 == Concussion
Injury description related to the AIS/ISS score for the Brain Injury. Injury description is coded by drop-down menus for each body region
InjuryHx.CannabisCurrentUse Use in the past three month: Cannabis (marijuana, pot, grass, hash, etc.) 0 == No
1 == Yes
88 == Unknown
On presentation the behavioral history of the patient was recorded. This reflects the use in the past three months of Cannabis (marijuana, pot, grass, hash, etc.)
InjuryHx.CannabisPriorUse Past use: Cannabis (marijuana, pot, grass, hash, etc.) 0 == No
1 == Yes
88 == Unknown
On presentation the behavioral history of the patient was recorded. This reflects his past use of Cannabis (marijuana, pot, grass, hash, etc.)
InjuryHx.CannabisPriorUseDuration Past use: No. of years of use of cannabis (marijuana, pot, grass, hash, etc.) On presentation the behavioral history of the patient was recorded. This reflects the number of years of past use of Cannabis if applicable.
InjuryHx.CervicalSpineAIS Cervical Spine AIS AIS score for Cervical Spine region. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.CervicalSpineDesc Cervical Spine injury description 99 == Other
2 == Dislocation
1 == Fracture
Injury description related to the AIS/ISS score for the Cervical Spine region.
InjuryHx.DispER Destination from ER 1 == Discharge home
2 == Discharge other facility
3 == Hospital admission--Ward
5 == Hospital admission--ICU
6 == Hospital admission--OR for immediate surgical procedure
7 == Death
8 == Hospital admission--Other (e.g. observation unit)
88 == Unknown
4 == Hospital admission--Intermediate/high care unit
Destination of the patient at ER discharge.
InjuryHx.DrgSubIllctCurntUseInd Use in the past three months: Other recreational drugs 0 == No
1 == Yes
88 == Unknown
On presentation the behavioral history of the patient was recorded. This reflects the use in the past three months of Other recreational drugs (than Cannabis)
InjuryHx.DrgSubIllctUseCatOther Past use: Other recreational drugs (please specify) On presentation the behavioral history of the patient was recorded. This reflects his past use of which type of drugs.
InjuryHx.DrgSubIllctUseDur Past use: No. of years of use of other recreational drugs On presentation the behavioral history of the patient was recorded. This reflects the number of years of his past use of recreational drugs, if applicable.
InjuryHx.DrgSubPriorIllctUseInd Past use: Other recreational drugs 0 == No
1 == Yes
88 == Unknown
On presentation the behavioral history of the patient was recorded. This reflects his past use of Other recreational drugs (other than Cannabis)
InjuryHx.DrugIllicitCurrentUseOther Use in the past three month: Other recreational drugs (please specify) On presentation the behavioral history of the patient was recorded. This reflects the use in the past three months of which type of drugs
InjuryHx.EDAirway Airway status at ER discharge 1 == No specific treatment
2 == Supplemental oxygen (via nasal tube or mask)
3 == Adjunctive airway (eg. Mayo tube)
4 == Temporary support with bag, valve, mask (eg.ambubag)
5 == Intubation
6 == Mechanical ventilation
88 == Unknown
Records treatment performed in the ER/on admission with regard to Airways. Pre-hospital inteventions are documented at: InjuryHx.PresEmergencyCare
InjuryHx.EDArrDBP Diastolic at ER arrival (first value) Reflects the vital signs at ER arrival: BP (mmHg) --> Diastolic
InjuryHx.EDArrHR Heart Rate at ER arrival (first value) Reflects the vital signs at ER arrival: Heart rate --> Beats per min.
InjuryHx.EDArrivalAirway Airway status at ER arrival 1 == Clear
2 == Obstructed
3 == Adjunctive Airway
4 == Intubated
88 == Unknown
The ABC status on arrival documents the status of Airway, Breathing and Circulation upon arrival to Study Hospital (ER); In addition, administration of supplemental oxygen and spinal immobilization is documented.
InjuryHx.EDArrivalArtpCO2kPa Arterial pCO2 at ER arrival in kPa Reflects the vital signs at ER arrival: Arterial pCO2 --> kPa
InjuryHx.EDArrivalArtpCO2mmhg Arterial pCO2 at ER arrival (first value) Reflects the vital signs at ER arrival: Arterial pCO2 --> mmHg
InjuryHx.EDArrivalArtpCO2unit Unit used for Arterial pCO2 at ER arrival (kPa or mmHg) 1 == kPa
2 == mmHg
Reflects the vital signs at ER arrival: Unit used for Arterial pCO2
InjuryHx.EDArrivalArtpCO2Unknown Arterial pCO2 at ER arrival unknown Reflects the vital signs at ER arrival: Arterial pCO2 --> Unknown
InjuryHx.EDArrivalArtpO2kPa Arterial pO2 at ER arrival in kPa Reflects the vital signs at ER arrival: Arterial pO2 --> kPa
InjuryHx.EDArrivalArtpO2mmhg Arterial pO2 at ER arrival (first value) Reflects the vital signs at ER arrival: Arterial pO2 --> mmHg
InjuryHx.EDArrivalArtpO2unit Unit used for Arterial pO2 at ER arrival (kPa or mmHg) 1 == kPa
2 == mmHg
Reflects the vital signs at ER arrival: Unit used for Arterial pO2
InjuryHx.EDArrivalArtpO2Unknown Arterial pO2 at ER arrival unknown Reflects the vital signs at ER arrival: Arterial pO2 --> Unknown
InjuryHx.EDArrivalBaseExcess Base Excess at ER arrival (first value) Reflects the vital signs at ER arrival: Base excess --> mEq/l
InjuryHx.EDArrivalBaseExcessUnit Unit used for Base excess at ER arrival (mEq/l or other) 99 == Other
1 == mEq/l
Reflects the vital signs at ER arrival: the unit used for Base excess
InjuryHx.EDArrivalBaseExcessUnitSpecify Which other (than standard) unit used for Base excess at ER arrival Reflects the vital signs at ER arrival: specifies if another unit was used than the standard unit for Base excess
InjuryHx.EDArrivalBaseExcessUnknown Base excess at ER arrival unknown Reflects the vital signs at ER arrival: Base excess --> Unknown
InjuryHx.EDArrivalBloodGasDone First arterial blood gas done at ER arrival 0 == No
1 == Yes
Reflects the vital signs at ER arrival: reflects if First arterial blood gas was done Arterial blood gas analysis is not required for all subjects. Performed on clinical indication; will generally be restricted to subjects with more severe injuries
InjuryHx.EDArrivalBloodPressureUnknown Blood Pressure at ER arrival unknown 88 == Unknown Reflects the vital signs at ER arrival: BP (mmHg) --> Unknown
InjuryHx.EDArrivalBMI BMI at ER arrival (based on inches and pounds) BMI using height in inches (EDArrivalHeightInches) and weight in pounds (EDArrivalBodyWeightLbs) BMI=((weight/(height*height)) * 704.5469
InjuryHx.EDArrivalBMIKgCm BMI (Body Mass Index) at ER arrival BMI using height in cm (EDArrivalHeightCm) and weight (EDArrivalBodyWeightKg) BMI= (Weight/(Height*Height))) * 10000
InjuryHx.EDArrivalBodyWeightKg Body weight at ER arrival Body weight in KG at ER arrival
InjuryHx.EDArrivalBodyWeightLbs Body weight at ER arrival in Lbs Body weight in LBS at ER arrival
InjuryHx.EDArrivalBodyWeightMeasured Reliability of the body weight reported at ER arrival 1 == Estimated
2 == Self reported
3 == Measured
4 == Proxy reported
88 == Unknown
Provides an indication of accuracy of reported body weight at ER arrival
InjuryHx.EDArrivalBodyWeightUnit Unit used for body weight at ER arrival (kg or lbs) 1 == kg
2 == lbs
Unit used for Body weight at ER arrival
InjuryHx.EDArrivalBreathing Breathing status at ER arrival 1 == Spontaneous, adequate
2 == Spontaneous, insufficient
3 == Manual support with bag, valve, mask
4 == Mechanical ventilation
88 == Unknown
The ABC status on arrival documents the status of Airway, Breathing and Circulation upon arrival to Study Hospital (ER); In addition, administration of supplemental oxygen and spinal immobilization is documented.
InjuryHx.EDArrivalCirculation Circulation status at ER arrival 0 == No specific therapy
1 == IV Fluids
2 == Vasopressors
3 == CPR
88 == Unknown
The ABC status on arrival documents the status of Airway, Breathing and Circulation upon arrival to Study Hospital (ER); In addition, administration of supplemental oxygen and spinal immobilization is documented.
InjuryHx.EDArrivalFiO2 FiO2 at ER arrival (first value) Reflects the vital signs at ER arrival: FiO2 (in %) Information on FiO2 (Fraction of Inspired oxygen) at time of arterial blood gas sampling is requested in order to be able to calculate PaO2/FiO2 as measure of severity of hypoxaemia; dependent on altitude; at sea-level, normal values are > 500 mmHg
InjuryHx.EDArrivalFiO2Unknown FiO2 at ER arrival Reflects the vital signs at ER arrival: FiO2 (in %) = unknown
InjuryHx.EDArrivalHeartRateUnknown Heart rate at ER arrival Unknown Reflects the vital signs at ER arrival: Heart rate --> Unknown
InjuryHx.EDArrivalHeightCm Height Reflects Height in cm at ER arrival
InjuryHx.EDArrivalHeightInches Height in inches at ER arrival Reflects Height in inches at ER arrival
InjuryHx.EDArrivalHeightMeasured Reliability of height reported 1 == Estimated
2 == Self reported
3 == Measured
4 == Proxy reported
88 == Unknown
Provides an indication of accuracy of reported height at ER arrival
InjuryHx.EDArrivalHeightUnit Unit used for height at ER arrival (cm or inches) 1 == cm
2 == inch
Reflects unit used for Height at arrival
InjuryHx.EDArrivalLactate Lactate at ER arrival (first value) Reflects the vital signs at ER arrival: Lactate --> mEq/l
InjuryHx.EDArrivalLactateUnit Unit used for lactate at ER arrival (if not standard unit) 99 == Other
1 == mEq/l
Reflects if for "lactate" as vital signs at ER arrival another unit was used than the standard.
InjuryHx.EDArrivalLactateUnitSpecify Which other unit used for lactate at ER arrival (if not standard unit) Reflects the vital signs at ER arrival: Specifies for Lactate the unit used if another unit than the standard was used
InjuryHx.EDArrivalLactateUnknown Lactate at ER arrival Unknown Reflects the vital signs at ER arrival: Lactate --> Unknown
InjuryHx.EDArrivalOxygenSatUnknown Oxygen saturation at ER arrival Unknown Reflects the vital signs at ER arrival: Oxygen saturation --> Unknown
InjuryHx.EDArrivalpH pH at ER arrival (first value) Reflects the vital signs at ER arrival: pH
InjuryHx.EDArrivalpHUnknown pH at ER arrival Unknown Reflects the vital signs at ER arrival: pH --> Unknown
InjuryHx.EDArrivalRespRateUnknown Respiratory rate at ER arrival Onknown 1 == Spontaneous
2 == Ventilated
88 == Unknown
Reflects the vital signs at ER arrival: Respiratory rate --> Unknown
InjuryHx.EDArrivalSpinalImmob Spinal Immobilization at ER arrival 0 == No
1 == Yes
88 == Unknown
The ABC status on arrival documents the status of Airway, Breathing and Circulation upon arrival to Study Hospital (ER); In addition, administration of supplemental oxygen and spinal immobilization is documented.
InjuryHx.EDArrivalSupplementalOxygen Supplemental Oxygen at ER arrival 0 == No
1 == Yes
88 == Unknown
The ABC status on arrival documents the status of Airway, Breathing and Circulation upon arrival to Study Hospital (ER); In addition, administration of supplemental oxygen and spinal immobilization is documented.
InjuryHx.EDArrivalTemperatureUnknown Temperature at ER arrival Unknown The ABC status on arrival documents the status of Airway, Breathing and Circulation upon arrival to Study Hospital (ER); In addition, administration of supplemental oxygen and spinal immobilization is documented.
InjuryHx.EDArrPupilLftEyeMeasr Left eye pupil size at ER arrival 1 == 1
10 == 10
9 == 9
8 == 8
7 == 7
6 == 6
5 == 5
4 == 4
3 == 3
2 == 2
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the size of the left eye pupil for the assessment at Arrival to ER of the study hospital.
InjuryHx.EDArrPupilLftEyeMeasrUnkUnt Left pupil at ER arrival Untestable/Unknown 88 == Unknown
66 == Untestable
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects if GCS was Untestable/Unknown for the assessment at Arrival to ER of the study hospital.
InjuryHx.EDArrPupilReactivityLghtLftEyeReslt Left eye pupil reactivity at ER arrival 3 == - (Negative)
2 == + (Sluggish)
1 == + (Brisk)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the reactivity of the left eye pupil for the assessment at Arrival to ER of the study hospital.
InjuryHx.EDArrPupilReactivityLghtRtEyeReslt Right eye pupil reactivity at ER arrival 3 == - (Negative)
2 == + (Sluggish)
1 == + (Brisk)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the reactivity of the right eye pupil for the assessment at Arrival to ER of the study hospital.
InjuryHx.EDArrPupilRtEyeMeasr Right eye pupil size at ER arrival 3 == 3
2 == 2
1 == 1
10 == 10
9 == 9
8 == 8
7 == 7
6 == 6
5 == 5
4 == 4
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the size of the right eye pupil for the assessment at Arrival to ER of the study hospital.
InjuryHx.EDArrPupilRtEyeMeasrUnkUnt Right pupil at ER arrival Untestable/Unknown 88 == Unknown
66 == Untestable
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects if GCS was Untestable/Unknown for the assessment at Arrival to ER of the study hospital.
InjuryHx.EDArrPupilSymmetry Pupil symmetry at ER arrival 3 == Unequal L>R
2 == Unequal R>L
1 == Equal
66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the Pupil symmetry for the assessment at Arrival to ER of the study hospital.
InjuryHx.EDArrRespRate Respiratory Rate at ER arrival (first value) Reflects the vital signs at ER arrival: Respiratory rate --> cycles per min
InjuryHx.EDArrSBP Systolic at ER arrival (first value) Reflects the vital signs at ER arrival: BP (mmHg) --> Systolic
InjuryHx.EDArrSpO2 Oxygen saturation at ER arrival (first value) Reflects the vital signs at ER arrival: Oxygen saturation (in %)
InjuryHx.EDArrTempCelsius Body temperature at ER arrival (first value) Reflects the vital signs at ER arrival: Temperature --> Celcius
InjuryHx.EDArrTempFahrenheit Temperature at ER arrival in Fahrenheit Reflects the vital signs at ER arrival: Temperature --> Fahrenheit
InjuryHx.EDArrTempUnit Unit used for temperature at ER arrival (C° or F) 1 == C
2 == F
Reflects the unit used for temperature measurement as vital signs at ER arrival
InjuryHx.EDBloodGasConditions Conditions of ABG (Arterial Blood Gas) test at ER arrival 1 == Pre-intubation, room air
2 == Pre-intubation, +O2
3 == Post-intubation, not ventilated
4 == Post-intubation, ventilated
Reflects the vital signs at ER arrival: Conditions for First arterial blood gas done (if applicable)
InjuryHx.EDBloodGasDate Date of first ABG (Arterial Blood Gas) test at ER arrival Reflects the vital signs at ER arrival: date for First arterial blood gas done (if applicable)
InjuryHx.EDBloodGasTime Time of first ABG (Arterial Blood Gas) test at ER arrival Reflects the vital signs at ER arrival: time for First arterial blood gas done (if applicable)
InjuryHx.EDBloodTrans Blood transfusion 1 == Yes
0 == No
88 == Unknown
Reflects of blood transfusion was done in the ER of the study hospital
InjuryHx.EDCircCPR Circulation: CPR Records treatment performed in the ER/on admission with regard to Circulation: CPR. Pre-hospital inteventions are documented at: InjuryHx.PresEmergencyCare
InjuryHx.EDCircIV Circulation: IV fluids Records treatment performed in the ER/on admission with regard to Circulation: IV fluids. Pre-hospital inteventions are documented at: InjuryHx.PresEmergencyCare
InjuryHx.EDCircNone Circulation: No specific treatment Records treatment performed in the ER/on admission with regard to Circulation: no specific treatment Pre-hospital inteventions are documented at: InjuryHx.PresCirculationTreatmentNone
InjuryHx.EDCircUnknown Circulation treatment at ER arrival Unknown Records treatment performed in the ER/on admission with regard to Circulation: unknown. Pre-hospital inteventions are documented at: InjuryHx.PresEmergencyCare
InjuryHx.EDCircVaso Circulation: Vasopressors Records treatment performed in the ER/on admission with regard to Circulation: vasopressors. Pre-hospital inteventions are documented at: InjuryHx.PresEmergencyCare
InjuryHx.EDCoagulopathyType1 (1) Type of coagulopathy 15 == Vitamin K (Konakion)
1 == Packed red blood cell concentrates (pRBCs)
2 == Fresh whole blood
3 == Fresh frozen plasma (FFP)
4 == Freeze dried plasma / lypholized plasma
5 == Platelet concentrates
6 == PCC (prothrombin complex concentrates)
7 == Fibrinogen concentrate
8 == Albumin
9 == Recombinant factor FVIIa
10 == Tranexamic acid (TXA)
11 == Cryoprecipitate
12 == Desmopression (DDAVP)
13 == Factor XIII
14 == Calcium
Reflects the type of transfusion or coagulopathy treatment given in the ER of the study hospital (if applicable)
InjuryHx.EDCoagulopathyType2 (2) Type of coagulopathy 15 == Vitamin K (Konakion)
1 == Packed red blood cell concentrates (pRBCs)
2 == Fresh whole blood
3 == Fresh frozen plasma (FFP)
4 == Freeze dried plasma / lypholized plasma
5 == Platelet concentrates
6 == PCC (prothrombin complex concentrates)
7 == Fibrinogen concentrate
8 == Albumin
9 == Recombinant factor FVIIa
10 == Tranexamic acid (TXA)
11 == Cryoprecipitate
12 == Desmopression (DDAVP)
13 == Factor XIII
14 == Calcium
Reflects the type of transfusion or coagulopathy treatment given in the ER of the study hospital (if applicable)
InjuryHx.EDCoagulopathyType3 (3) Type of coagulopathy 15 == Vitamin K (Konakion)
1 == Packed red blood cell concentrates (pRBCs)
2 == Fresh whole blood
3 == Fresh frozen plasma (FFP)
4 == Freeze dried plasma / lypholized plasma
5 == Platelet concentrates
6 == PCC (prothrombin complex concentrates)
7 == Fibrinogen concentrate
8 == Albumin
9 == Recombinant factor FVIIa
10 == Tranexamic acid (TXA)
11 == Cryoprecipitate
12 == Desmopression (DDAVP)
13 == Factor XIII
14 == Calcium
Reflects the type of transfusion or coagulopathy treatment given in the ER of the study hospital (if applicable)
InjuryHx.EDCoagulopathyType4 (4) Type of coagulopathy 15 == Vitamin K (Konakion)
1 == Packed red blood cell concentrates (pRBCs)
2 == Fresh whole blood
3 == Fresh frozen plasma (FFP)
4 == Freeze dried plasma / lypholized plasma
5 == Platelet concentrates
6 == PCC (prothrombin complex concentrates)
7 == Fibrinogen concentrate
8 == Albumin
9 == Recombinant factor FVIIa
10 == Tranexamic acid (TXA)
11 == Cryoprecipitate
12 == Desmopression (DDAVP)
13 == Factor XIII
14 == Calcium
Reflects the type of transfusion or coagulopathy treatment given in the ER of the study hospital (if applicable)
InjuryHx.EDCoagulopathyVolume1 (1) Volume Reflects the volume of transfusion or coagulopathy treatment given in the ER of the study hospital (if applicable)
InjuryHx.EDCoagulopathyVolume2 (2) Volume Reflects the volume of transfusion or coagulopathy treatment given in the ER of the study hospital (if applicable)
InjuryHx.EDCoagulopathyVolume3 (3) Volume Reflects the volume of transfusion or coagulopathy treatment given in the ER of the study hospital (if applicable)
InjuryHx.EDCoagulopathyVolume4 (4) Volume Reflects the volume of transfusion or coagulopathy treatment given in the ER of the study hospital (if applicable)
InjuryHx.EDCompEventHypothermia Hypothermia (core temp < 35 degree Celsius) 88 == Unknown
0 == No
1 == Definite
2 == Suspect
Second Insults reported here relate to the pre-hospital and ER phase. Hypothermia is defined as a documented core temperature of < 35 C.
InjuryHx.EDComplEventCardArr Cardiac Arrest 0 == No
1 == Yes
Second Insults reported here relate to the pre-hospital and ER phase: Cardiac Arrest
InjuryHx.EDComplEventHypotension Hypotensive Episode (Systolic BP < 90 mmHg in adults) 0 == No
2 == Suspect
1 == Definite
88 == Unknown
Second Insults reported here relate to the pre-hospital and ER phase. Definite hypotension is defined as a documented systolic BP < 90 mm Hg (adults); "Suspected" was scored if the patient did not have a documented blood pressure, but was reported to be in shock or have an absent brachial pulse (not related to injury of the extremity)
InjuryHx.EDComplEventHypoxia Hypoxic Episode (PaO2 < 8 kPa (60 mmHg)/SaO2 < 90%) 0 == No
2 == Suspect
1 == Definite
88 == Unknown
Second Insults reported here relate to the pre-hospital and ER phase. Definite hypoxia is defined as a documented PaO2 <8 kPa (60 mm Hg) and/or SaO2<90%; "Suspected" was scored if the patient did not have documented hypoxia by PaO2 or SaO2, but there was a clinical suspicion , as evidenced by for example cyanosis, apnoea or respiratory distress
InjuryHx.EDComplEventSeizures Seizures 0 == No
1 == Partial/Focal
2 == Generalized
3 == Status epilepticus
88 == Unknown
Second Insults reported here relate to the pre-hospital and ER phase: seizures
InjuryHx.EDCorrCoagulopathy Transfusions and treatment of coagulopathy 1 == Yes
0 == No
88 == Unknown
Documents blood transfusions and treatment of coagulopathy in the acute phase at presentation.
InjuryHx.EDDischDate Date of ER discharge Documents the date of discharge from the ER/admission to Ward/ICU
InjuryHx.EDDischPupilLftEyeMeasr Left eye pupil size poststabilization 5 == 5
4 == 4
3 == 3
2 == 2
1 == 1
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the size of the left eye pupil for the assessment POST­-STABILIZATION.
InjuryHx.EDDischPupilLftEyeMeasrUnkUnt Left pupil at ER discharge Untestable/Unknown 88 == Unknown
66 == Untestable
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects is left eye pupil was Untestable/Unknown for the assessment POST­-STABILIZATION.
InjuryHx.EDDischPupilReactivityLghtLftEyeReslt Left eye pupil reactivity poststabilization 1 == + (Brisk)
2 == + (Sluggish)
3 == - (Negative)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the reactivity of the left eye pupil for the assessment POST­-STABILIZATION.
InjuryHx.EDDischPupilReactivityLghtRtEyeReslt Right eye pupil reactivity poststabilization 1 == + (Brisk)
2 == + (Sluggish)
3 == - (Negative)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the reactivity of the right eye pupil for the assessment POST­-STABILIZATION.
InjuryHx.EDDischPupilRtEyeMeasr Right eye pupil size poststabilization 1 == 1
2 == 2
3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the size of the right eye pupil for the assessment POST­-STABILIZATION.
InjuryHx.EDDischPupilRtEyeMeasrUnkUnt Right pupil at ER discharge Untestable/Unknown 88 == Unknown
66 == Untestable
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects if right eye pupil was Untestable/Unknown for the assessment POST­-STABILIZATION.
InjuryHx.EDDischPupilSymmetry Pupil symmetry post-stabilization 3 == Unequal L>R
2 == Unequal R>L
1 == Equal
66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects pupil symmetry for the assessment POST­-STABILIZATION.
InjuryHx.EDDischTime Time of ER discharge Documents the time of discharge from the ER/admission to Ward/ICU
InjuryHx.EDICPMonitoring ICP monitoring scheduled at ER discharge 0 == No
1 == Yes
88 == Unknown
Scheduled for ICP monitoring; e.g. may not accurately reflect if ICP monitoring was indeed performed
InjuryHx.EDIVAlbumin IV fluids specifics: Albumin Records treatment performed in the ER/on admission with regard to Circulation: IV fluids --> Albumin
InjuryHx.EDIVBlood IV fluids specifics: Blood Records treatment performed in the ER/on admission with regard to Circulation: IV fluids --> Blood
InjuryHx.EDIVColloids IV fluids specifics: Colloids Records treatment performed in the ER/on admission with regard to Circulation: IV fluids --> Colloids
InjuryHx.EDIVCrystalloids IV fluids specifics: Crystalloids Records treatment performed in the ER/on admission with regard to Circulation: IV fluids --> Crystalloids
InjuryHx.EDIVMannitol IV fluids specifics: Mannitol Records treatment performed in the ER/on admission with regard to Circulation: IV fluids --> Mannitol
InjuryHx.EDIVSaline IV fluids specifics: Hypertonic saline Records treatment performed in the ER/on admission with regard to Circulation: IV fluids --> Hypertonic saline
InjuryHx.EDSecondInsultsNeuroWorse Neuroworsening 0 == No
1 == Yes
88 == Unknown
The importance of Neuroworsening was first described by Morris and Marshall. The occurrence of neuroworsening is related to poorer outcome in subjects with moderate to severe TBI. Neuroworsening is defined as 1) a decrease in GCS motor score of 2 or more points; 2) a new loss of pupillary reactivity or development of pupillary assymmetry >= 2mm; 3) deterioration in neurological or CT status sufficient to warrant immediate medical or surgical intervention
InjuryHx.EDSecondInsultsNeuroWorseYes Neuroworsening (please describe) 1 == Decrease in motor score >= 2 points
2 == Development of pupillary abnormalities
3 == Other neurological and/or CT deterioration
This variable provides a specification of the type of neuroworsening if it occurs.
InjuryHx.EDSecondInsultsPreAdmisCourse Pre-admission course 0 == Deterioration
1 == Stable
2 == Improving
88 == Unknown
The pre-admission course should only be considered an intracranial second insult in case of Deterioration. The nature of deterioration will in most cases be further detailed under the variable "Neuroworsening".
InjuryHx.EDSpinalImmob Spinal immobilization at ER discharge 0 == No
1 == Yes
88 == Unknown
Records treatment performed in the ER/on admission with regard to Spinal immobilization. Pre-hospital inteventions are documented at: InjuryHx.PresEmergencyCare
InjuryHx.EmergSurgInterventionsExtraCran Emergency extracranial surgical intervention scheduled at ER discharge 0 == No
1 == Yes
88 == Unknown
Documents emergency extracranial surgery performed in study hospital. Procedures performed in "first" hospital (in case of secondary referral) are documented at: InjuryHx.PresERextracranialSurg
InjuryHx.EmergSurgInterventionsExtraCranYes Emergency extracranial surgical intervention scheduled at ER discharge (please specify) 3 == Extraperitoneal pelvic packing
4 == External fixation limb
2 == Damage control laparotomy
1 == Damage control thoracotomy
5 == Cranio-maxillo-facial reconstruction
99 == Other
Documents emergency extracranial surgery performed in study hospital. Procedures performed in "first" hospital (in case of secondary referral) are documented at: InjuryHx.PresERextracranialSurg
InjuryHx.EmergSurgInterventionsExtraCranYesOther Other emergency extracranial surgical intervention scheduled at ER discharge (please specify) Documents emergency extracranial surgery performed in study hospital. Procedures performed in "first" hospital (in case of secondary referral) are documented at: InjuryHx.PresERextracranialSurg
InjuryHx.EmergSurgInterventionsIntraCran Emergency intracranial surgical intervention scheduled at ER discharge 0 == No
1 == Yes
88 == Unknown
Documents emergency intracranial surgery performed in study hospital. Procedures performed in "first" hospital (in case of secondary referral) are documented at: InjuryHx.PresERIntracranialSurg
InjuryHx.EmergSurgInterventionsIntraCranYes Emergency intracranial surgical intervention scheduled at ER discharge (please specify) 1 == Craniotomy for haematoma/contusion
2 == Decompressive Craniectomy
3 == Depressed skull fracture
99 == Other intracranial procedure
Documents emergency intracranial surgery performed in study hospital. Procedures performed in "first" hospital (in case of secondary referral) are documented at: InjuryHx.PresERIntracranialSurg
InjuryHx.EmerSurgIntraCranSurviveNoSurg Emergency intracranial surgical interventions scheduled at ER discharge: The short term survival chances of the patients if I DO NOT operate will be "InjuryHx.EmerSurgIntraCranSurviveNoSurg" and "InjuryHx.EmerSurgIntraCranSurviveYesSurg" These 2 variables aim to capture information on the surgeon's expectations, eg if the surgeon considers a realistic expectation of benefit, or performs the surgery as a "last resort" in a likely hopeless case. 'The short term survival chances of the patients if I DO NOT operate will be (in %)'
InjuryHx.EmerSurgIntraCranSurviveYesSurg Emergency intracranial surgical interventions scheduled at ER discharge: The short term survival chances of the patients if I DO operate will be "InjuryHx.EmerSurgIntraCranSurviveNoSurg" and "InjuryHx.EmerSurgIntraCranSurviveYesSurg" These 2 variables aim to capture information on the surgeon's expectations, eg if the surgeon considers a realistic expectation of benefit, or performs the surgery as a "last resort" in a likely hopeless case. 'The short term survival chances of the patients if I DO operate will be (in %)'
InjuryHx.ERDestICDCodes1 (1) ICD code at ER discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes10 Up to 16 fields to enter ICD codes at ER discharge (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes11 Up to 16 fields to enter ICD codes at ER discharge (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes12 Up to 16 fields to enter ICD codes at ER discharge (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes13 Up to 16 fields to enter ICD codes at ER discharge (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes14 Up to 16 fields to enter ICD codes at ER discharge (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes15 Up to 16 fields to enter ICD codes at ER discharge (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes16 Up to 16 fields to enter ICD codes at ER discharge (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes2 (2) ICD code at ER discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes3 (3) ICD code at ER discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes4 (4) ICD code at ER discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes5 (5) ICD code at ER discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes6 (6) ICD code at ER discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes7 (7) ICD code at ER discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes8 (8) ICD code at ER discharge Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodes9 Up to 16 fields to enter ICD codes at ER discharge (of hospital administration) Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDestICDCodesVersion ICD code version at ER discharge 9 == ICD-9
10 == ICD-10
Reflects the version used: ICD-9 or ICD-10. Up to 16 fields available to enter diagnosis as recorded by hospital administration according to ICD codes; applicable to patients discharged directly from the ER. For patients admitted to hospital or ICU, ICD codes are documented in: Hospital.ICDCode1 and Hospital.ICUDischargeICDCode1
InjuryHx.ERDischHomeSchedApptOutpatient Any out-patient visit scheduled following ER discharge 0 == No
1 == Yes
88 == Unknown
Reflects the scheduled appointments for patients discharged from ER to home or to another facility. The scheduled appointments gives details on Out­patient visit, Referred to general practitioner, study protocol follow up and MR study planned.
InjuryHx.ERDischHomeSchedApptOutpatientDate Date of the out-patient visit following ER discharge Reflects the scheduled appointments for patients discharged from ER to home or to another facility. The scheduled appointments gives details on Out­patient visit, Referred to general practitioner, study protocol follow up and MR study planned.
InjuryHx.ERDischHomeSchedApptReferToGP Referred to general practitioner 0 == No
1 == Yes
88 == Unknown
Reflects the scheduled appointments for patients discharged from ER to home or to another facility. The scheduled appointments gives details on Out­patient visit, Referred to general practitioner, study protocol follow up and MR study planned.
InjuryHx.ERDischHomeSchedApptStudyProtoFU Study protocol follow-up 0 == No
1 == Yes
88 == Unknown
Reflects the scheduled appointments for patients discharged from ER to home or to another facility. The scheduled appointments gives details on Out­patient visit, Referred to general practitioner, study protocol follow up and MR study planned.
InjuryHx.ERDischHomeTypeOfCarePlanned Type of care planned following ER discharge 0 == None
1 == Symptomatic treatment or/and advice for the next 24/48h
2 == Systematic follow-up visit by GP
3 == Systematic follow-up visit by specialist practitioner
4 == Oral information on TBI, its possible late consequences, and where to consult in case of difficulties
5 == Written information on TBI, its possible late consequences, and where to consult in case of difficulties
Reflects the type of care planned for patients discharged from ER to home or to another facility.
InjuryHx.ERDischMotivForDestChoice Motivation for the choice of destination from ER 1 == Normal CT
2 == Medical necessity
3 == Social circumstances
4 == No (ICU-) beds available
5 == Requiring specialized facilities
88 == Unknown
99 == Other
WHY Question: documents main reason for choice of destination at ER discharge.
InjuryHx.ERDischMotivForDestChoiceOther Other destination from ER (please specify) WHY Question: documents main reason for choice of destination after ER discharge --> Other
InjuryHx.ExternaAIS Externa (skin) AIS AIS score for the Externa (skin) region. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.ExternaDesc Externa (skin) injury description 1 == No values yet Injury description related to the AIS/ISS score for the Externa (skin) region.
InjuryHx.FaceAIS Face AIS AIS score for the Face (incl.maxillofacial) region In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.FaceDesc Face injury description 99 == Other
5 == Zygomatic arch fracture
4 == Orbital fracture
2 == Maxillo-facial fracture le Fort II
3 == Maxillo-facial fracture le Fort III
1 == Maxillo-facial fracture le Fort I
Injury description related to the AIS/ISS score for the Face (incl.maxillofacial) region
InjuryHx.FirstHospAssmtCondition GCS assessment conditions at First Hospital 0 == No sedation or paralysis
2 == Paralyzed
1 == Sedated
3 == Temporary stop of sedation/paralysis
4 == Reversal of sedation/paralysis
5 == Active reversal (pharmacologic) of sedation/paralysis
99 == Other
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This Describes the condition under which the GCS was assessed at First Hospital.
InjuryHx.GcsEDArrAssmtCond GCS assessment conditions at ER arrival 99 == Other
0 == No sedation or paralysis
2 == Paralyzed
1 == Sedated
3 == Temporary stop of sedation/paralysis
4 == Reversal of sedation/paralysis
5 == Active reversal (pharmacologic) of sedation/paralysis
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the condition under which the GCS was assessed at Arrival to ER of the study hospital.
InjuryHx.GCSEDArrEyes Eye opening (E) response at ER arrival 4 == 4-Spontaneously
3 == 3-To speech
2 == 2-To pain
1 == 1-None
S == Untestable (swollen)
UN == Unknown
O == Untestable (other)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the GCS Eye opening at Arrival to ER of study hospital.
InjuryHx.GCSEDArrMotor Motor (M) response at ER arrival 6 == 6-Obeys command
5 == 5-Localizes to pain
4 == 4-Normal flexion/withdrawal
3 == 3-Abnormal flexion
2 == 2-Abnormal extension
1 == 1-None
P == Untestable (Deep sedation/paralyzed)
O == Untestable (Other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the GCS Motor score at Arrival to ER of study hospital.
InjuryHx.GcsEDArrNotDone GCS at arrival of study hospital Not done 77 == Not done / Results not available Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This indicates that GCS at Arrival to Study hospital was not done.
InjuryHx.GCSEDArrScore GCS score at ER arrival Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This is a Calculated score for Arrival at ER of study hospital: GCSEDArrEyes + GCSEDArrMotor + GCSEDArrVerbal. If one or more of these is Untestable or unknown then = "No Sum"
InjuryHx.GcsEDArrScoreDate Date of GCS assessment at ER arrival Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the date of assessment at Arrival to ER of the study hospital.
InjuryHx.GcsEDArrScoreTime Time of GCS assessment at ER arrival Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the time of assessment at Arrival to ER of the study hospital.
InjuryHx.GCSEDArrVerbal Verbal (V) response at ER arrival 5 == 5-Oriented
4 == 4-Confused
3 == 3-Inappropriate words
2 == 2-Incomprehensible sound
1 == 1-None
T == Untestable (Tracheotomy/endotracheal tube)
O == Untestable (Other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects GCS Verbal score at Arrival to ER of study hospital
InjuryHx.GcsEDDischAssmtCond GCS assessment conditions poststabilization 99 == Other
0 == No Sedation or Paralysis
2 == Paralyzed
1 == Sedated
3 == Temporary stop of sedation/paralysis
4 == Reversal of sedation/paralysis
5 == Active reversal (pharmacologic) of sedation/paralysis
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the condition under which the GCS was assessed POST-STABILIZATION.
InjuryHx.GCSEDDischEyes Eye opening (E) response poststabilization 4 == 4-Spontaneously
3 == 3-To speech
2 == 2-To pain
1 == 1-None
O == Untestable (other)
UN == Unknown
S == Untestable (swollen)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects GCS eye opening for the assessment POST­-STABILIZATION.
InjuryHx.GCSEDDischMotor Motor (M) response poststabilization 6 == 6-Obeys command
5 == 5-Localizes to pain
4 == 4-Normal flexion/withdrawal
3 == 3-Abnormal flexion
2 == 2-Abnormal extension
1 == 1-None
P == Untestable (Deep sedation/paralyzed)
UN == Unknown
O == Untestable (Other)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects GCS Motor score for the assessment POST­-STABILIZATION.
InjuryHx.GcsEDDischNotDone GCS at ER discharge Not done 77 == Not done / Results not available Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This indicates that GCS at Post-stabilization was not done.
InjuryHx.GCSEDDischScore GCS score poststabilization Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This is the Calculated score for the POST-STABILIZATION assessment: GCSEDDischEyes + GCSEDDischMotor + GCSEDDischVerbal. If one or more of these is Untestable or unknown then = "No Sum"
InjuryHx.GcsEDDischScoreDate Date of GCS assessment poststabilization Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects Date for the assessment POST­-STABILIZATION.
InjuryHx.GcsEDDischScoreTime Time of GCS assessment poststabilization Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the Time for the assessment POST­-STABILIZATION.
InjuryHx.GCSEDDischVerbal Verbal (V) response poststabilization 5 == 5-Oriented
4 == 4-Confused
3 == 3-Inappropriate words
2 == 2-Incomprehensible sound
1 == 1-None
T == Untestable (Tracheotomy/endotracheal tube)
O == Untestable (Other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects GCS Verbal score for the assessment POST­-STABILIZATION.
InjuryHx.GCSFirstHospEyes Eye opening (E) response at First Hospital 1 == 1-None
2 == 2-To pain
3 == 3-To speech
4 == 4-Spontaneously
S == Untestable (swollen)
O == Untestable (other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects GCS eye opening for the assessment at First Hospital.
InjuryHx.GCSFirstHospMotor Motor (M) response at First Hospital 1 == 1-None
O == Untestable (Other)
2 == 2-Abnormal extension
3 == 3-Abnormal flexion
4 == 4-Normal flexion/withdrawal
5 == 5-Localizes to pain
6 == 6-Obeys command
P == Untestable (Deep sedation/paralyzed)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects GCS Motor score for the assessment at First Hospital.
InjuryHx.GCSFirstHospNotDone GCS at arrival of first hospital Not done 77 == Not done / Results not available Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This indicates that GCS at for the assessment at First hospital was not done.
InjuryHx.GCSFirstHospPupilLftEyeMeasure Left eye pupil size at First Hospital Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects Left Pupil Size for the assessment at First Hospital.
InjuryHx.GCSFirstHospPupilLftEyeMeasureUnkUnt Left pupil at first hospital Untestable/Unknown 66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This indicates that Left Pupil size was untestable/unknown for the assessment at First Hospital.
InjuryHx.GCSFirstHospPupilReactivityLightLftEyeReslt Left eye pupil reactivity at First Hospital 3 == - (Negative)
1 == + (Sluggish)
2 == + (Brisk)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the reactivity of the Left Pupil for the assessment at First Hospital.
InjuryHx.GCSFirstHospPupilReactivityLightRghtEyeReslt Right eye pupil reactivity at First Hospital 3 == - (Negative)
1 == + (Sluggish)
2 == + (Brisk)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the reactivity of the Right Pupil for the assessment at First Hospital.
InjuryHx.GCSFirstHospPupilRightEyeMeasure Right eye pupil size at First Hospital Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects Right Pupil Size for the assessment at First Hospital.
InjuryHx.GCSFirstHospPupilRightEyeMeasureUnkUnt Right pupil at first hospital Untestable/Unknown 66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects that the Right Pupil size was Untestable/Unknown for the assessment at First Hospital.
InjuryHx.GCSFirstHospPupilSymmetry Pupil symmetry at First Hospital 3 == Unequal L>R
1 == Equal
2 == Unequal R>L
66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the pupil symmetry for the assessment at First Hospital.
InjuryHx.GCSFirstHospReportedTotalScore GCS sum score at first hospital 3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
11 == 11
12 == 12
13 == 13
14 == 14
15 == 15
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects Score by investigators in case component scores not available, but GCS sum score available for the assessment at First Hospital.
InjuryHx.GCSFirstHospScore GCS score at First Hospital Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This is the Calculated Score for the assessment at First Hospital: GCSFirstHospEyes + GCSFirstHospMotor + GCSFirstHospVerbal. If one or more of these is Untestable or unknown then = "No Sum" Sum Score may be recorded with no components
InjuryHx.GCSFirstHospScoreDate Date of GCS assessment at First Hospital Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the Date for the assessment at First Hospital.
InjuryHx.GCSFirstHospScoreTime Time of GCS assessment at First Hospital Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the Time for the assessment at First Hospital.
InjuryHx.GCSFirstHospVerbal Verbal (V) response at First Hospital 1 == 1-None
2 == 2-Incomprehensible sound
3 == 3-Inappropriate words
4 == 4-Confused
5 == 5-Oriented
T == Untestable (tracheotomy/endotracheal tube)
O == Untestable (Other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects the GCS Verbal score for the assessment at First Hospital.
InjuryHx.GCSMotorBaselineDerived IMPACT Motor response This is a derived variable calculated centrally. It represents the GCS motor score for baseline risk adjustment with missing values imputed using IMPACT methodology - take Poststabilisation value and if absent work back in time towards prehospital values until non-missing value found. RECOMMENDED FOR BASELINE RISK ADJUSTMENT.
InjuryHx.GCSOtherAssmtConditions GCS assessment conditions at other stage 0 == No Sedation or Paralysis
2 == Paralyzed
1 == Sedated
3 == Temporary stop of sedation/paralysis
4 == Reversal of sedation/paralysis
5 == Active reversal (pharmacologic) of sedation/paralysis
99 == Other
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes the condition under which the GCS was assessed for the assessment "Other".
InjuryHx.GCSOtherDate Date of GCS assessment at other stage Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes the Date for the assessment "Other".
InjuryHx.GCSOtherEyes Eye opening (E) response at other stage O == Untestable (other)
UN == Unknown
1 == 1-None
2 == 2-To pain
3 == 3-To speech
4 == 4-Spontaneously
S == Untestable (swollen)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes the GCS Eye opening for the assessment "Other".
InjuryHx.GCSOtherMotor Motor (M) response at other stage 1 == 1-None
2 == 2-Abnormal extension
3 == 3-Abnormal flexion
4 == 4-Normal flexion/withdrawal
5 == 5-Localizes to pain
6 == 6-Obeys command
P == Untestable (Deep sedation/paralyzed)
O == Untestable (Other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes GCS Motor score for the assessment "Other".
InjuryHx.GCSOtherNotDone GCS at other than prespecified assessments Not Done 77 == Not done / Results not available Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This indicates that GCS was not done for the assessment "Other".
InjuryHx.GCSOtherPupilLftEyeMeasure Left eye pupil size at other stage Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes Left Pupil Size for the assessment "Other".
InjuryHx.GCSOtherPupilLftEyeMeasureUnkUnt Left pupil at other than prespecified assessments Untestable/Unknown 66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This reflects when the Left Pupil Size was Untestable/Unknown for the assessment "Other".
InjuryHx.GCSOtherPupilReactivityLightLftEyeReslt Left eye pupil reactivity at other stage 3 == - (Negative)
1 == + (Sluggish)
2 == + (Brisk)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes the reactivity of the LEFT pupil for the assessment "Other".
InjuryHx.GCSOtherPupilRightEyeMeasure Right eye pupil size at other stage Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes the Right pupil size for the assessment "Other".
InjuryHx.GCSOtherPupilSymmetry Pupil symmetry at other stage 3 == Unequal L>R
2 == Unequal R>L
1 == Equal
66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes the pupil symmetry for the assessment "Other".
InjuryHx.GCSOtherReactivityLightRghtEyeReslt Right eye pupil reactivity at other stage 3 == - (Negative)
1 == + (Sluggish)
2 == + (Brisk)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes the reactivity of the Right Pupil for the assessment "Other".
InjuryHx.GCSOtherRightEyeMeasureUnkUnt Right pupil at other than prespecified assessments Untestable/Unknown 66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This reflects if the Right pupil was Untestable/Unknown for the assessment "Other".
InjuryHx.GCSOtherScore GCS score at other stage Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This is the Calculated Score for the assessment "Other": GCSOtherEyes + GCSOtherMotor + GCSOtherVerbal. If one or more of these is Untestable or unknown then = "No Sum" Sum score may be reported when components not available
InjuryHx.GCSOtherTime Time of GCS assessment at other stage Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This reflects the Time for the assessment "Other".
InjuryHx.GCSOtherVerbal Verbal (V) response at other stage 1 == 1-None
2 == 2-Incomprehensible sound
3 == 3-Inappropriate words
4 == 4-Confused
5 == 5-Oriented
T == Untestable (tracheotomy/endotracheal tube)
O == Untestable (Other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. There was also an additional option "Other" assessment. This describes the GCS Verbal score for the assessment "Other".
InjuryHx.GcsPreHospBestDate Date of GCS assessment at accident scene Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the Date for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospBestEyes Eye opening (E) response at accident scene 3 == 3-To speech
2 == 2-To pain
1 == 1-None
4 == 4-Spontaneously
S == Untestable (swollen)
O == Untestable (Other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the GCS Eye opening for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospBestMotor Motor (M) response at accident scene 5 == 5-Localizes to pain
4 == 4-Normal flexion/withdrawal
3 == 3-Abnormal flexion
2 == 2-Abnormal extension
1 == 1-None
6 == 6-Obeys command
P == Untestable (Deep sedation/paralyzed)
O == Untestable (Other)
UN == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the GCS Motor score for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospBestReportedTotalScore GCS sum score at scene of accident 3 == 3
4 == 4
5 == 5
6 == 6
7 == 7
8 == 8
9 == 9
10 == 10
11 == 11
12 == 12
13 == 13
14 == 14
15 == 15
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. Score by investigators in case the component scores are not available, but GCS sum score available for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospBestScore GCS score at accident scene Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This is the Calculated Score for the assessment at Scene Of Accident: GCSPreHospBestEyes + GCSPreHospBestMotor + GCSPreHospBestVerbal. If one or more of these is Untestable or unknown then = "No Sum" GCS sum score may be recorded when components not available - check "InjuryHx.GCSPreHospBestReportedTotalScore"
InjuryHx.GcsPreHospBestTime Time of GCS assessment at accident scene Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the Time for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospBestVerbal Verbal (V) response at accident scene 5 == 5-Oriented
2 == 2-Incomprehensible sound
1 == 1-None
4 == 4-Confused
3 == 3-Inappropriate words
T == Untestable (Tracheotomy/endotracheal tube)
UN == Unknown
O == Untestable (Other)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the GCS Verbal score for the assessment at Scene Of Accident.
InjuryHx.GcsPreHospLftEyeMeasr Left eye pupil size at accident scene 6 == 6
5 == 5
4 == 4
3 == 3
2 == 2
1 == 1
7 == 7
8 == 8
9 == 9
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the Left Pupil Size for the assessment at Scene Of Accident.
InjuryHx.GcsPreHospNotDone GCS at scene of accident Not done 77 == Not Done / Results not available Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. Indication that GCS for the assessment at Scene of accident was not done.
InjuryHx.GCSPreHospPupilLftEyeMeasureUnkUnt Left pupil at scene of accident Untestable/Unknown 66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes if the Left Pupil was Untestable/Unknown for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospPupilReactivityLghtLftEyeResult Left eye pupil reactivity at accident scene 1 == + (Sluggish)
3 == - (Negative)
2 == + (Brisk)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the reactivity of the Left pupil for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospPupilReactivityLghtRghtEyeResult Right eye pupil reactivity at accident scene 1 == + (Sluggish)
3 == - (Negative)
2 == + (Brisk)
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the reactivity of the Right pupil for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospPupilRightEyeMeasureUnkUnt Right pupil at scene of accident Untestable/Unknown 66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This reflects if the Right Pupil was Untestable/Unknown for the assessment at Scene Of Accident.
InjuryHx.GCSPreHospPupilSymmetry Pupil symmetry at accident scene 1 == Equal
3 == Unequal L>R
2 == Unequal R>L
66 == Untestable
88 == Unknown
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the Pupil symmetry for the assessment at Scene Of Accident.
InjuryHx.GcsPreHospRghtEyeMeasr Right eye pupil size at accident scene 9 == 9
6 == 6
5 == 5
4 == 4
3 == 3
2 == 2
1 == 1
7 == 7
8 == 8
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the Right Pupil Size for the assessment at Scene Of Accident.
InjuryHx.GCSScoreBaselineDerived IMPACT GCS score This is a derived variable calculated centrally. It represents the total GCS (single timepoint) for baseline risk adjustment with missing values imputed using IMPACT methodology - take Poststabilisation value and if absent work back in time towards prehospital values until non-missing value found. Intubated / untestable V score treated as unknown. RECOMMENDED FOR BASELINE RISK ADJUSTMENT.
InjuryHx.HeadNeckAIS Head and Neck AIS 0 == 0
5 == 5
6 == 6
4 == 4
2 == 2
3 == 3
1 == 1
AIS score for the Head and Neck region. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.HeadNeckDesc Head and Neck injury description Injury description for the Head and Neck AIS.
InjuryHx.HighestGCSMotorDerived Highest Motor response This is a derived variable calculated centrally. It represents the GCS motor score for baseline risk adjustment with missing values imputed using ‘highest’ value (best neurology) methodology- take best neurology of any of prehospital to Poststabilisation time points. DEPRECATED: we recommend using GCSMotorBaselineDerived for baseline risk adjustment instead (higher pseudo-R-squared in proportional odds model).
InjuryHx.HighestGCSTotalDerived Highest GCS score This is a derived variable calculated centrally. Total GCS (single timepoint) for baseline risk adjustment with missing values imputed using ‘highest’ value (best neurology) methodology - take best neurology of any of prehospital to Poststabilisation time points. Intubated / untestable V score treated as unknown. DEPRECATED: we recommend using GCSScoreBaselineDerived for baseline risk adjustment instead (higher pseudo-R-squared in proportional odds model).
InjuryHx.HighestPupilsDerived Highest unreactive pupils This is a derived variable calculated centrally. Number of unreactive pupils for baseline risk adjustment with missing values imputed using ‘highest’ value (best neurology) methodology- take best neurology of any of prehospital to Poststabilisation time points. Untestable pupil ignored: I.e. 1 reactive + 1 untestable = 1 reactive (this assumption applies only to a small proportion of the data). DEPRECATED: we recommend using PupilsBaselineDerived for baseline risk adjustment instead (higher pseudo-R-squared in proportional odds model).
InjuryHx.InjArea Area of injury 88 == Unknown
2 == Rural
1 == Urban (city)
Reflects the area where the injury took place (urban or rural).
InjuryHx.InjCause Cause of injury 1 == Road traffic incident
2 == Incidental fall
3 == Other non-intentional injury
4 == Violence/assault
5 == Act of mass violence
6 == Suicide attempt
99 == Other
88 == Unknown
Reflects the cause of injury.
InjuryHx.InjCauseOther Other cause of injury (please specify) Reflects if the cause of injury was "other" than the pre-listed causes. See also InjuryHx.InjCause
InjuryHx.InjIndContactSportType Sports injury: Individual contact sports 1 == Boxing
2 == Martial Arts
99 == Other
Reflects the kind of contact sport involved as cause of injury - Only applicable for sports/recreational injuries
InjuryHx.InjIndSportTypeOther Sports injury: Other individual contact sports (please specify) Reflects if the kind of contact sport involved as cause of injury was "other" than the pre-defined list - Only applicable for sports/recreational injuries. See also InjuryHx.InjIndContactSportType
InjuryHx.InjIntention Intention 3 == Undetermined
1 == Intentional
2 == Unintentional
Reflects if the cause on injury was intentional or unintentional.
InjuryHx.InjMech Mechanism of injury 1 == High velocity trauma (acceleration/deceleration)
2 == Direct impact: blow to head
3 == Direct impact: head against object
6 == Ground level fall
7 == Fall from height > 1 meter/5 stairs
99 == Other closed head injury
Reflects the mechanism of injury - only applicable for Closed TBI
InjuryHx.InjMechOther Mechanism of injury: Other closed head injury (please specify) Reflects if the mechanism of injury was "other" than the pre-defined list - only applicable for Closed TBI. See also InjuryHx.InjMech
InjuryHx.InjOtherPartyInvolved Was other party involved? 77 == N/A Reflects that "another party involved in the cause of injury = N/A".
InjuryHx.InjOtherPartySleepingPills Was other party under the influence of sedatives or sleeping pills? 0 == No
1 == Suspect
2 == Definite
88 == Unknown
Reflects if sedatives or sleeping pills were involved in the cause of injury.
InjuryHx.InjPenetratingType Mechanism of penetrating injury 1 == Gunshot wound
2 == Fragment (incl. shell/shrapnel)
99 == Other penetrating brain injury
Reflects the mechanism of injury - only applicable if Penetrating brain injury
InjuryHx.InjPenetratingTypeOther Other mechanism of penetrating injury (please specify) Reflects if the mechanism of injury was other than the pre-defined list - only applicable if Penetrating brain injury. See also InjuryHx.InjPenetratingType
InjuryHx.InjPlace Place of injury 99 == Other
3 == Work/school
88 == Unknown
5 == Military deployment
4 == Sport/Recreational
1 == Street/highway
2 == Home/domestic
6 == Public location (eg. bar, station, nightclub)
Reflects the place where the TBI injury occurred.
InjuryHx.InjPlaceOther Other place of injury (please specify) Reflects if the place where the TBI injury occurred was "other" than the pre-defined list. See also InjuryHx.InjPlace
InjuryHx.InjRecSportType Sports injury: Other sports and recreational activities 1 == Rollerblading/Skateboarding/Scootering
2 == Skiing
3 == Snowboarding
4 == Hiking/Climbing
5 == Horseriding
6 == Golf
7 == Cycling
8 == Off-road vehicular sports
9 == Water sports
10 == Playground activity
99 == Other
88 == Unknown
Reflects of the cause of injury was "Other Sport & Recreational Activities" - Only applicable for sports/recreational injuries
InjuryHx.InjRecSportTypeOther Sports injury: Any other sports and recreational activities (please specify) Describes which was the cause of injury if "Other Sport & Recreational Activities" - Only applicable for sports/recreational injuries
InjuryHx.InjRoadAccEjectedFromVehicle Road traffic accident injury: Ejected from vehicle 0 == No
1 == Yes
88 == Unknown
Reflects if the subject was ejected from the vehicle - Only applicable if subject was motor vehicle occupant
InjuryHx.InjRoadAccOtherParty Road traffic accident injury: Victim 1 == Motor vehicle
2 == Pedestrian
3 == Cyclist
4 == Moped/Scooter
5 == Tram/Bus
6 == Train/Metro
7 == Obstacle
10 == Motor Bike
88 == Unknown
99 == Other
11 == Lorry (camion)
Reflects if another party was involved in the Cause of Injury in case of a Road Traffic accident
InjuryHx.InjRoadAccOtherPartyInvolved Road traffic accident injury: Other party involved 0 == No
1 == Yes
88 == Unknown
Describes if another party than the pre-defined list was involved in the Cause of Injury in case of a Road Traffic accident
InjuryHx.InjRoadAccOtherPartyOther Road traffic accident injury: Other victim (please specify) Describes which other party than the pre-defined list was involved in the Cause of Injury in case of a Road Traffic accident
InjuryHx.InjRoadAccVictim Road traffic accident injury: Victim 1 == Motor vehicle occupant
2 == Pedestrian
3 == Cyclist
4 == Moped/Scooter
5 == Motor Bike
99 == Other
Describes the type of victim in case of a Road traffic accident.
InjuryHx.InjRoadAccVictimOther Road traffic accident injury: Other victim (please specify) Reflects if the type of victim was "other" than the predefined list in case of a Road traffic accident.
InjuryHx.InjRoadAccVictimVehiclePlace Road traffic accident injury: Occupant's placement in vehicle 1 == Driver
2 == Front seat passenger
3 == Back seat passenger
Reflects the occupant placement of the victim in the vehicle in case of a Road Traffic Accident
InjuryHx.InjSafetyAirbag Airbag deployed 88 == Unknown
77 == Not Applicable
0 == No
1 == Yes
Perfects if the airbag was deployed - Only applicable if subject was motor vehicle occupant
InjuryHx.InjSafetyHelmet Helmet used 88 == Unknown
77 == Not Applicable
0 == No
1 == Yes
Reflects if the victim was wearing a safety helmet. Only applicable in case of cyclist, scooter, motorbike incident. However, may also have been scored for various sports injuries.
InjuryHx.InjSafetySeatbelt Seatbelt used 88 == Unknown
77 == Not Applicable
0 == No
1 == Yes
Reflects if the victim was wearing a seat-belt. Only applicable if subject was motor vehicle occupant
InjuryHx.InjTeamSportType Sports injury: Team sports 1 == Football (soccer)
2 == Rugby
3 == Field Hockey
4 == Ice Hockey
5 == Lacrosse
99 == Other
Reflects the type of team sport that was the cause of the injury - Only applicable for sports/recreational injuries
InjuryHx.InjTeamSportTypeOther Sports injury: Other team sports (please specify) Reflects if the type of team sport that was the cause of the injury was "other" than the predefined list- Only applicable for sports/recreational injuries
InjuryHx.InjType Type of injury 1 == Closed
88 == Unknown
3 == Crush
2 == Blast
5 == Penetrating
6 == Penetrating-perforating
7 == Penetrating-tangential
8 == Closed with open depressed skull fracture
Details of Injury are captured in 4 different variables: Type of Injury, Place of Injury, Cause of Injury and Mechanism of injury. This reflects the type of injury.
InjuryHx.InjVictimAlcoholTestType Test used to determine whether the victim was under the influence of alcohol Blood == Blood Test
Breath == Breath Test
Reflects type of alcohol test used (breath test or blood test) for the victim
InjuryHx.InjVictimBloodAlcoholmgdL Alcohol level in victim's blood Reflects the level of mg/dL alcohol recorded in the victim during the alcohol test in case alcohol was related to the cause of injury.
InjuryHx.InjVictimBloodAlcoholpermil Alcohol level in victim's blood Reflects the level of alcohol per mil (0/00) recorded in the victim during the alcohol test in case alcohol was related to the cause of injury.
InjuryHx.InjVictimBloodAlcoholUnit Unit used for alcohol level of victim (if applicable) 1 == mg/dL
2 == per mil (0/00)
Reflects the value used for alcohol level recorded during the alcohol test of the victim in case alcohol was related to the cause of injury.
InjuryHx.InjVictimDrugsTypeOther If the victim was under the influence of other drugs (please specify) Describes which other drugs where involved for the victim in the cause of injury.
InjuryHx.InjVictimSleepingPills Was victim under the influence of sedatives or sleeping pills? 0 == No
1 == Suspect
2 == Definite
88 == Unknown
Reflects if for the victim use of sedatives of sleeping pills were involved in the cause of injury.
InjuryHx.InjVictimTypeDrugs Was victim under the influence of drugs? 88 == Unknown
1 == Cannabis
2 == Cocaine
3 == Methamphetamine's
4 == Opioids
5 == XTC
99 == Other
Rf elects which kind of drugs were involved in the cause of injury at the victims site.
InjuryHx.InjViolence Type of violence injury 1 == Robbery
2 == Interpersonal violence (fight)
3 == Domestic assault
4 == Child abuse
5 == Gang violence
6 == Military deployment
99 == Other
88 == Unknown
Reflects the type of violence used as cause of injury - Only applicable if violence was the cause of injury
InjuryHx.InjViolenceOther Other type of violence injury (please specify) Reflects the "other" type of violence than the predefined list used as cause of injury - Only applicable if violence was the cause of injury
InjuryHx.InjViolenceOtherPartyAlcohol Substance abuse: Other party under the influence of Alcohol 1 == Definite
2 == Suspect
0 == No
88 == Unknown
Information on drug and alcohol abuse of possible influence on the incident is different for victim versus "other party" (if involved) This reflects if alcohol was involved in the cause of injury for the other party involved
InjuryHx.InjViolenceOtherPartyDrugs Substance abuse: Other party under the influence of Drugs 0 == No
2 == Suspect
1 == Definite
88 == Unknown
Information on drug and alcohol abuse of possible influence on the incident is different for victim versus "other party" (if involved). This reflects if drugs was involved as cause of injury for the other party involved
InjuryHx.InjViolenceVictimAlcohol Substance abuse: Victim under the influence of Alcohol 0 == No
2 == Suspect
1 == Definite
88 == Unknown
Information on drug and alcohol abuse of possible influence on the incident is different for victim versus "other party" (if involved) This reflects alcohol involvement for the victim.
InjuryHx.InjViolenceVictimDrugs Substance abuse: Victim under the influence of Drugs 0 == No
2 == Suspect
1 == Definite
88 == Unknown
Information on drug and alcohol abuse of possible influence on the incident is different for victim versus "other party" (if involved) This reflects drugs involvement for the victim.
InjuryHx.InterventRadiology Interventional radiology scheduled at ER discharge 0 == No
1 == Yes
88 == Unknown
Reflects if at time of discharge from the ER some Interventional Radiology was scheduled
InjuryHx.LOCAOC AOC (Alteration of Consciousness) 88 == Unknown
3 == Suspected
1 == Yes, immediate
0 == No
2 == Not tested due to LOC
4 == Yes, delayed onset
TBI may be present in the absence of LOC or PTA. Alteration of Consciousness (AOC) is then the main presenting symptom and considered diagnostic of TBI. Details of symptoms are captured in the Rivermead Questionnaire.
InjuryHx.LOCAOCDelayedHrs AOC: Number of hours after injury that alteration of consciousness occurred TBI may be present in the absence of LOC or PTA. Alteration of Consciousness (AOC) is then the main presenting symptom and considered diagnostic of TBI. This reflects the Number of hours after injury that alteration of consciousness occurred - Only in case of delayed onset. Details of symptoms are captured in the Rivermead Questionnaire.
InjuryHx.LOCAOCDelayedHrsUnk Number of hours after injury that AOC occured Unknown TBI may be present in the absence of LOC or PTA. Alteration of Consciousness (AOC) is then the main presenting symptom and considered diagnostic of TBI. This reflects if the Number of hours after injury that alteration of consciousness occurred = Unknown. Details of symptoms are captured in the Rivermead Questionnaire.
InjuryHx.LOCAOCDuration AOC: Duration of LOC 88 == Unknown
7 == >7 days
6 == 1-7 days
5 == 1-24 hours
4 == 30-59 minutes
3 == 1-29 minutes
2 == <1 minute
0 == None
TBI may be present in the absence of LOC or PTA. Alteration of Consciousness (AOC) is then the main presenting symptom and considered diagnostic of TBI. This reflects the Duration of alteration of consciousness. Details of symptoms are captured in the Rivermead Questionnaire.
InjuryHx.LOCAOCReportedBy AOC: Source of verification 4 == Medical chart
3 == Clinical interview
2 == Witness
1 == Patient
5 == Not available
TBI may be present in the absence of LOC or PTA. Alteration of Consciousness (AOC) is then the main presenting symptom and considered diagnostic of TBI. This reflects by whom the alteration of consciousness was reported. Details of symptoms are captured in the Rivermead Questionnaire.
InjuryHx.LOCDuration LOC: Duration of LOC 6 == 1-7 days
5 == 1-24 hours
3 == 1-29 minutes
4 == 30-59 minutes
2 == <1 minute
0 == No return of consciousness
7 == >7 days
88 == Unknown
LOC and PTA are reported as part of the neurological assessment. This reflects the duration of Loss of Consciousness (LOC). Note: for patients admitted to hospital, the time to obeying commands is documented on hospital discharge: Hospital.HospDischargeTimeToObeyCommands
InjuryHx.LOCGCSSumDet GCS sum score deterioration within one hour after presentation 88 == Unknown
2 == 2 or more points
1 == 1 point
0 == None
LOC and PTA are reported as part of the neurological assessment. This reflects for the Loss of Consciousness (LOC) the GCS sum score deterioration within one hour after presentation.
InjuryHx.LOCLossOfConsciousness LOC (Loss Of Consciousness) 88 == Unknown
1 == Yes
3 == Suspected
0 == No
LOC and PTA are reported as part of the neurological assessment. Loss of Consciousness (LOC) is a definite sign of TBI. However, TBI may be present without any LOC. Presence and duration is captured.
InjuryHx.LOCLucidInterval LOC: Lucid Interval 1 == Yes
0 == No
88 == Unknown
LOC and PTA are reported as part of the neurological assessment. Lucid Interval is defined as a temporary improvement in a patient's condition after a traumatic brain injury, after which the condition deteriorates. A lucid interval is especially indicative of an epidural hematoma. An estimated 20 to 50% of patients with epidural hematoma experience such a lucid interval.
InjuryHx.LOCLucidIntervalHrs LOC: Number of hours after injury that secondary deterioration occurred Lucid Interval is defined as a temporary improvement in a patient's condition after a traumatic brain injury, after which the condition deteriorates. This reflects the Number of hours after injury that secondary deterioration occurred (in case Lucid Interval = Yes)
InjuryHx.LOCLucidIntervalHrsUnk Number of hours after injury that secondary deterioration occured Unknown Lucid Interval is defined as a temporary improvement in a patient's condition after a traumatic brain injury, after which the condition deteriorates. This reflects if the Number of hours after injury that secondary deterioration occurred is Unknown (in case Lucid Interval = Yes).
InjuryHx.LOCPTA PTA (Post Traumatic Amnesia) 3 == Suspected
1 == Yes, ongoing
88 == Unknown
0 == No
2 == Yes, resolved
LOC and PTA are reported as part of the neurological assessment. Post-traumatic amnesia (PTA) is the period after the injury that the patient cannot remember. In contrast to retrograde amnesia, the duration of PTA remains constant over time. To document presence/absence of PTA on discharge from the ER, the GOAT questionnaire is requested: Outcomes.GOATDate
InjuryHx.LOCPTADuration PTA: Duration of LOC 28 == >28
6 == 1-7 days
5 == 1-24 hours
2 == <1 hour
88 == Unknown
77 == N/A (e.g. death)
0 == None
8 == 1-2 hours
9 == 2-4 hours
10 == 4-24 hours
11 == >1 day
7 == 7-28 days
LOC and PTA are reported as part of the neurological assessment. This variable is recorded only Only if PTA is yes. The duration of PTA reflects the severity of TBI. In patients with more sever TBI, the duration of PTA cannot be determined on presentation. For patients admitted to hospital, the duration of TBI in days is also captured on hospital discharge:.Hospital.HospDischPTADays
InjuryHx.LOCPTAReportedBy PTA: Source of verification 1 == Patient
2 == Witness
3 == Retrospective assessment/ clinical interview
4 == Medical chart
5 == Not available
6 == Prospective assessment with PTA scale
LOC and PTA are reported as part of the neurological assessment. This reflects by whom PTA is reported.
InjuryHx.LOCPTAScale PTA: Scale used 1 == GOAT
2 == Westmead
3 == O-Log
4 == Nijmegen PTA scale
99 == Other
LOC and PTA are reported as part of the neurological assessment. In some centres, prospective assessment of amnesia (PTA) after TBI is performed using a dedicated scale. This variable documents the scale used.
InjuryHx.LOCReportedBy LOC: Source of verification 2 == Witness
1 == Self report
3 == Clinical interview
4 == Medical chart
5 == Not available
LOC and PTA are reported as part of the neurological assessment. This variable reflects by whom LOC was reported.
InjuryHx.LOCRGA Retrograde Amnesia 1 == Yes
88 == Unknown
0 == No
This reflects presence or absence of retrograde amnesia during neurological assessment. Amnesia after injury is a sign of TBI. Retrograde amnesia is the period before the injury that the patient cannot remember. The duration of retrograde amnesia becomes shorter as the injury is longer ago. The duration of retrograde amnesia is therefore dependent on time after injury at which it was assessed.
InjuryHx.LOCRGADur Retrograde Amnesia: Duration 88 == Unknown
2 == >= 30 minutes
1 == <30
0 == None
This reflects the duration of retrograde amnesia is present during neurological assessment.
InjuryHx.LOCRGAReportBy Retrograde Amnesia: Source of verification 4 == Medical chart
5 == Not available
3 == Clinical interview
2 == Witness
1 == Self report
This reflects by whom Retrograde amnesia was reported if present during neurological assessment.
InjuryHx.LowerExtremitiesAIS Lower Extremities AIS AIS score for Lower extremities as subdomain of Extremities and pelvic girdle. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.LowerExtremitiesDesc Lower Extremities injury description 2 == Tibia plateau fracture
3 == Tibia fracture
4 == Ankle fracture
5 == Calcaneus fracture
6 == Metatarsal/tarsal fracture (toe fracture)
7 == Fibula fracture
1 == Femoral fracture
Injury Description for the AIS score for Lower extremities as subdomain of Extremities and pelvic girdle.
InjuryHx.LumbarSpineAIS Lumbar Spine AIS AIS score for Lumbar spine as subdomain of Abdomen/Pelvic contents. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.LumbarSpineDesc Lumbar Spine injury description 1 == Fracture
2 == Dislocation
3 == Sacral fracture
99 == Other
Injury description for AIS score for Lumbar spine as subdomain of Abdomen/Pelvic contents.
InjuryHx.NeuroAssmtsAVPU AVPU score at ER arrival 88 == Unknown
P == The patient responds to painful stimulation
V == Patient responds to verbal stimulation
A == Patient is awake
U == The patient is completely unresponsive
AVPU is scored as part of the neurological assessment on arrival to the ER. The AVPU scale (an acronym from "alert, voice, pain, unresponsive") is a system by which a health care professional can measure and record a patient's responsiveness, indicating their level of consciousness.
InjuryHx.PainScale Pain rating (0 = No pain; 100 = Unbearable pain) During neurological assessment at arrival to ER an overall rating was recorded for pain intensity going from 0 (zero pain) to 100 (unbearable pain).
InjuryHx.PainScaleUnk Pain intensity at ER arrival Untestable/Unknown 88 == Unknown
77 == Untestable
During neurological assessment at arrival to ER an overall rating was recorded for pain intensity going from 0 (zero pain) to 100 (unbearable pain). This variable reflects if the pain intensity was Untestable of Unknown.
InjuryHx.PelvicGirdleAIS Pelvic Girdle AIS AIS score for Pelvic Girdle as subdomain of Extremities and pelvic girdle. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.PelvicGirdleDesc Pelvic Girdle injury description 3 == Hip dislocation
2 == Hip fracture
1 == Pelvic fracture
Injury description for AIS score for Pelvic Girdle as subdomain of Extremities and pelvic girdle.
InjuryHx.PreHospAssmtConditions GCS assessment conditions at accident scene 0 == No sedation or paralysis
1 == Sedated
3 == Temporary stop of sedation/paralysis
4 == Reversal of sedation/paralysis
5 == Active reversal (pharmacologic) of sedation/paralysis
99 == Other
2 == Paralyzed
Neurological assessment (GCS and pupils) was recorded for the scene of accident, the first hospital (if applicable), the Arrival to ER of the study hospital and post-stabilization. This describes the condition under which the GCS was assessed for the assessment at Scene Of Accident.
InjuryHx.PresArrivalMethod Mode of transport from accident scene 99 == Other
4 == Walk in or drop off
1 == Ambulance
2 == Helicopter
3 == Medical mobile team
Reflects the mode of transportation used to transport the subject from the scene of accident to the hospital.
InjuryHx.PresCirculationTreatmentCPR Circulation: CPR The status of Airway, Breathing and Circulation on scene are documented. This records Emergency care treatment on scene performed with regard to Circulation: CPR (Cardio-pulmonary resuscitation) ER arrival status is documented at: InjuryHX.EDArrivalCirculation
InjuryHx.PresCirculationTreatmentIVFluids Circulation: IV Fluids The status of Airway, Breathing and Circulation on scene are documented. This records Emergency care treatment on scene performed with regard to Circulation: IV Fluids ER arrival status is documented at: InjuryHX.EDArrivalCirculation
InjuryHx.PresCirculationTreatmentNone Circulation: No treatment The status of Airway, Breathing and Circulation on scene are documented. This records Emergency care treatment on scene performed with regard to Circulation: None ER arrival status is documented at: InjuryHX.EDArrivalCirculation
InjuryHx.PresCirculationTreatmentUnknown Circulation treatment at on scenen Emergency care treatment Unknown The status of Airway, Breathing and Circulation on scene are documented. This records Emergency care treatment on scene performed with regard to Circulation: Unknown ER arrival status is documented at: InjuryHX.EDArrivalCirculation
InjuryHx.PresCTBrain CT scan at First Hospital 88 == Unknown
0 == No
1 == Yes
In case of a Secondary referral (see InjuryHx.PresTBIref), details of procedures performed at the first hospital (not study hospital) were recorded. This reflects if a CT Brain was performed in the first hospital (not study hospital).
InjuryHx.PresEmergencyCare Emergency medical care at accident scene 0 == None
1 == Untrained person (by stander)
2 == Trainer/coach
3 == Military, non-medic
4 == Paramedic
5 == Nurse
6 == Physician
7 == Medical rescue team
99 == Other
Reflects if and by whom emergency medical care was given at the scene of accident (highest level of assistance)
InjuryHx.PresEmergencyCareIntubation Emergency care on scene: Intubation 0 == No
1 == Yes
88 == Unknown
Reflects if intubation was performed on scene.
InjuryHx.PresEmergencyCareSuppOxygen Emergency care on scene: Supplemental oxygen 0 == No
1 == Yes
88 == Unknown
Reflects if supplemental oxygen was given on scene.
InjuryHx.PresEmergencyCareVentilation Emergency care on scene: Mechanical ventilation 0 == No
1 == Yes
88 == Unknown
Reflects if Mechanical Ventilation was done on scene.
InjuryHx.PresEmergencyServiceAmbuBasic Emergency service involved at accident scene: Ambulance (basic: EMT-B) Reflects type of Emergency service involved at accident scene --> Ambulance (basic EMT­B)
InjuryHx.PresEmergencyServiceAmbuSpec Emergency service involved at accident scene: Ambulance specialized (EMT-P) Reflects type of Emergency service involved at accident scene --> Ambulance specialized (EMT­P)
InjuryHx.PresEmergencyServiceFirefighter Emergency service involved at accident scene: Firefighter Reflects type of Emergency service involved at accident scene --> Firefighter
InjuryHx.PresEmergencyServiceHelicopter Emergency service involved at accident scene: Helicopter Reflects type of Emergency service involved at accident scene --> Helicopter
InjuryHx.PresEmergencyServiceNone Emergency service involved at accident scene: None Reflects type of mergency service involved at accident scene --> None
InjuryHx.PresEmergencyServicePolice Emergency service involved at accident scene: Police Reflects type of Emergency service involved at accident scene --> Police
InjuryHx.PresERExtracranialSurg Emergency Extracranial surgery at First Hospital 1 == Yes
0 == No
88 == Unknown
In case of a Secondary referral (see InjuryHx.PresTBIref), details of procedures performed at the first hospital (not study hospital) were recorded. This reflects if Emergency intracranial surgery was performed in the first hospital (not study hospital).
InjuryHx.PresERIntracranialSurg Emergency Intracranial surgery at First Hospital 88 == Unknown
0 == No
1 == Yes
In case of a Secondary referral (see InjuryHx.PresTBIref), details of procedures performed at the first hospital (not study hospital) were recorded. This reflects if Emergency extracranial surgery was performed in the first hospital (not study hospital). Surgical procedures decided on to perform directly on arrival to the Study hospital are recorded within InjuryHx.EmergSurgInterventionsIntraCran.
InjuryHx.PresFHospDate Date of arrival at the First Hospital In case of a Secondary referral (see InjuryHx.PresTBIref), details of procedures performed at the first hospital (not study hospital) were recorded. First hospital is defined as the initial hospital to which the patient was brought before being transferred to Study hospital. This reflects Date of arrival to first hospital.
InjuryHx.PresFHospTime Time of arrival at the First Hospital In case of a Secondary referral (see InjuryHx.PresTBIref), details of procedures performed at the first hospital (not study hospital) were recorded. First hospital is defined as the initial hospital to which the patient was brought before being transferred to Study hospital. This reflects Time of arrival to first hospital.
InjuryHx.PresFirstOnSceneDate Time of arrival of emergency service at accident scene Reflects Times at accident scene --> First on scene --> Date
InjuryHx.PresFirstOnSceneDepartUnknownTime Departure time of EMS at accident scene N/A or Unknown 88 == Unknown
77 == N/A if emergency service=none
Reflects Times at accident scene --> Departure time -->N/A (if emergency service=none) or when Unknown
InjuryHx.PresFirstOnSceneDepartureDate Date of departure of emergency service from accident scene Reflects Times at accident scene --> Departure time --> Date
InjuryHx.PresFirstOnSceneDepartureTime Time of departure of emergency service from accident scene Reflects Times at accident scene --> Departure time --> Time
InjuryHx.PresFirstOnSceneTime Time of arrival of emergency service at accident scene Reflects Times at accident scene --> First on scene --> Time
InjuryHx.PresFirstOnSceneUnknownTime Arrival time of EMS at accident scene N/A or Unknown 88 == Unknown
77 == N/A if emergency service=none
Reflects if Time of arrival of EMS to incident scene = unknown or N/A (f.e. if no EMS involved)
InjuryHx.PresIntubation Intubated at First Hospital 88 == Unknown
0 == No
1 == Yes
In case of a Secondary referral (see InjuryHx.PresTBIref), details of procedures performed at the first hospital (not study hospital) were recorded. This reflects if the subject was intubated at first hospital (not study hospital).
InjuryHx.PresSTHospDate Date of arrival at the Study Hospital Reflects the Date of arrival to study hospital
InjuryHx.PresSTHospTime Time of arrival at the Study Hospital Reflects Time of arrival to study hospital
InjuryHx.PresTBIRef Referral 2 == Secondary
1 == Primary
Reflects if the subject was transported from the scene of accident immediately to the study hospital (primary referral) or if secondary referral occurred from a first hospital to the Study hospital.
InjuryHx.PupilsBaselineDerived IMPACT unreactive pupils This is a derived variable calculated centrally. Number of unreactive pupils for baseline risk adjustment with missing values imputed using IMPACT methodology- take Poststabilisation value and if absent work back in time towards prehospital values until non-missing value found. Untestable pupil ignored: I.e. 1 reactive + 1 untestable = 1 reactive (this assumption applies only to a small proportion of the data). RECOMMENDED FOR BASELINE RISK ADJUSTMENT.
InjuryHx.PupilsNonSymmetric Non-symmetric pupils Pupil symmetry derived variable calculated from (GCSFirstHospPupilSymmetry,EDArrPupilSymmetry,GCSPreHospPupilSymmetry,EDDischPupilSymmetry,PupilsNonSymmetric)
InjuryHx.SedativeCurrentUse Use in the past three months: Sedatives or sleeping pills 0 == No
1 == Yes
88 == Unknown
On presentation the behavioral history of the patient was recorded. This reflects if in the past three months the subjects used sedatives or sleeping pills.
InjuryHx.SedativePriorUse Past use: Sedatives or sleeping pills 0 == No
1 == Yes
88 == Unknown
On presentation the behavioral history of the patient was recorded. This reflects his past use of Sedatives or sleeping pill.
InjuryHx.SedativePriorUseDuration Past use: No. of years of use of sedatives or sleeping pills On presentation the behavioral history of the patient was recorded. This reflects the number sof years of his past use sedatives (if applicable).
InjuryHx.SympSkullFract Clinical signs of skull base fracture (e.g. raccoon eyes, battle sign, hemotympanun, CSF otorrhea, CRF rhinorrhea, bleeding from ear) 88 == Unknown
0 == No
1 == Yes
During neurological assessment at arrival in the ER, Clinical signs of skull base fracture (e.g. raccoon eyes, battle sign, hemotympanun, CSF otorrhea, CRF rhinorrhea, bleeding from ear) were recorded.
InjuryHx.SympVomiting Vomiting 0 == No
1 == Once
2 == More than once
88 == Unknown
During neurological assessment at arrival in the ER, Vomiting was recorded.
InjuryHx.ThoracicSpineAIS Thoracic Spine AIS AIS score for the Thoracic Spine as subdomain of Thorax/Chest. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.ThoracicSpineDesc Thorax Spine injury description 1 == Fracture
2 == Dislocation
Injury description for the AIS of Thoracic spine as subdomain of Thorax/Chest
InjuryHx.ThoraxChestAIS Thorax/Chest AIS AIS score for the Thorax/Chest region. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.ThoraxChestDesc Thorax/Chest injury description 99 == Other
6 == Hemato-thorax
4 == Aorta dissection
5 == Pneumo-thorax
3 == Cardiac contusion
1 == Rib fracture
2 == Lung contusion
Injury description for the AIS of the Thorax/Chest region.
InjuryHx.TobcoCurntUseInd Use in the past three months: Tobacco products (cigarettes, cigars, pipe, chewing tobacco, etc.) 0 == No
1 == Yes
88 == Unknown
On presentation the behavioral history of the patient was recorded. This reflects his use in the past three months of Tobacco products (cigarettes, cigars, pipe, chewing tobacco, etc.)
InjuryHx.TobcoPriorUseInd Past use: Tobacco products (cigarettes, cigars, pipe, chewing tobacco, etc.) 0 == No
1 == Yes
88 == Unknown
The form "Behavioral History" captures information on past and current use of alcohol, tobacco, sedatives/sleeping pills, cannabis and other recreational drugs. Use is differentiated as "Past user" (eg stopped) versus "use in the past 3 months. Note: These variables do not reflect use of these substances at the time of injury.
InjuryHx.TobcoUseDur Past use: No. of years of use of tobacco (cigarettes, cigars, pipe, chewing tobacco, etc.) On presentation the behavioral history of the patient was recorded. This reflects the number of years of his past use of Tobacco (if applicable).
InjuryHx.TotalISS Total ISS The Injury Severity Score is calculated as the sum of the squares of the the 3 body regions with the highest AIS score. The max score for the ISS = 75. If any body region AIS is assigned a score of "6", the ISS is automatically set to 75 (highest score). In the calculation of the ISS, only the 6 main body regions are taken into consideration.
InjuryHx.UpperExtremitiesAIS Upper Extremities AIS AIS score of the Upper extremities as subdomain of Extremities and pelvic girdle. In the original AIS classification of injury severity, the grading is from 1 (minor) to 6 (unsurvivable). We added a score of 0 to designate absence of injuries.
InjuryHx.UpperExtremitiesDesc Upper Extremities injury description 5 == Finger
3 == Dislocation
4 == Hand
2 == Radial and/or ulnar fracture
1 == Humerus fracture
Injury description for the AIS score of the Upper extremities as subdomain of Extremities and pelvic girdle.
Labs.DLA10Extem A10 (Amplitude/clot firmness at 10 minutes) measured from EXTEM test Only applicable to sites doing ROTEM studies. ROTEM --> A10 --> EXTEM
Labs.DLA10Fibtem A10 (Amplitude/clot firmness at 10 minutes) measured from FIBTEM test Only applicable to sites doing ROTEM studies. ROTEM --> A10 --> FIBTEM
Labs.DLA10NotDone ROTEM A10 labs Not Done Only applicable to sites doing ROTEM studies. ROTEM --> A10 --> Not Done
Labs.DLA5Extem A5 (Amplitude/clot firmness at 5 minutes) measured from EXTEM test Only applicable to sites doing ROTEM studies. ROTEM --> A5 --> EXTEM
Labs.DLA5Fibtem A5 (Amplitude/clot firmness at 5 minutes) measured from FIBTEM test Only applicable to sites doing ROTEM studies ROTEM --> A5 --> FIBTEM
Labs.DLA5NotDone ROTEM A5 labs Not Done Only applicable to sites doing ROTEM studies. ROTEM --> A5 --> Not Done
Labs.DLaAngleExtem alpha-angle measured from EXTEM test Only applicable to sites doing ROTEM studies. ROTEM --> α-angle --> EXTEM
Labs.DLaAngleFibtem alpha-angle measured from FIBTEM test Only applicable to sites doing ROTEM studies. ROTEM --> α-angle --> FIBTEM
Labs.DLaAngleNotDone ROTEM α-angle labs Not Done Only applicable to sites doing ROTEM studies. ROTEM --> α-angle --> Not Done
Labs.DLACT ACT (Activated Clotting Time) Only applicable to sites doing ROTEM/TEG studies. TEG --> ACT (rapid TEG only)
Labs.DLACTNotDone TEG ACT labs Not Done Only applicable to sites doing ROTEM/TEG studies. TEG --> ACT --> Not Done
Labs.DLADPAggreg Aggregation measured from ADP (Adenosine diphosphate) test Only applicable to sites doing multiplate studies. MULTIPLATE TEST --> ADP Test --> Aggregation
Labs.DLADPAUC AUC measured from ADP (Adenosine diphosphate) test Only applicable to sites doing multiplate studies. MULTIPLATE TEST --> ADP Test --> AUC (AU*min)
Labs.DLADPAUCU Multiplate ADP test AUC in U Only applicable to sites doing multiplate studies MULTIPLATE TEST --> ADP Test --> AUC (U)
Labs.DLADPVelocity Velocity measured from ADP (Adenosine diphosphate) test Only applicable to sites doing multiplate studies. MULTIPLATE TEST --> ADP Test --> Velocity
Labs.DLAlatSgptNotDone Blood chemistry ALAT/SGPT Not Done BLOOD CHEMISTRY --> ALAT/SGPT ( Alanine Aminotrasferase) --> Not done
Labs.DLAlatSgptOther Result in other unit for blood chemistry ALAT/SGPT Preferred unit for ALAT/SGPT was U/L. When sites used another unit, the value was recorded here.
Labs.DLAlatSgptOtherUnit Other unit (than standard) used for blood chemistry ALAT/SGPT Not Done Preferred unit for ALAT/SGPT was U/L. When sites used another unit, the other unit was recorded here.
Labs.DLAlatSgptUL ALAT/SGPT (Alanine Aminotrasferase) level BLOOD CHEMISTRY --> ALAT/SGPT Recorded in "preferred" units (U/L)
Labs.DLAlbumingL Albumin level BLOOD CHEMISTRY --> Albumin Recorded in "preferred" units (g/dL)
Labs.DLAlbuminNotDone Blood chemistry Albumin Not Done BLOOD CHEMISTRY --> Albumin --> Not done
Labs.DLAlbuminOther Result in other unit for blood chemistry Albumin Preferred unit for Albumin was g/L. When sites used another unit, the value was recorded here.
Labs.DLAlbuminOtherUnit Other unit (than standard) used for blood chemistry Albumin Preferred unit for Albumin was g/L. When sites used another unit, the other unit was recorded here.
Labs.DLAlkalinePhosphataseNotDone Blood chemistry Alkaline Phosphatase Not Done BLOOD CHEMISTRY --> Alkaline Phosphatase --> Not done
Labs.DLAlkalinePhosphataseOther Result in other unit for blood chemistry Alkaline Phosphatase Preferred unit for Alkaline Phosphatase was U/L. When sites used another unit, the value was recorded here.
Labs.DLAlkalinePhosphataseOtherUnit Other unit (than standard) used for blood chemistry Alkaline Phosphatase Preferred unit for Alkaline Phosphatase was U/L. When sites used another unit, the other unit was recorded here.
Labs.DLAlkalinePhosphataseUL Alkaline Phosphatase level BLOOD CHEMISTRY --> Alkaline Phosphatase Recorded in "preferred" units (U/L)
Labs.DLAmylaseNotDone Blood chemistry Amylase Not Done BLOOD CHEMISTRY --> Amylase --> Not done
Labs.DLAmylaseOther Result in other unit for blood chemistry Amylase Preferred unit for Amylase was U/L. When sites used another unit, the value was recorded here.
Labs.DLAmylaseOtherUnit Other unit (than standard) used for blood chemistry Amylase Preferred unit for Amylase was U/L. When sites used another unit, the other unit was recorded here.
Labs.DLAmylaseUL Amylase level BLOOD CHEMISTRY --> Amylase Recorded in "preferred" units (U/L)
Labs.DLaPttNotDone Haematology aPTT Not Done HAEMATOLOGY --> Activated thromboplastine time (aPTT) --> Not done
Labs.DLaPttOther Result in other unit for Haematology aPTT Preferred unit for aPTT was sec. When sites used another unit, the value was recorded here.
Labs.DLaPttOtherUnit Other unit (than standard) used for Haematology aPTT Preferred unit for aPTT was sec. When sites used another unit, the other unit was recorded here.
Labs.DLaPttsec aPTT (Activated Thromboplastine Time) level HAEMATOLOGY --> Activated thromboplastine time (aPTT) Recorded in "preferred" units (sec.)
Labs.DLAsatSgotNotDone Blood chemistry ASAT/SGOT Not Done BLOOD CHEMISTRY --> ASAT/SGOT --> Not done
Labs.DLAsatSgotOther Result in other unit for blood chemistry ASAT/SGOT Preferred unit for ASAT/SGOT was U/L. When sites used another unit, the value was recorded here.
Labs.DLAsatSgotOtherUnit Other unit (than standard) used for blood chemistry ASAT/SGOT Preferred unit for ASAT/SGOT was U/L. When sites used another unit, the other unit was recorded here.
Labs.DLAsatSgotUL ASAT/SGOT (Aspartate Aminotrasferase) level BLOOD CHEMISTRY --> ASAT/SGOT Recorded in "preferred" units (U/L)
Labs.DLASPIAggreg Aggregation measured from ASPI test Only applicable to sites doing multiplate studies. MULTIPLATE TEST --> ASPI Test --> Aggregation
Labs.DLASPIAUC AUC measured from ASPI test Only applicable to sites doing multiplate studies
Labs.DLASPIAUCU Multiplate ASPI test AUC in U Only applicable to sites doing multiplate studies MULTIPLATE TEST --> ASPI Test --> AUC (U)
Labs.DLASPIVelocity Velocity measured from ASPI test Only applicable to sites doing multiplate studies MULTIPLATE TEST --> ASPI Test --> Velocity (AU*min)
Labs.DLBloodChemDone Blood Chemistry Done Reflects if Blood chemistry was done.
Labs.DLCalciummmolL Calcium level BLOOD CHEMISTRY --> Calcium Recorded in "preferred" units (mmol/L)
Labs.DLCalciumNotDone Blood chemistry Calcium Not Done BLOOD CHEMISTRY --> Calcium --> Not done
Labs.DLCalciumOther Result in other unit for blood chemistry Calcium Preferred unit for Calcium was mmol/L. When sites used another unit, the value was recorded here.
Labs.DLCalciumOtherUnit Other unit (than standard) used for blood chemistry Calcium Preferred unit for Calcium was mmol/L. When sites used another unit, the other unit was recorded here.
Labs.DLCFTExtem CFT (Clot Formation Time) measured from EXTEM test Only applicable to sites doing ROTEM studies. ROTEM --> CFT --> EXTEM
Labs.DLCFTFibtem CFT (Clot Formation Time) measured from FIBTEM test Only applicable to sites doing ROTEM studies. ROTEM --> CFT --> FIBTEM
Labs.DLCFTNotDone ROTEM CFT labs Not Done Only applicable to sites doing ROTEM studies. ROTEM --> CFT --> Not Done
Labs.DLCL30 CL30 (Clot Lysis at 30 minutes) Only applicable to sites doing ROTEM/TEG studies. TEG --> CL30
Labs.DLCL30NotDone TEG CL30 labs Not Done Only applicable to sites doing ROTEM/TEG studies. TEG --> CL30 --> Not Done
Labs.DLCL60 CL60 (Clot Lysis at 60 minutes) Only applicable to sites doing ROTEM/TEG studies. TEG --> CL60
Labs.DLCL60NotDone TEG CL60 labs Not Done Only applicable to sites doing ROTEM/TEG studies. TEG --> CL60 --> Not Done
Labs.DLCLTExtem CLT (Clot Lysis Time) measured from EXTEM test Only applicable to sites doing ROTEM studies ROTEM --> CLT --> EXTEM
Labs.DLCLTFibtem CLT (Clot Lysis Time) measured from FIBTEM test Only applicable to sites doing ROTEM studies ROTEM --> CLT --> FIBTEM
Labs.DLCLTNotDone ROTEM CLT labs Not Done Only applicable to sites doing ROTEM studies ROTEM --> CLT --> Not Done
Labs.DLCOLAggreg Aggregation measured from COL (Collagen) test Only applicable to sites doing multiplate studies MULTIPLATE TEST --> COL Test --> Aggregation
Labs.DLCOLAUC AUC measured from COL (Collagen) test Only applicable to sites doing multiplate studies MULTIPLATE TEST --> COL Test --> AUC (AU*min)
Labs.DLCOLAUCU Multiplate COL test AUC in U Only applicable to sites doing multiplate studies MULTIPLATE TEST --> COL Test --> AUC (U)
Labs.DLCOLVelocity Velocity measured from COL (Collagen) test Only applicable to sites doing multiplate studies MULTIPLATE TEST --> COL Test --> Velocity (AU*min)
Labs.DLCreatinineNotDone Blood chemistry Creatinine Not Done BLOOD CHEMISTRY --> Creatinine --> Not done
Labs.DLCreatinineOther Result in other unit for blood chemistry Creatinine Preferred unit for Creatinine was µmol/L. When sites used another unit, the value was recorded here.
Labs.DLCreatinineOtherUnit Other unit (than standard) used for blood chemistry Creatinine Preferred unit for Creatinine was µmol/L. When sites used another unit, the other unit was recorded here.
Labs.DLCreatinineumolL Creatinine level BLOOD CHEMISTRY --> Creatinine Recorded in "preferred" units (µmol/L)
Labs.DLCRPmgL CRP (C-reactive Protein) level HAEMATOLOGY --> C-reactive protein (CRP) Recorded in "preferred" units (mg/L)
Labs.DLCRPNotDone Haematology CRP Not Done HAEMATOLOGY --> C-reactive protein (CRP) --> Not done
Labs.DLCRPOther Result in other unit for Haematology CRP Preferred unit for CRP was mg/L. When sites used another unit, the value was recorded here.
Labs.DLCRPOtherUnit Other unit (than standard) used for Haematology CRP Preferred unit for CRP was mg/L. When sites used another unit, the other unit was recorded here.
Labs.DLCTExtem CT (Clotting Time) measured from EXTEM test Only applicable to sites doing ROTEM studies ROTEM --> CT --> EXTEM
Labs.DLCTFibtem CT (Clotting Time) measured from FIBTEM test Only applicable to sites doing ROTEM studies ROTEM --> CT --> FIBTEM
Labs.DLCTNotDone ROTEM CT labs Not Done Only applicable to sites doing ROTEM studies ROTEM --> CT --> Not Done
Labs.DLDate Date of lab testing Date of labs
Labs.DLDdimersNotDone Haematology D-dimers Not Done HAEMATOLOGY --> D-dimers --> Not done
Labs.DLDdimersOther Result in other unit for Haematology D-dimers Preferred unit for D-dimers was µg/L. When sites used another unit, the value was recorded here.
Labs.DLDdimersOtherUnit Other unit (than standard) used for Haematology D-dimers Preferred unit for D-dimers was µg/L. When sites used another unit, the other unit was recorded here.
Labs.DLDdimersugL D-dimers level HAEMATOLOGY --> D-dimers Recorded in "preferred" units ( µg/L)
Labs.DLEosinophilsNotDone Haematology Eosinophils Not Done HAEMATOLOGY --> Eosinophils --> Not done
Labs.DLEosinophilsOther Result in other unit for Haematology Eosinophils Preferred unit for Eosinophils was %. When sites used another unit, the value was recorded here.
Labs.DLEosinophilsOtherUnit Other unit (than standard) used for Haematology Eosinophils Preferred unit for Eosinophils was %. When sites used another unit, the other unit was recorded here.
Labs.DLEosinophilspct Eosinophils level HAEMATOLOGY --> Eosinophils Recorded in "preferred" units (%)
Labs.DLEPL EPL (Estimated Percent Lysis) Only applicable to sites doing TEG/ROTEM studies TEG --> EPL
Labs.DLEPLNotDone TEG EPL Labs Not Done Only applicable to sites doing TEG/ROTEM studies TEG --> EPL--> Not Done
Labs.DLFibrinogenmgdL Fibrinogen level HAEMATOLOGY --> Fibrinogen Recorded in "preferred" units (mg/dL)
Labs.DLFibrinogenNotDone Haematology Fibrinogen Not Done HAEMATOLOGY --> Fibrinogen --> Not done
Labs.DLFibrinogenOther Result in other unit for Haematology Fibrinogen Preferred unit for Fibrinogen was mg/dL. When sites used another unit, the value was recorded here.
Labs.DLFibrinogenOtherUnit Other unit (than standard) used for Haematology Fibrinogen Preferred unit for Fibrinogen was mg/dL. When sites used another unit, the other unit was recorded here.
Labs.DLGlucosemmolL Glucose level BLOOD CHEMISTRY --> Glucose Recorded in "preferred" units (mmol/L)
Labs.DLGlucoseNotDone Blood chemistry Glucose Not Done BLOOD CHEMISTRY --> Glucose --> Not done
Labs.DLGlucoseOther Result in other unit for blood chemistry Glucose Preferred unit for Glucose was mmol/L. When sites used another unit, the value was recorded here.
Labs.DLGlucoseOtherUnit Other unit (than standard) used for blood chemistry Glucose Preferred unit for Glucose was mmol/L. When sites used another unit, the other unit was recorded here.
Labs.DLHaematologyDone Haematology labs done Reflects if Haematology labs was done
Labs.DLHematocritNotDone Haematology Hematocrit Not Done HAEMATOLOGY --> Hematocrit --> Not done
Labs.DLHematocritOther Result in other unit for Haematology Hematocrit Preferred unit for Hematocrit was %. When sites used another unit, the value was recorded here.
Labs.DLHematocritOtherUnit Other unit (than standard) used for Haematology Hematocrit Preferred unit for Hematocrit was %. When sites used another unit, the other unit was recorded here.
Labs.DLHematocritpct Hematocrit level HAEMATOLOGY --> Hematocrit Recorded in "preferred" units (%)
Labs.DLHemoglobingdL Haemoglobin level HAEMATOLOGY --> Hemoglobin Recorded in "preferred" units (g/dL)
Labs.DLHemoglobinNotDone Haematology Hemoglobin Not Done HAEMATOLOGY --> Hemoglobin --> Not done
Labs.DLHemoglobinOther Result in other unit for Haematology Hemoglobin Preferred unit for Hemoglobin was g/dL. When sites used another unit, the value was recorded here.
Labs.DLHemoglobinOtherUnit Other unit (than standard) used for Haematology Hemoglobin Preferred unit for Hemoglobin was g/dL. When sites used another unit, the other unit was recorded here.
Labs.DLInr INR (International Normalized Ratio) level HAEMATOLOGY --> INR
Labs.DLInrNotDone Haematology INR Not Done HAEMATOLOGY --> INR --> Not done
Labs.DLInrOther Result in other unit for Haematology INR INR results if other units used than standard
Labs.DLInrOtherUnit Other unit (than standard) used for Haematology INR INR results if other units used than standard
Labs.DLK K value Only applicable to sites doing TEG/ROTEM studies TEG --> K
Labs.DLKNotDone TEG K-value not done Only applicable to sites doing TEG/ROTEM studies TEG --> K--> Not Done
Labs.DLLabsNotDone Hospital labs not done Reflects when hospital labs were not done
Labs.DLLabsNotDoneOther Reason why hospital labs not done Specifies the reason why hospital labs were not done
Labs.DLLdhNotDone Blood chemistry LDH (Lactate Dehydrogenase) Not Done BLOOD CHEMISTRY --> LDH (Lactate Dehydrogenase) --> Not done
Labs.DLLdhOther Result in other unit for Blood chemistry LDH (Lactate Dehydrogenase) Preferred unit for LDH was U/L. When sites used another unit, the value was recorded here.
Labs.DLLdhOtherUnit Other unit (than standard) used for Blood chemistry LDH (Lactate Dehydrogenase) Preferred unit for LDH was U/L. When sites used another unit, the other unit was recorded here.
Labs.DLLdhUL LDH (Lactate Dehydrogenase) level BLOOD CHEMISTRY --> LDH (Lactate Dehydrogenase) Recorded in "preferred" units (U/L)
Labs.DLLY30Extem LI30 (Lysis Index after 30 minutes) measured from EXTEM test Only applicable to sites doing ROTEM studies ROTEM --> LY30 --> EXTEM
Labs.DLLY30Fibtem LI30 (Lysis Index after 30 minutes) measured from FIBTEM test Only applicable to sites doing ROTEM studies ROTEM --> LY30 --> FIBTEM
Labs.DLLY30NotDone ROTEM LY30 Not Done Only applicable to sites doing ROTEM studies ROTEM --> LY30 --> Not Done
Labs.DLLY60Extem LI60 (Lysis Index after 60 minutes) measured from EXTEM test Only applicable to sites doing ROTEM studies ROTEM --> LY60 --> EXTEM
Labs.DLLY60Fibtem LI60 (Lysis Index after 60 minutes) measured from FIBTEM test Only applicable to sites doing ROTEM studies ROTEM --> LY60 --> FIBTEM
Labs.DLLY60NotDone ROTEM LY60 Not Done Only applicable to sites doing ROTEM studies ROTEM --> LY60 --> Not Done
Labs.DLLymphocytesNotDone Haematology Lymphocytes Not Done HAEMATOLOGY --> Lymphocytes --> Not done
Labs.DLLymphocytesOther Result in other unit for Haematology Lymphocytes Preferred unit for Lymphocytes was %. When sites used another unit, the value was recorded here.
Labs.DLLymphocytesOtherUnit Other unit (than standard) used for Haematology Lymphocytes Preferred unit for Lymphocytes was %. When sites used another unit, the other unit was recorded here.
Labs.DLLymphocytespct Lymphocytes level HAEMATOLOGY --> Lymphocytes Recorded in "preferred" units (%)
Labs.DLMA MA (Maximum Amplitude) Only applicable to sites doing TEG/ROTEM studies TEG --> MA
Labs.DLMagnesiummmolL Magnesium level BLOOD CHEMISTRY --> Magnesium Recorded in "preferred" units (mmol/L)
Labs.DLMagnesiumNotDone Blood chemistry Magnesium Not Done BLOOD CHEMISTRY --> Magnesium --> Not done
Labs.DLMagnesiumOther Result in other unit for blood chemistry Magnesium Preferred unit for Magnesium was mmol/L. When sites used another unit, the value was recorded here.
Labs.DLMagnesiumOtherUnit Other unit (than standard) used for blood chemistry Magnesium Preferred unit for Magnesium was mmol/L. When sites used another unit, the other unit was recorded here.
Labs.DLMANotDone TEG MA Not Done Only applicable to sites doing TEG/ROTEM studies TEG --> MA --> Not Done
Labs.DLMCFExtem MCF (Maximum Clot Firmness) measured from EXTEM test Only applicable to sites doing ROTEM studies ROTEM --> MCF --> EXTEM
Labs.DLMCFFibtem MCF (Maximum Clot Firmness) measured from FIBTEM test Only applicable to sites doing ROTEM studies ROTEM --> MCF --> FIBTEM
Labs.DLMCFNotDone ROTEM MCF Not Done Only applicable to sites doing ROTEM studies ROTEM --> MCF --> Not Done
Labs.DLMCFtExtem MCF-t (Time to Maximum Clot Firmness) measured from EXTEM test Only applicable to sites doing ROTEM studies ROTEM --> MCF-t --> EXTEM
Labs.DLMCFtFibtem MCF-t (Time to Maximum Clot Firmness) measured from FIBTEM test Only applicable to sites doing ROTEM studies ROTEM --> MCF-t --> FIBTEM
Labs.DLMCFtNotDone ROTEM MCF-t Not Done Only applicable to sites doing ROTEM studies ROTEM --> MCF-t --> Not Done
Labs.DLMLExtem ML (Maximum Lysis) measured from EXTEM test Only applicable to sites doing ROTEM studies ROTEM --> ML --> EXTEM
Labs.DLMLFibtem ML (Maximum Lysis) measured from FIBTEM test Only applicable to sites doing ROTEM studies ROTEM --> ML --> FIBTEM
Labs.DLMLNotDone ROTEM ML Not Done Only applicable to sites doing ROTEM studies ROTEM --> ML --> Not Done
Labs.DLMultiplateDone Multiplate Labs Not Done Reflects if Multiplate was done - Only in selected sites
Labs.DLNeutrophilsNotDone Haematology Neutrophils Not Done HAEMATOLOGY --> Neutrophils --> Not done
Labs.DLNeutrophilsOther Result in other unit for Haematology Neutrophils Preferred unit for Neutrophils was %. When sites used another unit, the value was recorded here.
Labs.DLNeutrophilsOtherUnit Other unit (than standard) used for Haematology Neutrophils Preferred unit for Neutrophils was %. When sites used another unit, the other unit was recorded here.
Labs.DLNeutrophilspct Neutrophils level HAEMATOLOGY --> Neutrophils Recorded in "preferred" units (%)
Labs.DLPlatelet10_5L Platelet count HAEMATOLOGY --> Platelet Recorded in "preferred" units (X10^9/L or X10^3/µL)
Labs.DLPlateletNotDone Haematology Platelet Not Done HAEMATOLOGY --> Platelet --> Not done
Labs.DLPlateletOther Result in other unit for Haematology Platelet Preferred unit for Platelet was X10^9/L or X10^3/μL. When sites used another unit, the value was recorded here.
Labs.DLPlateletOtherUnit Other unit (than standard) used for Haematology Platelet Preferred unit for Platelet was X10^9/L or X10^3/μL. When sites used another unit, the other unit was recorded here.
Labs.DLPotassiummmolL Potassium level BLOOD CHEMISTRY --> Potassium Recorded in "preferred" units (mmol/L)
Labs.DLPotassiumNotDone Blood chemistry Potassium Not Done BLOOD CHEMISTRY --> Potassium --> Not done
Labs.DLPotassiumOther Result in other unit for Blood chemistry Potassium Preferred unit for Potassium was mmol/L. When sites used another unit, the value was recorded here.
Labs.DLPotassiumOtherUnit Other unit (than standard) used for Blood chemistry Potassium Preferred unit for Potassium was mmol/L. When sites used another unit, the other unit was recorded here.
Labs.DLProthrombineTimeNotDone Haematology Prothrombine Time Not Done HAEMATOLOGY --> Prothrombine Time --> Not done
Labs.DLProthrombineTimeOther Result in other unit for Haematology Prothrombine Time Preferred unit for Prothrombine Time was sec. When sites used another unit, the value was recorded here.
Labs.DLProthrombineTimeOtherUnit Other unit (than standard) used for Haematology Prothrombine Time Preferred unit for Prothrombine Time was sec. When sites used another unit, the other unit was recorded here.
Labs.DLProthrombineTimeSec PT (Prothrombine Time) level HAEMATOLOGY --> Prothrombine Time Recorded in "preferred" units (sec.)
Labs.DLR R value (Reaction time) Only applicable to sites doing TEG/ROTEM studies TEG --> R
Labs.DLRISTOAggreg Aggregation measured from RISTO (Ristocetin) test Only applicable to sites doing multiplate studies MULTIPLATE TEST --> RISTO Test --> Aggregation
Labs.DLRISTOAUC AUC measured from RISTO (Ristocetin) test Only applicable to sites doing multiplate studies MULTIPLATE TEST --> RISTO Test --> AUC (AU*min)
Labs.DLRISTOAUCU Multiplate RISTO test AUC in U Only applicable to sites doing multiplate studies MULTIPLATE TEST --> RISTO Test --> AUC (U)
Labs.DLRISTOVelocity Velocity measured from RISTO (Ristocetin) test Only applicable to sites doing multiplate studies MULTIPLATE TEST --> RISTO Test --> Velocity (AU*min)
Labs.DLRNotDone TEG R Labs Not Done Only applicable to sites doing TEG studies TEG --> R --> Not Done
Labs.DLROTEMDone ROTEM labs Done Reflects if ROTEM was done - Only applicable to sites doing ROTEM tests
Labs.DLS100BNotDone Blood chemistry S100B Not Done BLOOD CHEMISTRY --> S100B --> Not done
Labs.DLS100BOther Result in other unit for Blood chemistry S100B Preferred unit for S100B was µg/L. When sites used another unit, the value was recorded here.
Labs.DLS100BOtherUnit Other unit (than standard) used for Blood chemistry S100B Preferred unit for S100B was µg/L. When sites used another unit, the other unit was recorded here.
Labs.DLS100BugL S100B level BLOOD CHEMISTRY --> S100B Recorded in "preferred" units (µg/L)
Labs.DLSodiummmolL Sodium level BLOOD CHEMISTRY --> Sodium Recorded in "preferred" units (mmol/L)
Labs.DLSodiumNotDone Blood chemistry Sodium Not Done BLOOD CHEMISTRY --> Sodium --> Not done
Labs.DLSodiumOther Result in other unit for Blood chemistry Sodium Preferred unit for Sodium mmol/L. When sites used another unit, the value was recorded here.
Labs.DLSodiumOtherUnit Other unit (than standard) used for Blood chemistry Sodium Preferred unit for Sodium mmol/L. When sites used another unit, the other unit was recorded here.
Labs.DLTEGA10 A10 (Amplitude/clot firmness at 10 minutes) Only applicable for sites doing TEG TEG --> A10
Labs.DLTEGA10NotDone TEG A10 Labs not Done Only applicable for sites doing TEG TEG --> A10 --> Not Done
Labs.DLTEGA5 A5 (Amplitude/clot firmness at 5 minutes) Only applicable for sites doing TEG TEG --> A5
Labs.DLTEGA5NotDone TEG A5 Labs not Done Only applicable for sites doing TEG TEG --> A5 --> Not Done
Labs.DLTEGaAngle alpha-angle Only applicable for sites doing TEG TEG --> α-angle
Labs.DLTEGaAngleNotDone TEG α-angle labs Not Done Only applicable for sites doing TEG TEG --> α-angle --> Not Done
Labs.DLTEGDone TEG Labs Done Reflects if TEG was done - Only applicable for selected sites doing TEG
Labs.DLTEGType TEG (Thromboelastography) type Reflects type of TEG done - Only applicable for selected sites doing TEG
Labs.DLTime Time of lab testing Time of labs
Labs.DLTMA TMA (Time to Maximum Amplitude) Only applicable for sites doing TEG TEG --> TMA
Labs.DLTMANotDone TEG TMA labs Not Done Only applicable for sites doing TEG TEG --> TMA --> Not Done
Labs.DLTotalBilirubinNotDone Blood chemistry Total Bilirubin Not Done BLOOD CHEMISTRY --> Total Bilirubin --> Not done
Labs.DLTotalBilirubinOther Result in other unit for Blood chemistry Total Bilirubin Preferred unit for Total Bilirubin was µmol/L. When sites used another unit, the value was recorded here.
Labs.DLTotalBilirubinOtherUnit Other unit (than standard) used for Blood chemistry Total Bilirubin Preferred unit for Total Bilirubin was µmol/L. When sites used another unit, the other unit was recorded here.
Labs.DLTotalBilirubinumolL Total Bilirubin level BLOOD CHEMISTRY --> Total Bilirubin Recorded in "preferred" units (µmol/L)
Labs.DLToxScreen Result of toxic drug screen test Toxic Drug Screen Result Only if performed as part of clinical routine
Labs.DLToxScreenDone Toxic drug screen done Reflects if Toxic Drug Screen was done. Only if performed as part of clinical routine.
Labs.DLToxScreenPosAmphet Positive for Amphetamines Reflects if Toxic Drug Screen was positive for Amphetamines. Only if performed as part of clinical routine.
Labs.DLToxScreenPosBarb Positive for Barbiturates Reflects if Toxic Drug Screen was positive for Barbiturates. Only if performed as part of clinical routine.
Labs.DLToxScreenPosBenzo Positive for Benzodiazepines Reflects if Toxic Drug Screen was positive for Benzodiazepines. Only if performed as part of clinical routine.
Labs.DLToxScreenPosCannabis Positive for Cannabinoids Reflects if Toxic Drug Screen was positive for Cannabinoids. Only if performed as part of clinical routine.
Labs.DLToxScreenPosCocaine Positive for Cocaine Reflects if Toxic Drug Screen was positive for Cocaine. Only if performed as part of clinical routine.
Labs.DLToxScreenPosMeth Positive for Methadone Reflects if Toxic Drug Screen was positive for Methadone. Only if performed as part of clinical routine.
Labs.DLToxScreenPosMethaqual Positive for Methaqualone Reflects if Toxic Drug Screen was positive for Methaqualone. Only if performed as part of clinical routine.
Labs.DLToxScreenPosOpiate Positive for Opiates Reflects if Toxic Drug Screen was positive for Opiates. Only if performed as part of clinical routine.
Labs.DLToxScreenPosOther Positive for other drugs Reflects if Toxic Drug Screen was positive for Other drugs than the predefined list. Only if performed as part of clinical routine.
Labs.DLToxScreenPosOtherTxt Positive for other drugs (please specify) Specifies for which drugs, if Toxic Drug Screen was positive for Other drugs than the predefined list. Only if performed as part of clinical routine.
Labs.DLToxScreenPosPhency Positive for Phencyclidine Reflects if Toxic Drug Screen was positive for Phencyclidine. Only if performed as part of clinical routine.
Labs.DLToxScreenType Type of sample used in toxic drug screen test Specifies the type of sample, Urine or Serum, if Toxic Drug Screen was performed. Only if performed as part of clinical routine.
Labs.DLTRAPAggreg Aggregation measured from TRAP (Thrombin Receptor Activating Peptide) test Only applicable to sites doing multiplate studies. MULTIPLATE TEST --> TRAP Test --> Aggregation
Labs.DLTRAPAUC AUC measured from TRAP (Thrombin Receptor Activating Peptide) test Only applicable to sites doing multiplate studies. MULTIPLATE TEST --> TRAP Test --> AUC (AU*min)
Labs.DLTRAPAUCU Multiplate TRAP test AUC in U Only applicable to sites doing multiplate studies. MULTIPLATE TEST --> TRAP Test --> AUC (U)
Labs.DLTRAPVelocity Velocity measured from TRAP (Thrombin Receptor Activating Peptide) test Only applicable to sites doing multiplate studies. MULTIPLATE TEST --> TRAP Test --> Velocity (AU*min)
Labs.DLTTL TTL (Time To Lysis) Only applicable to sites doing TEG studies TEG --> TTL
Labs.DLTTLNotDone TEG TTL Labs not Done Only applicable to sites doing TEG studies TEG --> TTL --> Not Done
Labs.DLUreammolL Urea level BLOOD CHEMISTRY --> Urea Recorded in "preferred" units (mmol/L)
Labs.DLUreaNotDone Blood chemistry Urea Not Done BLOOD CHEMISTRY --> Urea --> Not done
Labs.DLUreaOther Result in other unit for Blood chemistry Urea Preferred unit for Urea was mmol/L. When sites used another unit, the value was recorded here.
Labs.DLUreaOtherUnit Other unit (than standard) used for Blood chemistry Urea Preferred unit for Urea was mmol/L. When sites used another unit, the other unit was recorded here.
Labs.DLWhiteBloodCellNotDone Blood chemistry White Blood cell Not Done HAEMATOLOGY --> White blood cell --> Not done
Labs.DLWhiteBloodCellOther Result in other unit for Blood White Blood cell Preferred unit for White Blood Cell was X10^9/L or X10^3/μL. When sites used another unit, the value was recorded here.
Labs.DLWhiteBloodCellOtherUnit Other unit (than standard) used for Blood White Blood cell Preferred unit for White Blood Cell was X10^9/L or X10^3/μL. When sites used another unit, the other unit was recorded here.
Labs.DLWhiteBloodCellpct WBC (White Blood Cell) count HAEMATOLOGY --> White blood cell Recorded in "preferred" units (X10^9/L or X10^3/μL)
LabSampling.LSBiomarkersCollctnDate Date of collection of blood samples for biomarkers status This reflects the biomarker sampling collection date. Protein biomarker sampling was planned in all subjects. 1 x 9ml blood sample was collected in a serum separator tube. After 45 minutes (±15) of coagulation at room temperature, it is centrifuged at 1500g for 10 minutes, 8 x 0.5ml of serum is then aliquoted into barcoded 1.8 ml blue capped cryovials. Note: not available for all subjects - Blood sampling required specific informed consent, but this was not provided by all subjects, and in others biomarker collection was not possible for logistic reasons.
LabSampling.LSBiomarkersCollctnTime Time of collection of blood samples for biomarkers status This reflects the biomarker sampling collection time. Protein biomarker sampling was planned in all subjects. 1 x 9ml blood sample was collected in a serum separator tube. After 45 minutes (±15) of coagulation at room temperature, it is centrifuged at 1500g for 10 minutes, 8 x 0.5ml of serum is then aliquoted into barcoded 1.8 ml blue capped cryovials. Note: not available for all subjects - Blood sampling required specific informed consent, but this was not provided by all subjects, and in others biomarker collection was not possible for logistic reasons.
LabSampling.LSBiomarkersFreezerCollctnDate Date blood samples are stored in the freezer for biomarkers status This reflects the biomarker freezer date. Protein biomarker sampling was planned in all subjects. 1 x 9ml blood sample was collected in a serum separator tube. After 45 minutes (±15) of coagulation at room temperature, it is centrifuged at 1500g for 10 minutes, 8 x 0.5ml of serum is then aliquoted into barcoded 1.8 ml blue capped cryovials. Note: not available for all subjects - Blood sampling required specific informed consent, but this was not provided by all subjects, and in others biomarker collection was not possible for logistic reasons.
LabSampling.LSBiomarkersFreezerCollctnTime Time blood samples are stored in the freezer for biomarkers status This reflects the biomarker freezer time. Protein biomarker sampling was planned in all subjects. 1 x 9ml blood sample was collected in a serum separator tube. After 45 minutes (±15) of coagulation at room temperature, it is centrifuged at 1500g for 10 minutes, 8 x 0.5ml of serum is then aliquoted into barcoded 1.8 ml blue capped cryovials. Note: not available for all subjects - Blood sampling required specific informed consent, but this was not provided by all subjects, and in others biomarker collection was not possible for logistic reasons.
LabSampling.LSBiomarkersNotCollReason Reason for not collecting blood samples for biomarkers status 1 == No informed consent
2 == Blood draw not successful
3 == Logistic reasons
This specifies the reason why biomarker sampling was not obtained.
LabSampling.LSBloodTransBfSampl Did the patient receive blood transfusion before sampling? 0 == No
1 == Yes
99 == Unknown
Reflects if the patient received a blood transfusion before blood sampling
LabSampling.LSCoagulationCollctnDate Date of collection of blood samples for coagulation status This reflects the Coagulation sampling collection date. Central haemostasis investigations were complementary to routine tests performed by local laboratories at participating sites and were performed only in selected centers. This involved the collection of blood into: 1 x 2.7 ml potassium EDTA tube and 1 x 10 ml and 1 x 5 ml sodium-citrate tubes at the enrollment time points for a limited number of subjects from the Admission and ICU stratum. Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU subjects (at this sampling point no potassium EDTA tubes/samples were requested).
LabSampling.LSCoagulationCollctnTime Time of collection of blood samples for coagulation status This reflects the Coagulation sampling collection time. Central haemostasis investigations were complementary to routine tests performed by local laboratories at participating sites and were performed only in selected centers. This involved the collection of blood into: 1 x 2.7 ml potassium EDTA tube and 1 x 10 ml and 1 x 5 ml sodium-citrate tubes at the enrollment time points for a limited number of subjects from the Admission and ICU stratum. Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU subjects (at this sampling point no potassium EDTA tubes/samples were requested).
LabSampling.LSCoagulationFreezerDate Date blood samples are stored in the freezer for coagulation status This reflects the Coagulation sampling freezer date. Central haemostasis investigations were complementary to routine tests performed by local laboratories at participating sites and were performed only in selected centers. This involved the collection of blood into: 1 x 2.7 ml potassium EDTA tube and 1 x 10 ml and 1 x 5 ml sodium-citrate tubes at the enrollment time points for a limited number of subjects from the Admission and ICU stratum. Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU subjects (at this sampling point no potassium EDTA tubes/samples were requested).
LabSampling.LSCoagulationFreezerTime Time blood samples are stored in the freezer for coagulation status This reflects the Coagulation sampling freezer time. Central haemostasis investigations were complementary to routine tests performed by local laboratories at participating sites and were performed only in selected centers. This involved the collection of blood into: 1 x 2.7 ml potassium EDTA tube and 1 x 10 ml and 1 x 5 ml sodium-citrate tubes at the enrollment time points for a limited number of subjects from the Admission and ICU stratum. Post-op samples and Day 2 samples were also obtained in the same two sodium citrate tubes from a limited number of ICU subjects (at this sampling point no potassium EDTA tubes/samples were requested).
LabSampling.LSGeneticCollctnDate Date of collection of blood samples for genetic analyses This reflects the Genetic sampling collection date. Two genetic samples should be obtained in all CENTER-TBI participants. It is recognized by the CENTER-TBI coordinators that obtaining genetic samples post transfusion could result in “chimerism” in the genotype and that this could persists for long periods after trauma. However, the coordinators have taken a pragmatic view that samples should be taken at baseline when taking biomarker samples (+/- coagulation samples for those sites in the sub-study). This pragmatic approach has numerous advantages; it limits the complexity of the sampling regimen, reduces the need for repeat venepunctures and minimises the risk of missed samples if the participant is lost to follow-up. Accurate documentation of the participant’s transfusion status is essential for future analysis. In some cases, blood sampling for genetic analysis were obtained later.
LabSampling.LSGeneticCollctnTime Time of collection of blood samples for genetic analyses This reflects the Genetic sampling collection time. Two genetic samples should be obtained in all CENTER-TBI participants. It is recognized by the CENTER-TBI coordinators that obtaining genetic samples post transfusion could result in “chimerism” in the genotype and that this could persists for long periods after trauma. However, the coordinators have taken a pragmatic view that samples should be taken at baseline when taking biomarker samples (+/- coagulation samples for those sites in the sub-study). This pragmatic approach has numerous advantages; it limits the complexity of the sampling regimen, reduces the need for repeat venepunctures and minimises the risk of missed samples if the participant is lost to follow-up. Accurate documentation of the participant’s transfusion status is essential for future analysis. In some cases, blood sampling for genetic analysis were obtained later.
LabSampling.LSGeneticFreezerDate Date blood samples are stored in the freezer for genetic analyses This reflects the Genetic sampling freezer date. Two genetic samples should be obtained in all CENTER-TBI participants. It is recognized by the CENTER-TBI coordinators that obtaining genetic samples post transfusion could result in “chimerism” in the genotype and that this could persists for long periods after trauma. However, the coordinators have taken a pragmatic view that samples should be taken at baseline when taking biomarker samples (+/- coagulation samples for those sites in the sub-study). This pragmatic approach has numerous advantages; it limits the complexity of the sampling regimen, reduces the need for repeat venepunctures and minimises the risk of missed samples if the participant is lost to follow-up. Accurate documentation of the participant’s transfusion status is essential for future analysis. In some cases, blood sampling for genetic analysis were obtained later.
LabSampling.LSGeneticFreezerTime Time blood samples are stored in the freezer for genetic analyses This reflects the Genetic sampling freezer time. Two genetic samples should be obtained in all CENTER-TBI participants. It is recognized by the CENTER-TBI coordinators that obtaining genetic samples post transfusion could result in “chimerism” in the genotype and that this could persists for long periods after trauma. However, the coordinators have taken a pragmatic view that samples should be taken at baseline when taking biomarker samples (+/- coagulation samples for those sites in the sub-study). This pragmatic approach has numerous advantages; it limits the complexity of the sampling regimen, reduces the need for repeat venepunctures and minimises the risk of missed samples if the participant is lost to follow-up. Accurate documentation of the participant’s transfusion status is essential for future analysis. In some cases, blood sampling for genetic analysis were obtained later.
LabSampling.LSGeneticNotCollReason Reason for not collecting blood samples for genetic analyses 1 == No informed consent
2 == Blood draw not successful
3 == Logistic reasons
This reflects the reason why Genetic sampling was not obtained.
LabSampling.LSHospitalCollctnDate Date of collection of blood samples for hospital lab This reflects the blood sampling collection date for routine hospital labs. Sites were requested to document results of all routinely performed lab assessments at baseline, including where possible/applicable point-of-care testing. For patients with multiple labs at different times during the day, a new Lab form was created for each collection
LabSampling.LSHospitalCollctnTime Time of collection of blood samples for hospital lab This reflects the blood sampling collection time for routine hospital labs. Sites were requested to document results of all routinely performed lab assessments at baseline, including where possible/applicable point-of-care testing. For patients with multiple labs at different times during the day, a new Lab form was created for each collection
LabSampling.LSPointOfCareCollctnDate Date of collection of blood samples for point of care testing Reflects the date for Point of care testing.
LabSampling.LSPointOfCareCollctnTime Time of collection of blood samples for point of care testing Reflects the time for Point of care testing
LabSampling.LSTissueCollctnDate Date of collection of blood samples for tissue Reflects the date for Tissue collection.
LabSampling.LSTissueCollctnTime Time of collection of blood samples for tissue Reflects the time for Tissue collection.
MedHx.AnticoagAntiThrombinProtein Anticoagulants: Antithrombin protein therapeutics (Atryn) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of antithrombin protein therapeutics (Atryn).
MedHx.AnticoagCoumarin Anticoagulants: Coumarin derivative (Coumadin, Warfarin) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of Coumarin derivative (Coumadin, Warfarin).
MedHx.AnticoagDirectThrombinInhib Anticoagulants: Direct thrombin inhibitor (eg. dabigatran, argatroban, melagatran) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of direct thrombin inhibitors (eg. dabigatran, argatroban, melagatran).
MedHx.AnticoagFactorXaInhib Anticoagulants: Inhibitor of factor Xa (eg. Rivaroxaban) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of inhibitor of factor Xa (eg. rivaroxaban).
MedHx.AnticoagHeparin Anticoagulants: Heparin Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of heparin.
MedHx.AnticoagLowMolHeparin Anticoagulants: Low-molecular weight heparin Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of low molecular weight heparin
MedHx.AnticoagulantOther Anticoagulants: Other Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of another type of anticoagulant or platelet aggregation inhibitor, not specified elsewhere.
MedHx.AnticoagulantOtherTxt Anticoagulants: Other (please specify) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of another type of anticoagulant or platelet aggregation inhibitor, not specified elsewhere. Text field.
MedHx.AnticoagulantReasonCardiac Were cardiac problems a reason for taking anticoagulant medication or platelet aggregation inhibitors? 0 == No
1 == Yes
Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiac.
MedHx.AnticoagulantReasonCardiacCABG Cardiac: CABG Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiac, specifically CABG.
MedHx.AnticoagulantReasonCardiacFibrill Cardiac: Atrial Fibrillation/Flutter Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiac, specifically atrial fibrillation/flutter.
MedHx.AnticoagulantReasonCardiacStent Cardiac: Cardiac stent Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiac, specifically a cardiac stent.
MedHx.AnticoagulantReasonCardiacValve Cardiac: Valve prosthesis Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiac, specifically a valve prosthesis.
MedHx.AnticoagulantReasonCardiovas Were cadiovascular problems a reason for taking anticoagulant medication or platelet aggregation inhibitors? 0 == N0
1 == Yes
Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiovascular.
MedHx.AnticoagulantReasonCardiovasCarotidStent Cardiovascular: Carotid or cerebral stent Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiovascular, specifically a carotid or cerebral stent.
MedHx.AnticoagulantReasonCardiovasLimbIsch Cardiovascular: Limb ischaemia Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiovascular, specifically limb ischaemia.
MedHx.AnticoagulantReasonCardiovasOtherStent Cardiovascular: Other stent Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiovascular, specifically a stent not specified elsewhere.
MedHx.AnticoagulantReasonCardiovasStenosis Cardiovascular: Cardiovascular stenosis Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiovascular, specifically a cardiovascular stenosis
MedHx.AnticoagulantReasonCardiovasTIS Cardiovascular: Transient Ischaemic Attack (TIA)/stroke Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is cardiovascular, specifically a transient ischaemic attack/stroke
MedHx.AnticoagulantReasonOther Other reason for taking anticoagulant medication or platelet aggregation inhibitors Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is not specified elsewhere.
MedHx.AnticoagulantReasonOtherTxt Other reason for taking anticoagulant medication or platelet aggregation inhibitors (please specify) Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is not specified elsewhere (text field).
MedHx.AnticoagulantReasonThrombo Was Thromboembolism a reason for taking anticoagulant medication or platelet aggregation inhibitors 0 == No
1 == Yes
Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is thromboembolic.
MedHx.AnticoagulantReasonThromboDVTLess6 Thromboembolism: Single episode of DVT or PE < 6 months Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is thromboembolic, specifically a single episode of DVT (deep venous thrombosis) or PE (pulmonary embolism) <6 months.
MedHx.AnticoagulantReasonThromboDVTMore6 Thromboembolism: Single episode of DVT or PE > 6 months Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is thromboembolic, specifically a single episode of DVT (deep venous thrombosis) or PE (pulmonary embolism) >6 months.
MedHx.AnticoagulantReasonThromboMultipleEpisode Thromboembolism: Two or more episodes of DVT or PE Medical history. This variable is populated when the reason for using anticoagulants or platelet aggregation inhibitors by the patient is thromboembolic, specifically two or more episodes of DVT (deep venous thrombosis) or PE (pulmonary embolism).
MedHx.AnticoagXarelto Anticoagulants: Xarelto Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of Xarelto
MedHx.BetaBlocker Does patient take blockers? 0 == No
1 == Yes
88 == Unknown
A specific question on the use of beta-blockers is included as some reports indicate better outcome with the use of beta blockers (Research interest Rotterdam). If yes, specification is requested and differentiated into: Non-selective blockers/Selective beta-1 blockers/alpha-1 and beta blockers.
MedHx.BetaBlockerAlphaBucundolol Alpha-1 and beta blockers: Bucundolol Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of a beta blocker, specifically Bucindolol.
MedHx.BetaBlockerAlphaCarvedilol Alpha-1 and beta blockers:Carvedilol (Eucardic) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of a beta blocker, specifically Carvedilol (Eucardic).
MedHx.BetaBlockerAlphaLabetolol Alpha-1 and beta blockers: Labetolol (Trandate) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of a beta blocker, specifically Labetalol (Trandate).
MedHx.BetaBlockerAlphaOther Alpha-1 and beta blockers: Other Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of an alpha 1 and beta-blocker, not specified elsewhere.
MedHx.BetaBlockerAlphaOtherTxt Alpha-1 and beta blockers: Other (please specify) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of an alpha 1 and beta-blocker, not specified elsewhere (text field).
MedHx.BetaBlockerNonSelectCarteolol Carteolol as Non-selective blockers Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of beta blockers, specifically Carteolol.
MedHx.BetaBlockerNonSelectNadolol Nadolol as Non-selective blockers Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of beta blockers, specifically Nadolol
MedHx.BetaBlockerNonSelectOther Other non-selective blockers (please specify) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of beta blockers, nonselective, not specified elsewhere.
MedHx.BetaBlockerNonSelectOtherTxt Other non-selective blockers (please specify) Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of beta blockers, nonselective, not specified elsewhere (textfield).
MedHx.BetaBlockerNonSelectPenbutolol Penbutolol as Non-selective blockers Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of beta blockers, specifically Penbutolo.
MedHx.BetaBlockerNonSelectPindolol Pindolol as Non-selective blockers Medical history. Use of anticoagulant or platelet aggregation inhibitor by the patient. This variable describes the use of beta blockers, specifically Pindolol (Viskeen)
MedHx.BetaBlockerNonSelectPropranolol Propranol as Non-selective blockers Medical history. This variable describes the use of beta blockers, specifically Propranolol
MedHx.BetaBlockerNonSelectSotalol Sotacor (Sotalol) as non-selective blockers Medical history. This variable describes the use of beta blockers, specifically Sotalol (Sotacor)
MedHx.BetaBlockerSelectAcebutolol Acebutolol (Sectral) as Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically Acebutolol (Sectral)
MedHx.BetaBlockerSelectAtenolol Atenolol (Tenormin) as Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically Atenolol (Tenormin)
MedHx.BetaBlockerSelectBetaxolol Betaxolol (Kerlon) as Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically Betaxolol (Kerlon)
MedHx.BetaBlockerSelectBisoprolol Bisoprolol (Emcor) as Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically Bisoprolol (Emcor)
MedHx.BetaBlockerSelectCeliprolol Celiprolol (Dilanorm) as Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically Celiprolol (Dilanorm)
MedHx.BetaBlockerSelectEsmolol Esmolol (Brevibloc) as Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically Esmolol (Brevibloc)
MedHx.BetaBlockerSelectMetoprolol Metoprolol (Selokeen) as Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically Metoprolol (Selokeen).
MedHx.BetaBlockerSelectNebivolol Nebivolol (Nebilet) as Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically Nebivolol (Nebilet)
MedHx.BetaBlockerSelectOther Other Selective beta1-blockers Medical history. This variable describes the use of beta blockers, specifically selective beta1blockers not specified elsewhere.
MedHx.BetaBlockerSelectOtherTxt Other Selective beta1-blockers (please specify) Medical history. This variable describes the use of beta blockers, specifically selective beta1blockers not specified elsewhere (text field).
MedHx.MedHxAnticoagulantsOrPlatelet Does patient take either anticoagulants or platelet aggregation inhibitors? 88 == Unknown
1 == Yes anticoagulants
0 == No
2 == Yes platelet aggregation inhibitors
3 == Yes, both
Summary question to document if the subject was taking anticoagulants or platelet aggregation inhibitors prior to injury. If yes, details are requested concerning which (groups of) agents were used. This information is of high relevance in relation to the shift of epidemiologic patterns in TBI towards higher age (with more co-morbidities and medication).
MedHx.MedHxCardio 010 Cardiovascular 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history.
MedHx.MedHxCardioArrhythmia 012 Cardiovascular: Arrhythmia Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, specifically arrhythmia.
MedHx.MedHxCardioCongenitalHD 011 Cardiovascular: Congenital heart disease Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, specifically congenital heart disease.
MedHx.MedHxCardioHTN 015 Cardiovascular: Hypertension Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, specifically hypertension
MedHx.MedHxCardioIschemicHD 013 Cardiovascular: Ischemic heart disease Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, specifically Ischemic heart disease
MedHx.MedHxCardioNYHA Cardiovascular: NYHA classification I == I
II == II
III == III
IV == IV
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, specifically NYHA, a classification system for severity of cardiac disease - generally used for ischaemia, but used here in broader sense.
MedHx.MedHxCardioOther 018 Cardiovascular: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, not specified elsewhere.
MedHx.MedHxCardioOtherTxt Cardiovascular: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, not specified elsewhere (textfield)
MedHx.MedHxCardioPeripheralVascular 017 Cardiovascular: Peripheral vascular disease Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, specifically peripheral vascular disease.
MedHx.MedHxCardioThromboembolic 016 Cardiovascular: Thromboembolic Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, specifically thromboembolic
MedHx.MedHxCardioValvularHD 014 Cardiovascular: Valvular heart disease Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting cardiovascular medical history, specifically valvular heart disease
MedHx.MedHxDevelopmental 150 Developmental 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting developmental diseases.
MedHx.MedHxDevelopmentalADDandADHD 152 Developmental: Attention deficit/hyperactivity disorder Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting developmental diseases, specifically attention deficit/hyperactivity disorder.
MedHx.MedHxDevelopmentalLearningDisability 151 Developmental: Learning disability Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting developmental diseases, specifically learning disability
MedHx.MedHxDevelopmentalOther 153 Developmental: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting developmental diseases that are not specified elsewhere.
MedHx.MedHxDevelopmentalOtherTxt Developmental: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting developmental diseases that are not specified elsewhere (textfield).
MedHx.MedHxEndocrine 020 Endocrine 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting endocrine diseases
MedHx.MedHxEndocrineIDDM 022 IDDM (Endocrine: Insulin Dependent Diabetes Mellitus) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting endocrine diseases, specifically IDDM (Insulin dependent diabetes mellitus)
MedHx.MedHxEndocrineIDDMControl Endocrine: How well is IDDM controlled? 1 == Well controlled
2 == Difficult controlled
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting for endocrine diseases, specifically IDDM (Insulin dependent diabetes mellitus) - how well it is controlled.
MedHx.MedHxEndocrineNIDDM 023 NDDM (Endocrine: Non-insulin Dependent Diabetes Mellitus) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting endocrine diseases, specifically NIDDM (Non-insulin dependent diabetes mellitus)
MedHx.MedHxEndocrineNIDDMControl Endocrine: How well is NIDDM controlled? 1 == Well controlled
2 == Difficult controlled
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting for endocrine diseases, specifically NIDDM (Non-insulin dependent diabetes mellitus), how well it is controlled.
MedHx.MedHxEndocrineOther 024 Endocrine: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting endocrine diseases not mentioned elsewhere.
MedHx.MedHxEndocrineOtherTxt Endocrine: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting endocrine diseases not specified elsewhere (textfield).
MedHx.MedHxEndocrineThyroid 021 Endocrine: Thyroid Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting endocrine diseases, specifically thyroid disorder.
MedHx.MedHxENT 030 ENT (Eye, Ear, Nose and Throat) 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting ENT (Eye, Ear, Nose & Throat) disease
MedHx.MedHxENTHearing 033 ENT (Eye, Ear, Nose and Throat): Hearing Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting ENT (Eye, Ear, Nose & Throat) disease, specifically hearing deficits.
MedHx.MedHxENTOther 034 ENT (Eye, Ear, Nose and Throat): Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting ENT (Eye, Ear, Nose & Throat) diseases not specified elsewhere.
MedHx.MedHxENTOtherTxt ENT (Eye, Ear, Nose and Throat): Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting ENT (Eye, Ear, Nose & Throat) diseases not specified elsewhere (textfield).
MedHx.MedHxENTSinusitis 031 ENT (Eye, Ear, Nose and Throat): Sinusitis Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting ENT (Eye, Ear, Nose & Throat) diseases, specifically sinusitis.
MedHx.MedHxENTVisionAbn 032 ENT (Eye, Ear, Nose and Throat): Vision abnormality Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting ENT (Eye, Ear, Nose & Throat) diseases, specifically vision.
MedHx.MedHxGastro 040 Gastrointestinal 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting gastrointestinal disease.
MedHx.MedHxGastroGERD 041 Gastrointestinal: GERD (Gastroesophageal Reflux Disease) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting gastrointestinal disease, specifically GERD (Gastroesophageal Reflux Disease).
MedHx.MedHxGastroGIBleed 042 Gastrointestinal: GI bleed Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting gastrointestinal disease, specifically gastrointestinal bleeding.
MedHx.MedHxGastroIBS 043 Gastrointestinal: Inflammatory bowel disease Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting gastrointestinal disease, specifically inflammatory bowel disease.
MedHx.MedHxGastroOther 044 Gastrointestinal: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting gastrointestinal disease not specified elsewhere.
MedHx.MedHxGastroOtherTxt Gastrointestinal: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting gastrointestinal disease not specified elsewhere (textfield).
MedHx.MedHxHematologic 050 Hematologic 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hematologic diseases.
MedHx.MedHxHematologicAIDS 053 Hematologic: AIDS Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hematologic diseases, specifically AIDS
MedHx.MedHxHematologicAnemia 051 Hematologic: Anemia Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hematologic diseases, like anemia.
MedHx.MedHxHematologicHIV 052 Hematologic: HIV positive Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hematologic diseases, like HIV positive.
MedHx.MedHxHematologicOther 055 Hematologic: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hematologic diseases, not specified elsewhere.
MedHx.MedHxHematologicOtherTxt Hematologic: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hematologic diseases, not specified elsewhere (textfield).
MedHx.MedHxHematologicSickleCell 054 Hematologic: Sickle cell disease Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hematologic diseases, specifically sickle cell disease.
MedHx.MedHxHepatic 060 Hepatic 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hepatic diseases.
MedHx.MedHxHepaticCirrhosis 064 Hepatic: Cirrhosis Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hepatic diseases, specifically cirrhosis.
MedHx.MedHxHepaticFailure 062 Hepatic: Failure Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hepatic diseases, specifically hepatic failure
MedHx.MedHxHepaticHepatitis 063 Hepatic: Hepatitis Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hepatic diseases, specifically hepatitis.
MedHx.MedHxHepaticInsufficiency 061 Hepatic: Insufficiency Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hepatic diseases, specifically hepatic insufficiency.
MedHx.MedHxHepaticOther 065 Hepatic: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hepatic diseases not specified elsewhere
MedHx.MedHxHepaticOtherTxt Hepatic: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting hepatic diseases not specified elsewhere (textfield)
MedHx.MedHxMusculoskeletal 070 Musculoskeletal 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting musculoskeletal diseases
MedHx.MedHxMusculoskeletalArthritis 071 Musculoskeletal: Arthritis Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting musculoskeletal diseases, specifically arthritis
MedHx.MedHxMusculoskeletalOther 072 Musculoskeletal: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting musculoskeletal diseases not specified elsewhere.
MedHx.MedHxMusculoskeletalOtherTxt Musculoskeletal: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting musculoskeletal diseases not specified elsewhere (textfield)
MedHx.MedHxNeuro 080 Neurologic 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases.
MedHx.MedHxNeuroCerebrovascularAccident 081 Neurologic: Cerebrovascular accident Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically cerebrovascular accidents.
MedHx.MedHxNeuroEpilepsyGeneralized 085 Neurologic: Epilepsy (generalized) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically epilepsy (generalized).
MedHx.MedHxNeuroEpilepsyOther 086 Neurologic: Epilepsy (other) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically epilepsy (other).
MedHx.MedHxNeuroEpilepsyPartial 084 Neurologic: Epilepsy (partial) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically epilepsy (partial).
MedHx.MedHxNeuroFebrileSeizures 083 Neurologic: Febrile seizures (children) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically febrile seizures (children).
MedHx.MedHxNeuroHeadache 091 Neurological (Aches): Headache - non migraine Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically headache (non migraine).
MedHx.MedHxNeuroMigraine 092 Neurological (Aches): Headache - migraines Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically migraines.
MedHx.MedHxNeuroMigraineFamHist 093 Neurological (Aches): Family history of migraine Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically family history of migraine.
MedHx.MedHxNeuroOther 086 Neurologic: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases not specified elsewhere.
MedHx.MedHxNeuroOtherTxt Neurologic: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases not specified elsewhere (textfield)
MedHx.MedHxNeuroPain 090 Neurological (Aches) 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases not specified elsewhere (textfield)
MedHx.MedHxNeuroTIA 082 Neurologic: Transient ischemic attacks (TIA) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting neurological diseases, specifically transient ischemic attacks
MedHx.MedHxOncologic 110 Oncologic 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases.
MedHx.MedHxOncologicBreast 113 Oncologic: Breast cancer Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases, like breast cancer.
MedHx.MedHxOncologicGI 116 Oncologic: GI cancer Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases, specifically gastrointestinal cancer.
MedHx.MedHxOncologicKidney 117 Oncologic: Kidney cancer Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases, specifically kidney cancer.
MedHx.MedHxOncologicLeukemia 111 Oncologic: Leukemia Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases, specifically leukemia.
MedHx.MedHxOncologicLung 115 Oncologic: Lung cancer Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases, specifically lung cancer.
MedHx.MedHxOncologicLymphoma 112 Oncologic: Lymphoma Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases, specifically lymphoma.
MedHx.MedHxOncologicOther 118 Oncologic: Other cancer Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases not specified elsewhere
MedHx.MedHxOncologicOtherTxt Oncologic: Other cancer (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic diseases not specified elsewhere (textfield).
MedHx.MedHxOncologicProstate 114 Oncologic: Prostrate cancer Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting oncologic, specifically prostate cancer.
MedHx.MedHxOther 160 Other medical history 0 == No
1 == Yes
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting other medical history, not specified elsewhere.
MedHx.MedHxOtherTxt Other medical history (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting other medical history, not specified elsewhere (textfield)
MedHx.MedHxPreInjASAPSClass Pre-injury ASA-PS Classification system 88 == Unknown
1 == A normal healthy patient
2 == A patient with mild systemic disease
3 == A patient with severe systemic disease
4 == A patient with a severe systemic disease that is a constant threat to life
Preinjury ASAPS classification. Common classification system used in anaesthesia; denotes overall health
MedHx.MedHxPreTBIConcussions 100 Previous TBI or concussions 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting previous TBI/ concussions
MedHx.MedHxPreTBIConcussionsTotal Total number of TBI or concussions Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting total number of previous TBI/ concussions
MedHx.MedHxPreTBIConcussionsTotalHosAdmit Number of hospital admissions for TBI or concussions Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting total number of hospital admissions for previous TBI/ concussions
MedHx.MedHxPsychiatric 130 Psychiatric 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting psychiatric diseases.
MedHx.MedHxPsychiatricAnx 131 Psychiatric: Anxiety Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting psychiatric diseases, specifically anxiety.
MedHx.MedHxPsychiatricDep 132 Psychiatric: Depression Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting psychiatric diseases, specifically depression.
MedHx.MedHxPsychiatricOther 135 Psychiatric: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting psychiatric diseases not documented elsewhere.
MedHx.MedHxPsychiatricOtherTxt Psychiatric: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting psychiatric diseases not documented elsewhere (textfield).
MedHx.MedHxPsychiatricSchiz 134 Psychiatric: Schizophrenia Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting psychiatric diseases, specifically schizophrenia.
MedHx.MedHxPsychiatricSleep 133 Psychiatric: Sleep disorders Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting psychiatric diseases, specifically sleep disorders.
MedHx.MedHxPsychiatricSubstanceAbuse 135 Psychiatric: Substance abuse disorder Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting psychiatric diseases, specifically substance abuse disorders.
MedHx.MedHxPulmonary 120 Pulmonary 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting pulmonary diseases
MedHx.MedHxPulmonaryAsthma 122 Pulmonary: Asthma Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting pulmonary diseases, specifically asthma.
MedHx.MedHxPulmonaryCOPD 121 Pulmonary: COPD Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting pulmonary diseases, specifically COPD (Chronic Obstructive Pulmonary Disease)
MedHx.MedHxPulmonaryOther 125 Pulmonary: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting pulmonary diseases not specified elsewhere.
MedHx.MedHxPulmonaryOtherTxt Pulmonary: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting pulmonary diseases not specified elsewhere (textfield).
MedHx.MedHxPulmonaryPneumonia 123 Pulmonary: Pneumonia Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting pulmonary diseases, specifically pneumonia.
MedHx.MedHxPulmonaryTB 124 Pulmonary: Tuberculosis Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting pulmonary diseases, specifically tuberculosis.
MedHx.MedHxRenal 140 Renal 0 == No
1 == Yes
88 == Unknown
Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting renal diseases.
MedHx.MedHxRenalFailure 143 Renal: Failure Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting renal diseases, specifically renal failure.
MedHx.MedHxRenalInsufficiency 141 Renal: Insufficiency Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting renal diseases, specifically renal insufficiency.
MedHx.MedHxRenalOther 144 Renal: Other Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting renal diseases not specified elsewhere.
MedHx.MedHxRenalOtherTxt Renal: Other (please specify) Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting renal diseases not specified elsewhere (textfield).
MedHx.MedHxRenalUTI 143 Renal: UTI Details on Medical History are captured for 15 body regions/disease area's. If overall question for the body region/disease is "yes", more detailed info is requested and captured in the sub-domains. This variable is used for documenting renal diseases, specifically chronic UTI (urinary tract infection).
MedHx.PlateletAggreOther Platelet aggregation inhibitors: Other Medical history. Variable documents the use of anticoagulants or platelet aggregation inhibitors. This variable contains the medication of this type not specified elsewhere.
MedHx.PlateletAggreOtherTxt Platelet aggregation inhibitors: Other (please specify) Medical history. Variable documents the use of anticoagulants or platelet aggregation inhibitors. This variable contains the medication of this type not specified elsewhere (textfield).
MedHx.PltAggregAdenosineInhib Platelet aggregation inhibitors: Adenosine re-uptake inhibitor (eg. Persantin, Dipyridamole) Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of an adenosine reuptake inhibitor (eg. Persantin, dipyridamole).
MedHx.PltAggregADPReceptInhib Platelet aggregation inhibitors: ADP receptor inhibitors Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of ADP receptor inhibitors.
MedHx.PltAggregADPReceptInhibEffient Platelet aggregation inhibitors: Parasugrel (Effient) Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of Parasugrel (Effient)
MedHx.PltAggregADPReceptInhibOther Platelet aggregation inhibitors: Other ADP receptor inhibitors Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of ADP receptor inhibitors, not specified elsewhere.
MedHx.PltAggregADPReceptInhibOtherTxt Platelet aggregation inhibitors: Other ADP receptor inhibitors (please specify) Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of ADP receptor inhibitors, not specified elsewhere (textfield).
MedHx.PltAggregADPReceptInhibPlavix Platelet aggregation inhibitors: Clopidogrel (Plavix) Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of Clopidogrel (Plavix).
MedHx.PltAggregADPReceptInhibTiclid Platelet aggregation inhibitors: Ticlopidine (Ticlid) Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of Ticlopidine (Ticlid).
MedHx.PltAggregAspirin Platelet aggregation inhibitors: Aspirin Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of Aspirin
MedHx.PltAggregGlycoproteinInhib Platelet aggregation inhibitors: Glycoprotein IIB/IIIA inhibitors (eg. Aggrastat) Medical history. Use of platelet aggregation inhibitor by the patient. This variable describes the use of glycoprotein IIB/IIIA inhibitors (eg. Aggrastat).
Medication.Agent Agent 99 == Other, specify in Agent Other: Other
66 == Prokinetics: Metoclopramide (Primperan)
64 == Prokinetics: Domperidon (Motilium)
65 == Prokinetics: Erythromycin
63 == Proton pump inhibitors: Pantoprazole (Pantozol)
62 == Proton pump inhibitors: Esomeprazol (Nexium)
61 == Proton pump inhibitors: Omeprazol (Losec)
60 == H2 receptor antagonist: Ranitidine (Zantac)
59 == H2 receptor antagonist: Cimetidine
58 == Antacids: other
57 == Antacids: Aluminium hydroxide
56 == Steroids: hydrocortisone/cortisone
55 == Steroids: dexametasone
54 == Steroids: bétametasone
53 == Steroids: methylprednisolone
52 == Calcium channel blockers: verapamil
51 == Calcium channel blockers: nicardipine
50 == Calcium channel blockers: nimodipine
49 == Anti- hypertensive: diuretics
48 == Anti- hypertensive: clonidine
47 == Anti- hypertensive: bètablockers (propanolol)
46 == Anti- hypertensive: angiotensininhibitors (cardesartan etc)
45 == Anti- hypertensive: ACE blockers (captopril, perindopril etc)
44 == Antibiotics: other
43 == Antibiotics: sulfonamides (co-trimoxazole, doxycycline)
42 == Antibiotics: quinolones (ciprofloxacine etc)
41 == Antibiotics: amoxycilline/clavulanic acid (augmentin, tyclav etc)
40 == Antibiotics: penicillines (ampicilline, cloxacilline)
39 == Antibiotics: nitrofurones (furoxone, furadantine etc)
38 == Antibiotics: macrolidis (erythromycine etc)
37 == Antibiotics: lincosamides (clindamycine etc)
36 == Antibiotics: glycopeptides (vancomycine)
35 == Antibiotics: cephalosporin 5th gen (ceftasoline etc)
34 == Antibiotics: cephalosporin 4th gen (cefepime, maxipime etc)
33 == Antibiotics: cephalosporin 3rd gen (cefotaxine etc)
32 == Antibiotics: cephalosporin 2nd gen (cefuroxim etc)
31 == Antibiotics: cephalosporin 1st gen (cefalexin etc)
30 == Antibiotics: carbapemens (meronem etc)
29 == Antibiotics: aminoglycoside (amikacine, gentamicine etc)
28 == Anti- epileptic: other
27 == Anti- epileptic: valproate (depakine)
26 == Anti- epileptic: phenytoine (diphantoine)
25 == Anti- epileptic: levetirazetam (keppra)
24 == Anti- epileptic: lamotrigine (lamectal)
23 == Anti- epileptic: carbamazepine (tegretol)
22 == Neuromuscular blockade: other
21 == Neuromuscular blockade: vecuronium (norcuron)
20 == Neuromuscular blockade: rocuronium (zemuron)
19 == Neuromuscular blockad: gallamine (flaxedil)
18 == Neuromuscular blockade: cisatracurium (nimbex)
17 == Neuromuscular blockade: atracurium (tracium)
16 == Neuromuscular blockade: pancuronium (pavulon)
15 == Sedatives/treatment of agitation: other
14 == Sedatives/treatment of agitation: propofol
13 == Sedatives/treatment of agitation: morphine
12 == Sedatives/treatment of agitation: midazolam
11 == Sedatives/treatment of agitation: lorazepam (tenesta, ect)
10 == Sedatives/treatment of agitation: haloperidol (haldol)
9 == Sedatives/treatment of agitation: fentanyl
8 == Sedatives/treatment of agitation: diazepam
7 == Sedatives/treatment of agitation: dexmedetomidine
6 == Sedatives/treatment of agitation: clondine
5 == Sedatives/treatment of agitation: barbiturates (penthothal, ect)
4 == Analgesic: opioids (morphine, ect)
3 == Analgesic: tramadol
2 == Analgesic: NSAIDs
1 == Analgesic: paracetamol
67 == Analgesic: other
68 == Anti- hypertensive: other
69 == Calcium channel blockers: other
70 == Steroids: other
71 == H2 receptor antagonist: other
72 == Proton pump inhibitors: other
73 == Prokinetics:other
Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes the Agent. Agents commonly used for treatment of raised ICP are listed in the TIL section, but not included in the medication lists here.
Medication.AgentOther Other agent (please specify) Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes if the Agent was "other" than the predefined list.
Medication.Class Class 99 == Other, specify in Agent Other
1 == Analgesic
6 == Anti- hypertensive
5 == Antibiotics
4 == Anti- epileptic
3 == Neuromuscular blockade
2 == Sedatives/treatment of agitation
11 == Proton pump inhibitors
12 == Prokinetics
10 == H2 receptor antagonist
8 == Steroids
9 == Antacids
7 == Calcium channel blockers
Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes the Classes. Classes: analgesic, sedatives, neuromuscular blocking agents, anti-epileptic drugs, antibiotiucs, anti-hypertensive, calcium channel blockers, steroids, antacids, H2 receptor antagonists, proton pump inhibitors and prokinetics. Agents commonly used for treatment of raised ICP are listed in the TIL section, but not included in the medication lists here.
Medication.HighestDailyDose Highest daily dose Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes the Highest Daily Dose. These details should be entered for each agent.
Medication.Ongoing Is medication ongoing? Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes if medication was still ongoing on discharge. These details should be entered for each agent.
Medication.Reason Reason for taking medication 99 == Other, specify in Agent Other: Other
46 == Prokinetics: Other
45 == Proton pump inhibitors: Other
44 == H2 receptor antagonist: Other
43 == Antacids: Other
42 == Steroids: Other
41 == Calcium channel blockers: Other
40 == Anti- hypertensive: Other
39 == Antibiotics: Other
37 == Sedatives/treatment of agitation: Other
38 == Anti- epileptic: Other
36 == Neuromuscular blockade: other
35 == Analgesic: other
33 == Prokinetics: routine care
32 == Prokinetics: constipation
31 == Prokinetics: vomiting
30 == Prokinetics: gastric retention
29 == Proton pump inhibitors: treatment of ulcer
28 == Proton pump inhibitors: gastric protection
27 == H2 receptor antagonist: treatment of ulcer
26 == H2 receptor antagonist: gastric protection
25 == Antacids: reflux
24 == Antacids: gastric protection
23 == Steroids: sepsis
22 == Steroids: hypopituitarism
21 == Steroids: ARDS
20 == Steroids: traumatic brain injury
19 == Calcium channel blockers: cardiac indication
17 == Calcium channel blockers: treatment of vasospasm
18 == Calcium channel blockers: anti- hypertensive
16 == Calcium channel blockers: prevention of vasospasm
15 == Anti- hypertensive: treatment agitation
14 == Anti- hypertensive: to lower blood pressure
12 == Antibiotics: periprocedural prophylaxis
13 == Antibiotics: meningitis
11 == Antibiotics: intracranial abces/empyeme
10 == Antibiotics: catheter related bloodstream infection
9 == Antibiotics: urinary tract infection
7 == Antibiotics: fever, no clear focus
8 == Antibiotics: pneumonia
6 == Anti- epileptic: treatment of (silent) seizure activity
4 == Anti- epileptic: treatment of overt seizure
3 == Anti- epileptic: prophylaxis
2 == Sedatives/treatment of agitation: metabolic suppression
1 == Sedatives/treatment of agitation: mechanical ventilation
Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes the Reason for medication. These details should be entered for each agent.
Medication.ReasonOther Other reason for taking medication (please specify) Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes the Reason for medication if this was "other than the predefined ones. These details should be entered for each agent.
Medication.Route Route Sc == Subcutaneous
To == Topical
Pv == Vaginal
PO == Oral
Im == Intramuscular
Re == Rectal
Ih == Inhaled
IvInt == Intermittent IV
IvCont == Continuous IV
ED == Epidural
Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes the Route. These details should be entered for each agent.
Medication.StartDate Date medication was started Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes the Start date for medication. These details should be entered for each agent.
Medication.StopDate Date medication was stopped Details on medication captured information on Class, Agent, Reason, Highest daily dose, Route, start and stop date and whether or not medication has been ongoing after discharge. This variable describes the Stop date for medication. These details should be entered for each agent.
Meds.DVTMechOngoing Is mechanical treatment ongoing? These variables aim to document specific information on the use of DVT prophylaxis. Little evidence exists on the use and timing of DVT prophylaxis after TBI, and considerable practice variation exists. This variable describes if Mechanical DVT was still ongoing after discharge.
Meds.DVTPharmOngoing Is pharmacological treatment ongoing? These variables aim to document specific information on the use of