Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal
suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical,
medical, social and health economic reasons therefore exist for improving treatment.
The Center-TBI project collected a prospective, contempary, highly granular, observational dataset of
4,500 patients, which has been used for better characterization of TBI and for Comparative Effectiveness
The generalizability of our results were reinforced by a contemporaneous registry level data
collection over 22,000 patients. Our conceptual approach is to exploit the heterogeneity in biology,
care, and outcome of TBI, to discover novel pathophysiology, refine disease characterization, and
identify effective clinical interventions.
Key elements are the use of emerging technologies (biomarkers, genomics and advanced MR imaging) in
large numbers of patients, across the entire course of TBI (from injury to late outcome) and across all
severities of injury (mild to severe).
Improved characterization with these tools will aid Precision Medicine, a concept recently advocated by
the US National Academy of Science, facilitating targeted management for individual patients. Our
consortium includes leading experts and will bring outstanding biostatistical and neuroinformatics
expertise to the project.
Collaborations with external partners, other FP7 consortia, international links within InTBIR, have
greatly augment scientific resources and broaden the global scope of our research.
that the project could revolutionize our view of TBI, leading to more effective and efficient therapy,
thus improving outcome and reducing costs.
These outcomes reflect the goals of CER to assist consumers, clinicians, health care purchasers, and
policy makers to make informed decisions, and will improve healthcare at both individual and population