A total of 44 scientific institutes worldwide and more than 68 hospitals in Europe and Israel participated in the project.
The official launch of the project took place in Antwerp on the 11th and 12th of October 2013 and was attended by 80 top experts from Europe, China, America and Australia.

The project forms one pillar of an ongoing global International Traumatic Brain Injury Research initiative, which was also being supported by research funding in the USA, Canada, and other countries. The observational study which forms the basis of analysis for CENTER-TBI started in November 2014 and aimed to gather data on over 4,500 patients in Europe and Israel.

The total duration of CENTER-TBI including full analysis of all results was 7.5 years with an end date on 31 March 2021. The concept of CENTER-TBI was attracting worldwide attention and partner projects have been set up in Australia, China and India.
44 scientific institutes and more than 68 hospitals in Europe participated in the project.

The CENTER-TBI study has been listed in the registry of clinical trials.gov, a service maintained by the US National Institutes of Health (registration number: NCT02210221; https://clinicaltrials.gov) Extensive details of the study protocol have been accepted for publication in Neurosurgery, a major international neurosurgical journal.